SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		4 / 6 LEU A 164
VAL A 175
ILE A 115
ARG A 120
 None
 1.01A 2hyyA-3pt5A:
undetectable		 2hyyA-3pt5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		4 / 7 ASP A  71
VAL A  72
ALA A 139
THR A  14
 None
 0.95A 2q6oA-3pt5A:
2.1		 2q6oA-3pt5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		4 / 6 HIS A  49
THR A  50
PHE A  47
GLN A  76
 None
 1.11A 3bgdA-3pt5A:
undetectable		 3bgdA-3pt5A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		5 / 7 GLN A 260
GLY A 266
GLU A 273
GLU A  26
ALA A 306
 None
 1.38A 3fpjB-3pt5A:
2.1		 3fpjB-3pt5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		3 / 3 LEU A 173
ARG A  40
ASN A 167
 None
 0.78A 3qxvD-3pt5A:
undetectable		 3qxvD-3pt5A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		4 / 6 GLU A  26
GLY A  27
GLY A 284
ASP A 274
 None
 0.95A 5a06D-3pt5A:
3.8		 5a06D-3pt5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		4 / 7 THR A 295
PHE A 182
GLN A  18
MET A 185
 None
 1.45A 5u6mA-3pt5A:
4.0		 5u6mA-3pt5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		4 / 5 TYR A 282
TYR A 283
GLY A 284
GLY A  27
 None
 1.15A 5x7pA-3pt5A:
1.5		 5x7pA-3pt5A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		4 / 5 ASP A 226
GLN A 247
GLN A 262
LYS A 232
 None
 1.18A 6g31H-3pt5A:
undetectable		 6g31H-3pt5A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE
(Escherichia
coli) 		4 / 6 ASP A 226
GLN A 247
GLN A 262
LYS A 232
 None
 1.26A 6g31L-3pt5A:
undetectable		 6g31L-3pt5A:
12.50