SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 PRO A1375
HIS A1412
TRP A1519
GLU A1376
 None
 1.50A 1ffyA-3ptaA:
0.0		 1ffyA-3ptaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 8 PHE A1145
GLU A1168
ASP A1190
PRO A1225
LEU A1247
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.0A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
 0.55A 1hmyA-3ptaA:
26.1		 1hmyA-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 7 ALA A1166
PHE A1177
SER A1184
TRP A1165
 None
 1.27A 1lqtA-3ptaA:
3.6		 1lqtA-3ptaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 7 ALA A1166
PHE A1177
SER A1184
TRP A1165
 None
 1.26A 1lquA-3ptaA:
3.4		 1lquA-3ptaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASP A1190
CYH A1191
PRO A1225
PHE A1145
GLY A1147
 SAH  A1601 ( 4.7A)
SAH  A1601 (-3.3A)
SAH  A1601 (-4.2A)
SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
 0.46A 1nw5A-3ptaA:
4.4		 1nw5A-3ptaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 TRP A1498
ARG A1490
PHE A1492
 None
 1.15A 1zeaH-3ptaA:
undetectable
1zeaL-3ptaA:
undetectable		 1zeaH-3ptaA:
13.01
1zeaL-3ptaA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 PHE A1145
GLY A1147
GLY A1149
ASP A1190
PRO A1225
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 ( 4.8A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
 1.06A 2dpmA-3ptaA:
6.2		 2dpmA-3ptaA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 VAL A1298
PHE A1243
SER A1273
CYH A1226
VAL A1248
 None
 1.28A 2ft9A-3ptaA:
undetectable		 2ft9A-3ptaA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		6 / 12 PHE A1145
GLY A1147
GLY A1150
ASP A1190
LEU A1247
TYR A1563
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 (-3.6A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-3.7A)
None
 1.46A 2hmyB-3ptaA:
26.0		 2hmyB-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		7 / 12 PHE A1145
GLY A1147
GLY A1150
ASP A1190
PRO A1225
LEU A1247
VAL A1580
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 (-3.6A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
SAH  A1601 (-4.4A)
 0.90A 2hmyB-3ptaA:
26.0		 2hmyB-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 THR A 885
ASP A 741
SER A 745
 None
 0.78A 2nxeA-3ptaA:
2.4		 2nxeA-3ptaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 THR A 885
ASP A 741
SER A 745
 None
 0.79A 2nxeB-3ptaA:
1.4		 2nxeB-3ptaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ALA A1579
GLN A1557
LEU A1584
THR A1163
PHE A1177
 SAH  A1601 (-4.7A)
None
None
None
None
 1.44A 2oaxF-3ptaA:
undetectable		 2oaxF-3ptaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 LEU A1439
PRO A1440
LEU A1495
 None
 0.52A 2po7B-3ptaA:
2.2		 2po7B-3ptaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 11 LEU A1299
VAL A1306
GLN A1308
ILE A1588
LEU A1151
 None
None
None
None
SAH  A1601 (-3.6A)
 1.13A 2q6hA-3ptaA:
undetectable		 2q6hA-3ptaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 11 LEU A1299
VAL A1306
GLN A1308
ILE A1588
LEU A1151
 None
None
None
None
SAH  A1601 (-3.6A)
 1.13A 2q72A-3ptaA:
undetectable		 2q72A-3ptaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 LEU A1299
VAL A1306
GLN A1308
ILE A1588
LEU A1151
 None
None
None
None
SAH  A1601 (-3.6A)
 1.12A 2qb4A-3ptaA:
undetectable		 2qb4A-3ptaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 11 LEU A1299
VAL A1306
GLN A1308
ILE A1588
LEU A1151
 None
None
None
None
SAH  A1601 (-3.6A)
 1.11A 2qeiA-3ptaA:
undetectable		 2qeiA-3ptaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 ASP A 937
TYR A 940
TYR A 933
LEU A 941
 None
 1.19A 2w98A-3ptaA:
5.6
2w98B-3ptaA:
5.6		 2w98A-3ptaA:
16.27
2w98B-3ptaA:
16.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		12 / 12 PHE A1145
GLY A1147
GLY A1150
LEU A1151
MET A1169
TRP A1170
CYH A1191
PRO A1225
LEU A1247
ASN A1578
ALA A1579
VAL A1580
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 (-3.6A)
SAH  A1601 (-3.6A)
SAH  A1601 (-4.6A)
SAH  A1601 (-4.9A)
SAH  A1601 (-3.3A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-4.7A)
SAH  A1601 (-4.4A)
 0.54A 3av6A-3ptaA:
37.4		 3av6A-3ptaA:
64.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		6 / 12 PHE A1145
GLY A1149
PRO A1225
LEU A1247
ASN A1578
ALA A1579
 SAH  A1601 (-4.4A)
SAH  A1601 ( 4.8A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-4.7A)
 0.99A 3av6A-3ptaA:
37.4		 3av6A-3ptaA:
64.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 CYH A 820
CYH A 893
HIS A 795
 ZN  A   3 (-2.3A)
ZN  A   3 (-2.4A)
None
 0.88A 3dtuB-3ptaA:
undetectable		 3dtuB-3ptaA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 PHE A1145
ASP A1190
PRO A1225
LEU A1247
ASN A1578
 SAH  A1601 (-4.4A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
SAH  A1601 (-4.2A)
 0.65A 3eeoA-3ptaA:
22.0		 3eeoA-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 PHE A1145
GLY A1149
PRO A1225
LEU A1247
ASN A1578
 SAH  A1601 (-4.4A)
SAH  A1601 ( 4.8A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
SAH  A1601 (-4.2A)
 1.04A 3eeoA-3ptaA:
22.0		 3eeoA-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 PHE A1145
GLY A1150
ASP A1190
PRO A1225
LEU A1247
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.6A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
 0.57A 3eeoA-3ptaA:
22.0		 3eeoA-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ARG A1337
GLU A 704
ASP A 700
 None
 0.71A 3g2oA-3ptaA:
8.3		 3g2oA-3ptaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 LEU A1439
PRO A1440
LEU A1495
 None
 0.32A 3hcrA-3ptaA:
undetectable		 3hcrA-3ptaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ARG A 651
ASP A 701
GLN A1557
 None
 0.91A 3lcvB-3ptaA:
6.0		 3lcvB-3ptaA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 9 ARG A1312
ASN A1267
ALA A1313
LEU A1341
VAL A1272
 None
 1.41A 3o01A-3ptaA:
undetectable
3o01B-3ptaA:
undetectable		 3o01A-3ptaA:
15.87
3o01B-3ptaA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 LYS A 984
ARG A1337
LYS A 975
 None
 1.14A 3okxA-3ptaA:
undetectable		 3okxA-3ptaA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 8 TYR A1254
GLU A1189
LEU A1142
PHE A1187
 None
 1.01A 3rqwC-3ptaA:
undetectable
3rqwD-3ptaA:
undetectable		 3rqwC-3ptaA:
15.66
3rqwD-3ptaA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 8 TYR A1254
GLU A1189
LEU A1142
PHE A1187
 None
 1.00A 3rqwI-3ptaA:
undetectable
3rqwJ-3ptaA:
undetectable		 3rqwI-3ptaA:
15.66
3rqwJ-3ptaA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 8 GLU A1189
LEU A1142
PHE A1187
TYR A1254
 None
 0.98A 3rqwF-3ptaA:
undetectable
3rqwJ-3ptaA:
undetectable		 3rqwF-3ptaA:
15.66
3rqwJ-3ptaA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 8 LEU A1264
PHE A1155
VAL A1580
LEU A1584
 None
None
SAH  A1601 (-4.4A)
None
 0.84A 3uniB-3ptaA:
undetectable		 3uniB-3ptaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 GLY A1147
GLU A1168
ASP A1190
ASP A1143
 SAH  A1601 (-3.5A)
SAH  A1601 (-3.0A)
SAH  A1601 ( 4.7A)
None
 0.85A 3vywC-3ptaA:
7.5		 3vywC-3ptaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ARG A1574
ARG A 650
TRP A1170
 None
None
SAH  A1601 (-4.9A)
 1.25A 4b7nA-3ptaA:
undetectable		 4b7nA-3ptaA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ARG A1574
ARG A 650
TRP A1170
 None
None
SAH  A1601 (-4.9A)
 1.18A 4cpzE-3ptaA:
undetectable		 4cpzE-3ptaA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 VAL A1249
LEU A1252
SER A1250
MET A 849
 None
 1.31A 4e1gA-3ptaA:
undetectable		 4e1gA-3ptaA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ILE A1314
LEU A1151
GLY A1222
VAL A1580
ALA A1579
 None
SAH  A1601 (-3.6A)
None
SAH  A1601 (-4.4A)
SAH  A1601 (-4.7A)
 1.23A 4foxD-3ptaA:
undetectable		 4foxD-3ptaA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 TRP A1436
ALA A1511
GLY A1537
GLY A1515
LEU A1540
 None
 1.10A 4lg1A-3ptaA:
8.2		 4lg1A-3ptaA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 TRP A1436
ALA A1511
GLY A1537
GLY A1515
LEU A1540
 None
 1.13A 4lg1B-3ptaA:
8.1		 4lg1B-3ptaA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ALA A1554
GLY A1150
ASN A1180
GLU A1168
ALA A1579
 None
SAH  A1601 (-3.6A)
None
SAH  A1601 (-3.0A)
SAH  A1601 (-4.7A)
 1.19A 4pclA-3ptaA:
9.2		 4pclA-3ptaA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ARG A1437
ASP A1435
TRP A1436
 None
 1.08A 4xdqA-3ptaA:
undetectable		 4xdqA-3ptaA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A1297
THR A1295
ASN A1353
ILE A1315
ILE A1588
 None
 1.10A 4zvmA-3ptaA:
3.1
4zvmB-3ptaA:
3.7		 4zvmA-3ptaA:
13.56
4zvmB-3ptaA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ALA A1166
GLY A1149
GLY A1222
LEU A1151
ALA A1176
 None
SAH  A1601 ( 4.8A)
None
SAH  A1601 (-3.6A)
None
 0.99A 5c0oE-3ptaA:
9.2		 5c0oE-3ptaA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ARG A1456
ASN A1441
ASP A 965
 None
 0.88A 5gwxA-3ptaA:
9.1		 5gwxA-3ptaA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASP A1190
PRO A1225
PHE A1145
GLY A1147
GLU A1168
 SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 (-3.0A)
 0.55A 5hfjA-3ptaA:
5.5		 5hfjA-3ptaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASP A1190
PRO A1225
PHE A1145
GLY A1147
GLU A1168
 SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 (-3.0A)
 0.47A 5hfjD-3ptaA:
undetectable		 5hfjD-3ptaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASP A1190
PRO A1225
PHE A1145
GLY A1147
GLU A1168
 SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 (-3.0A)
 0.65A 5hfjF-3ptaA:
2.2		 5hfjF-3ptaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 11 PHE A1145
GLY A1147
GLU A1168
ASP A1190
PRO A1225
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 (-3.0A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
 0.63A 5hjiA-3ptaA:
8.6		 5hjiA-3ptaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 GLY A 654
CYH A 659
CYH A 656
 None
ZN  A   2 (-2.4A)
ZN  A   2 (-2.2A)
 0.86A 5inzB-3ptaA:
undetectable		 5inzB-3ptaA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 4 GLU A1591
PRO A1325
ILE A1592
LEU A1594
 None
 1.36A 5m45D-3ptaA:
undetectable		 5m45D-3ptaA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 PHE A1145
GLY A1147
ASP A1190
ASN A1578
VAL A1580
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-4.4A)
 0.59A 6mhtA-3ptaA:
25.0		 6mhtA-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 PHE A1145
GLY A1147
GLY A1150
ASP A1190
VAL A1580
 SAH  A1601 (-4.4A)
SAH  A1601 (-3.5A)
SAH  A1601 (-3.6A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.4A)
 0.75A 6mhtA-3ptaA:
25.0		 6mhtA-3ptaA:
16.08