SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 574
GLY A 396
ASP A 395
 None
 0.55A 1kf6A-3pstA:
2.2
1kf6B-3pstA:
undetectable		 1kf6A-3pstA:
21.38
1kf6B-3pstA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 438
PHE A 417
VAL A 391
 None
 0.79A 1kijA-3pstA:
undetectable		 1kijA-3pstA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 395
ARG A 541
LEU A 542
TYR A 427
ILE A 393
 None
 1.48A 1q6iB-3pstA:
undetectable		 1q6iB-3pstA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 541
SER A 630
TYR A 629
 None
 0.70A 1x70A-3pstA:
undetectable		 1x70A-3pstA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 469
ASP A 713
LEU A 714
GLY A 675
 None
 0.92A 3af0A-3pstA:
undetectable		 3af0A-3pstA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 392
ARG A 706
ARG A 669
 None
 0.86A 4x5iA-3pstA:
undetectable		 4x5iA-3pstA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 565
THR A 567
ILE A 532
GLU A 531
 None
 1.10A 5uigA-3pstA:
undetectable		 5uigA-3pstA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 697
PHE A 711
LEU A 677
ALA A 678
LEU A 467
 None
 1.26A 5y7pH-3pstA:
undetectable		 5y7pH-3pstA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 619
GLN A 616
LYS A 613
ASP A 395
 None
 1.29A 5y9aA-3pstA:
undetectable		 5y9aA-3pstA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3pst PROTEIN DOA1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 401
VAL A 388
ASP A 390
 None
 0.33A 6fgdA-3pstA:
undetectable		 6fgdA-3pstA:
22.68