SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pt3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5
(Homo
sapiens) 		5 / 12 ILE A2717
LEU A2788
ALA A2790
ILE A2791
ILE A2752
 None
 1.11A 3b2rA-3pt3A:
undetectable		 3b2rA-3pt3A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5
(Homo
sapiens) 		5 / 11 ILE A2717
LEU A2788
ALA A2790
ILE A2791
ILE A2752
 None
 1.14A 3b2rB-3pt3A:
undetectable		 3b2rB-3pt3A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5
(Homo
sapiens) 		4 / 6 ILE A2791
PHE A2714
THR A2694
TRP A2715
 None
 1.27A 5g08A-3pt3A:
undetectable		 5g08A-3pt3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5
(Homo
sapiens) 		4 / 7 ASN A2703
SER A2700
ILE A2754
LEU A2776
 None
 1.01A 5u4sA-3pt3A:
undetectable		 5u4sA-3pt3A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5
(Homo
sapiens) 		4 / 8 ASN A2703
SER A2700
ILE A2754
LEU A2776
 None
 0.99A 5u4sB-3pt3A:
undetectable		 5u4sB-3pt3A:
17.43