SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 247
ALA A 231
LEU A 235
LEU A 266
ILE A 185
 None
 1.15A 1bsxA-3pt1A:
undetectable		 1bsxA-3pt1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 247
ALA A 231
LEU A 235
LEU A 266
ILE A 185
 None
 1.15A 1bsxB-3pt1A:
undetectable		 1bsxB-3pt1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 227
LEU A 390
SER A 416
SER A 466
 None
 1.18A 1ig3A-3pt1A:
undetectable
1ig3B-3pt1A:
undetectable		 1ig3A-3pt1A:
21.19
1ig3B-3pt1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 9 THR A 194
GLY A 191
GLY A 147
LEU A 199
SER A 144
 GOL  A1000 (-4.5A)
None
None
None
None
 1.26A 1jhoA-3pt1A:
undetectable		 1jhoA-3pt1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 9 THR A 194
GLY A 191
GLY A 147
LEU A 199
SER A 144
 GOL  A1000 (-4.5A)
None
None
None
None
 1.26A 1jhrA-3pt1A:
undetectable		 1jhrA-3pt1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 9 THR A 194
GLY A 191
GLY A 147
LEU A 199
SER A 144
 GOL  A1000 (-4.5A)
None
None
None
None
 1.24A 1l5kA-3pt1A:
undetectable		 1l5kA-3pt1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 9 THR A 194
GLY A 191
GLY A 147
LEU A 199
SER A 144
 GOL  A1000 (-4.5A)
None
None
None
None
 1.25A 1l5mA-3pt1A:
undetectable		 1l5mA-3pt1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 254
ASP A 263
LYS A 284
 F6P  A1001 ( 2.6A)
None
None
 1.17A 1lqtB-3pt1A:
2.1		 1lqtB-3pt1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		3 / 3 THR A 203
GLU A 156
ASP A 325
 None
 0.73A 1nt2A-3pt1A:
4.0		 1nt2A-3pt1A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 379
ASP A 345
TRP A 348
LEU A 390
 None
 1.20A 1pk2A-3pt1A:
undetectable		 1pk2A-3pt1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 379
ASP A 345
TRP A 348
LEU A 409
 None
 1.13A 1pk2A-3pt1A:
undetectable		 1pk2A-3pt1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  27
ILE A  28
ALA A  31
ILE A 286
PHE A  62
 None
 1.18A 1xzxX-3pt1A:
undetectable		 1xzxX-3pt1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 247
ALA A 231
LEU A 235
LEU A 266
ILE A 185
 None
 1.10A 2h79A-3pt1A:
undetectable		 2h79A-3pt1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 MET A 331
LEU A 305
LEU A 301
LEU A 253
VAL A 293
 None
 1.21A 2po7B-3pt1A:
undetectable		 2po7B-3pt1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 181
LEU A 162
SER A 376
ASN A 377
ALA A 276
 None
 1.48A 2vdmA-3pt1A:
undetectable
2vdmB-3pt1A:
undetectable		 2vdmA-3pt1A:
22.65
2vdmB-3pt1A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 298
VAL A 302
LEU A 159
ALA A 268
PHE A 334
 None
 1.33A 3apxA-3pt1A:
undetectable		 3apxA-3pt1A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 112
GLU A  79
LEU A 113
TRP A 101
 None
 1.40A 3k8mB-3pt1A:
undetectable		 3k8mB-3pt1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 312
SER A 321
LEU A 324
ASP A 325
 None
 1.12A 3lsfH-3pt1A:
undetectable		 3lsfH-3pt1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 264
ALA A 262
GLU A 259
LEU A 253
ILE A 340
 None
 1.26A 3olsB-3pt1A:
undetectable		 3olsB-3pt1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 181
LEU A 417
ALA A 276
LEU A 266
 None
 1.01A 3t3zD-3pt1A:
undetectable		 3t3zD-3pt1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 114
VAL A 117
PHE A 133
ILE A  66
 None
 0.92A 3zjqA-3pt1A:
undetectable		 3zjqA-3pt1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 114
VAL A 117
PHE A 133
ILE A  66
 None
 0.94A 3zjqB-3pt1A:
undetectable		 3zjqB-3pt1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 187
ASP A 263
LYS A 382
ILE A 380
LEU A 270
 None
 1.21A 4a81A-3pt1A:
undetectable		 4a81A-3pt1A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 146
THR A 200
GLU A 320
 None
 0.79A 4df3A-3pt1A:
3.6		 4df3A-3pt1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 146
THR A 200
GLU A 320
 None
 0.74A 4df3B-3pt1A:
3.3		 4df3B-3pt1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 ARG A  23
GLU A 110
GLY A  16
TYR A 114
VAL A 290
 F6P  A1001 (-3.2A)
F6P  A1001 (-2.7A)
None
None
None
 1.45A 4ffwB-3pt1A:
undetectable		 4ffwB-3pt1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 344
ASP A 285
ASP A 297
 None
 0.65A 4gc9A-3pt1A:
4.3		 4gc9A-3pt1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 9 THR A 194
GLY A 191
GLY A 147
LEU A 199
SER A 144
 GOL  A1000 (-4.5A)
None
None
None
None
 1.27A 4kqiA-3pt1A:
undetectable		 4kqiA-3pt1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 394
TRP A 396
ILE A   3
 None
 1.08A 4mwxA-3pt1A:
undetectable		 4mwxA-3pt1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 461
ARG A 420
LEU A 430
PHE A   7
 None
 1.10A 4o1zA-3pt1A:
undetectable		 4o1zA-3pt1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 408
LEU A 409
GLN A 374
 None
 0.60A 4pevB-3pt1A:
3.1		 4pevB-3pt1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 180
VAL A 179
GLU A 183
ARG A 216
 None
 0.85A 4ww7A-3pt1A:
undetectable		 4ww7A-3pt1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 425
THR A 399
THR A 400
ALA A 405
CYH A 422
 None
 1.16A 5dsgA-3pt1A:
undetectable		 5dsgA-3pt1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 373
ILE A 414
GLY A 413
ASN A 377
LEU A 378
 None
 1.24A 5nfjB-3pt1A:
2.1		 5nfjB-3pt1A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 373
ILE A 414
GLY A 413
ASN A 377
LEU A 378
 None
 1.20A 5nfjC-3pt1A:
1.9		 5nfjC-3pt1A:
17.77