SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pt7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		5 / 10 HIS A  97
PHE A  44
MET A  31
GLY A  28
PHE A  29
 HEM  A 500 (-3.4A)
HEM  A 500 (-4.0A)
None
None
None
 1.17A 1uhoA-3pt7A:
undetectable		 1uhoA-3pt7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		4 / 5 LEU A 143
PHE A  69
MET A  73
SER A  75
 None
HEM  A 500 ( 4.8A)
HEM  A 500 (-3.7A)
None
 1.22A 1wrkB-3pt7A:
undetectable		 1wrkB-3pt7A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		5 / 12 LEU A 107
LEU A 143
ARG A 100
GLN A  65
LEU A  86
 HEM  A 500 (-4.8A)
None
HEM  A 500 (-2.9A)
HEM  A 500 ( 3.6A)
None
 1.38A 2qd4A-3pt7A:
undetectable		 2qd4A-3pt7A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		4 / 7 GLY A  72
ILE A 139
LEU A  86
PHE A 135
 HEM  A 500 ( 4.1A)
None
None
None
 0.85A 4ejjD-3pt7A:
undetectable		 4ejjD-3pt7A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		5 / 12 PHE A  29
TYR A  30
GLN A  65
LEU A 114
ILE A 139
 None
OXY  A 501 (-4.3A)
HEM  A 500 ( 3.6A)
None
None
 1.07A 4g1bA-3pt7A:
15.1		 4g1bA-3pt7A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		4 / 5 GLY A 137
ILE A  11
LYS A   8
GLN A   7
 None
 1.17A 4ma8C-3pt7A:
2.5		 4ma8C-3pt7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		5 / 10 ASP A 120
ALA A 110
ILE A 113
GLY A  28
PHE A  29
 None
HEM  A 500 ( 3.8A)
None
None
None
 1.12A 5i6xA-3pt7A:
undetectable		 5i6xA-3pt7A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		3 / 3 VAL A  77
SER A  75
TRP A  15
 None
 1.07A 5jwaA-3pt7A:
undetectable		 5jwaA-3pt7A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		4 / 5 LYS A  61
ALA A  64
LEU A  67
LEU A  47
 None
None
None
HEM  A 500 (-3.7A)
 0.87A 5vkqA-3pt7A:
2.0
5vkqD-3pt7A:
2.0		 5vkqA-3pt7A:
6.59
5vkqD-3pt7A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pt7 HEMOGLOBIN II
(Phacoides
pectinatus) 		4 / 5 LEU A  47
LYS A  61
ALA A  64
LEU A  67
 HEM  A 500 (-3.7A)
None
None
None
 0.88A 5vkqC-3pt7A:
2.0
5vkqD-3pt7A:
2.0		 5vkqC-3pt7A:
6.59
5vkqD-3pt7A:
6.59