SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ptk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 TYR A 112
SER A  27
TYR A 159
ILE A  95
PHE A 164
 None
 1.38A 1fmlA-3ptkA:
undetectable		 1fmlA-3ptkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 5 PHE A 440
LEU A 484
MET A  78
LEU A 121
 None
 0.97A 1skxA-3ptkA:
undetectable		 1skxA-3ptkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 ILE A  55
ALA A  64
GLY A 453
SER A  67
ASN A  60
 None
 1.08A 2okcA-3ptkA:
undetectable		 2okcA-3ptkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 ILE A  55
ALA A  64
GLY A 453
SER A  67
ASN A  60
 None
 1.11A 2okcB-3ptkA:
undetectable		 2okcB-3ptkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 11 ASN A 178
GLU A 179
TYR A 322
GLU A 393
TRP A 442
 TRS  A1164 ( 4.6A)
TRS  A1164 (-2.9A)
TRS  A1164 (-4.6A)
TRS  A1164 (-3.2A)
TRS  A1164 (-3.6A)
 0.76A 2v3dB-3ptkA:
2.7		 2v3dB-3ptkA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 GLY A 168
LEU A 116
ASN A 173
PRO A 127
PHE A  88
 None
 1.04A 2y7hB-3ptkA:
undetectable		 2y7hB-3ptkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 GLY A 168
LEU A 116
ASN A 173
PRO A 127
PHE A  88
 None
 1.03A 2y7hC-3ptkA:
undetectable		 2y7hC-3ptkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 7 PHE A  15
PHE A  21
TYR A 439
GLY A 318
 None
 1.00A 3em0B-3ptkA:
undetectable		 3em0B-3ptkA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 8 GLY A 209
PHE A 132
GLY A 187
PHE A 183
 None
 0.99A 3ko0O-3ptkA:
undetectable
3ko0Q-3ptkA:
undetectable		 3ko0O-3ptkA:
11.90
3ko0Q-3ptkA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		3 / 3 HIS A 422
PHE A 483
PHE A 480
 None
 0.62A 3lk0D-3ptkA:
undetectable		 3lk0D-3ptkA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 6 ILE A 153
ALA A 225
THR A 229
ALA A 160
 None
 0.76A 3mdrB-3ptkA:
undetectable		 3mdrB-3ptkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 6 ILE A 317
HIS A 226
PRO A 180
LEU A 249
 None
 1.14A 3oi8A-3ptkA:
undetectable		 3oi8A-3ptkA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		3 / 3 TYR A  68
ASP A  66
ASP A  62
 None
ZN  A 487 (-2.2A)
None
 0.95A 3ou7B-3ptkA:
undetectable		 3ou7B-3ptkA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		3 / 3 ARG A 471
LEU A  77
THR A  23
 None
 0.76A 3oxcA-3ptkA:
undetectable		 3oxcA-3ptkA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		3 / 3 TYR A 379
ASP A 272
ASP A 265
 None
 0.49A 4a6eA-3ptkA:
undetectable		 4a6eA-3ptkA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 ILE A 271
GLY A 276
ASP A 280
TYR A 379
LEU A 249
 None
 0.93A 4a81A-3ptkA:
undetectable		 4a81A-3ptkA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 ILE A 271
GLY A 276
ILE A 283
TYR A 379
LEU A 249
 None
 1.04A 4a81A-3ptkA:
undetectable		 4a81A-3ptkA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 7 GLY A  32
ASP A  62
GLY A  61
HIS A  49
 None
 0.79A 4c5nA-3ptkA:
undetectable		 4c5nA-3ptkA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 8 GLY A  32
ASP A  62
GLY A  61
HIS A  49
 None
 0.78A 4c5nC-3ptkA:
2.1		 4c5nC-3ptkA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		3 / 3 LYS A 236
LEU A 232
ALA A 235
 None
 0.80A 4iizA-3ptkA:
undetectable		 4iizA-3ptkA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		3 / 3 ASP A 135
TRP A 442
SER A  89
 None
TRS  A1164 (-3.6A)
None
 0.99A 4lrhB-3ptkA:
undetectable		 4lrhB-3ptkA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		3 / 3 ASP A 135
TRP A 442
SER A  89
 None
TRS  A1164 (-3.6A)
None
 1.06A 4lrhF-3ptkA:
undetectable		 4lrhF-3ptkA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 6 ASP A  62
ASP A  45
SER A  91
ALA A  64
 None
 0.98A 4nedA-3ptkA:
undetectable		 4nedA-3ptkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		3 / 3 ASN A 178
PHE A 440
TYR A  86
 TRS  A1164 ( 4.6A)
None
None
 0.69A 4u15A-3ptkA:
undetectable		 4u15A-3ptkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 TYR A  71
TYR A  28
ASP A  66
ALA A  64
TYR A 454
 None
None
ZN  A 487 (-2.2A)
None
None
 1.38A 4ymgB-3ptkA:
undetectable		 4ymgB-3ptkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 6 ILE A 110
GLY A  99
ASN A  98
ILE A 162
 None
 0.96A 5j4nB-3ptkA:
undetectable		 5j4nB-3ptkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 8 GLU A 417
PRO A 370
GLY A 358
PRO A 359
 None
 1.06A 5kgpA-3ptkA:
0.7		 5kgpA-3ptkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 8 GLU A 417
PRO A 370
GLY A 358
PRO A 359
 None
 1.02A 5kgpB-3ptkA:
0.8		 5kgpB-3ptkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 7 SER A 363
ASP A 397
SER A 451
ASN A 452
 None
 1.15A 5l1fC-3ptkA:
undetectable		 5l1fC-3ptkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 GLY A 395
HIS A 422
ALA A 441
PHE A 480
ALA A  24
 None
 1.10A 5n0oB-3ptkA:
undetectable		 5n0oB-3ptkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		5 / 12 GLU A 228
VAL A 230
PHE A 147
SER A 136
GLY A  99
 None
 1.26A 5xipA-3ptkA:
undetectable		 5xipA-3ptkA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3ptk BETA-GLUCOSIDASE
OS4BGLU12
(Oryza
sativa) 		4 / 6 TRP A  92
LEU A 224
TYR A 144
GLN A 138
 None
 1.32A 6djzC-3ptkA:
undetectable		 6djzC-3ptkA:
17.24