SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ptw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 5 ASP A  51
GLU A  53
THR A  62
LEU A  56
 None
 1.10A 1u18B-3ptwA:
undetectable		 1u18B-3ptwA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 7 GLY A   5
SER A  84
PHE A   8
HIS A 100
 None
 1.02A 2ackA-3ptwA:
undetectable		 2ackA-3ptwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 GLY A 153
ALA A 174
GLY A 130
GLY A 129
ILE A 128
 None
 0.82A 2avvA-3ptwA:
undetectable		 2avvA-3ptwA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 LEU A  56
ASN A  57
LEU A  92
ARG A 116
MET A  18
 None
 1.23A 2oaxA-3ptwA:
undetectable		 2oaxA-3ptwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 LEU A  56
ASN A  57
LEU A  92
ARG A 116
MET A  18
 None
 1.11A 2oaxC-3ptwA:
undetectable		 2oaxC-3ptwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 8 ILE A  67
GLN A 248
LEU A 245
LEU A 112
GLY A 109
 None
 1.30A 2qqcH-3ptwA:
undetectable
2qqcK-3ptwA:
undetectable		 2qqcH-3ptwA:
16.67
2qqcK-3ptwA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 11 GLY A 153
ALA A 174
GLY A 130
GLY A 129
ILE A 128
 None
 0.87A 3ufnA-3ptwA:
undetectable		 3ufnA-3ptwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 5 GLU A 233
GLY A 232
TYR A 235
GLU A  94
 None
 0.89A 3w9tA-3ptwA:
undetectable		 3w9tA-3ptwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 6 GLU A 233
GLY A 232
TYR A 235
GLU A  94
 None
 0.89A 3w9tB-3ptwA:
undetectable		 3w9tB-3ptwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 5 GLU A 233
GLY A 232
TYR A 235
GLU A  94
 None
 0.89A 3w9tC-3ptwA:
undetectable		 3w9tC-3ptwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 5 GLU A 233
GLY A 232
TYR A 235
GLU A  94
 None
 0.88A 3w9tD-3ptwA:
undetectable		 3w9tD-3ptwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 6 GLU A 233
GLY A 232
TYR A 235
GLU A  94
 None
 0.90A 3w9tE-3ptwA:
undetectable		 3w9tE-3ptwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 6 GLU A 233
GLY A 232
TYR A 235
GLU A  94
 None
 0.88A 3w9tF-3ptwA:
undetectable		 3w9tF-3ptwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 5 GLU A 233
GLY A 232
TYR A 235
GLU A  94
 None
 0.88A 3w9tG-3ptwA:
undetectable		 3w9tG-3ptwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 4 LEU A 222
ALA A 234
ILE A 225
LYS A 221
 None
 1.46A 4eixA-3ptwA:
undetectable		 4eixA-3ptwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 ILE A 225
GLY A   5
ILE A 271
SER A  84
HIS A 100
 None
 1.13A 4iv0B-3ptwA:
undetectable		 4iv0B-3ptwA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 TYR A  95
SER A 101
LEU A 222
ILE A 241
LEU A 214
 None
 1.34A 4k38A-3ptwA:
undetectable
4k38D-3ptwA:
undetectable		 4k38A-3ptwA:
21.59
4k38D-3ptwA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 ILE A 225
GLY A   5
ILE A 271
SER A  84
HIS A 100
 None
 1.12A 4mwzA-3ptwA:
undetectable		 4mwzA-3ptwA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 7 GLY A  19
ALA A  76
ASP A 297
LEU A 298
ASP A  24
 None
 1.24A 4ogrE-3ptwA:
undetectable		 4ogrE-3ptwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 6 SER A  37
GLU A  38
GLY A  17
GLY A  19
 None
 0.75A 5cdnA-3ptwA:
3.0
5cdnB-3ptwA:
undetectable		 5cdnA-3ptwA:
22.25
5cdnB-3ptwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 6 SER A  37
GLU A  38
GLY A  17
GLY A  19
 None
 0.77A 5cdnR-3ptwA:
undetectable
5cdnS-3ptwA:
undetectable		 5cdnR-3ptwA:
22.25
5cdnS-3ptwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 ALA A  97
GLN A  14
PHE A   8
GLY A  10
THR A  62
 None
 1.25A 5hfjB-3ptwA:
undetectable		 5hfjB-3ptwA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 ILE A  66
GLY A  10
PHE A 198
ALA A  65
VAL A 113
 None
 1.10A 5n0rA-3ptwA:
undetectable		 5n0rA-3ptwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 ILE A  66
GLY A  10
PHE A 198
ALA A  65
VAL A 113
 None
 1.11A 5n0wA-3ptwA:
1.0		 5n0wA-3ptwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 ILE A  66
GLY A  10
PHE A 198
ALA A  65
VAL A 113
 None
 1.09A 5n4iA-3ptwA:
undetectable		 5n4iA-3ptwA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		6 / 10 LEU A  90
GLY A  93
TYR A  95
VAL A 226
TYR A 235
ASN A 229
 None
 1.41A 5tqrB-3ptwA:
undetectable		 5tqrB-3ptwA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		5 / 12 GLY A 153
ALA A 174
GLY A 130
GLY A 129
ILE A 128
 None
 0.88A 6dj1A-3ptwA:
undetectable		 6dj1A-3ptwA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 3ptw MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Clostridium
perfringens) 		4 / 7 GLY A  17
TYR A  15
GLU A 272
GLY A 276
 None
 0.97A 6n7fA-3ptwA:
undetectable		 6n7fA-3ptwA:
12.67