SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 771
VAL A 769
TRP A 868
 None
 0.87A 1av2A-3ptyA:
undetectable
1av2B-3ptyA:
undetectable		 1av2A-3ptyA:
3.98
1av2B-3ptyA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 868
ALA A 771
VAL A 769
 None
 0.86A 1bdwA-3ptyA:
undetectable
1bdwB-3ptyA:
undetectable		 1bdwA-3ptyA:
3.98
1bdwB-3ptyA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 771
GLY A 780
LEU A 898
LEU A 945
LEU A 871
 None
 0.98A 1eizA-3ptyA:
undetectable		 1eizA-3ptyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 771
GLY A 780
LEU A 898
LEU A 945
LEU A 871
 None
 0.98A 1ej0A-3ptyA:
undetectable		 1ej0A-3ptyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 891
ARG A 927
ALA A 887
ILE A 790
 None
 1.00A 1oniA-3ptyA:
undetectable
1oniB-3ptyA:
undetectable		 1oniA-3ptyA:
18.81
1oniB-3ptyA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 960
GLY A 889
ALA A 888
GLY A 921
VAL A 885
 None
 0.95A 2ieoA-3ptyA:
undetectable		 2ieoA-3ptyA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 892
ASP A 919
ASP A 949
 None
None
CA  A1125 (-2.3A)
 0.79A 2igtB-3ptyA:
undetectable		 2igtB-3ptyA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 744
VAL A 736
LEU A1049
ASP A1052
ASP A1051
 None
AFO  A   1 ( 4.9A)
None
None
AFO  A   1 (-4.7A)
 1.17A 2q72A-3ptyA:
undetectable		 2q72A-3ptyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 744
VAL A 736
LEU A1049
ASP A1052
ASP A1051
 None
AFO  A   1 ( 4.9A)
None
None
AFO  A   1 (-4.7A)
 1.15A 2qb4A-3ptyA:
undetectable		 2qb4A-3ptyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 839
PRO A 840
LEU A 843
 None
 0.39A 2qd5B-3ptyA:
undetectable		 2qd5B-3ptyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 744
VAL A 736
LEU A1049
ASP A1052
ASP A1051
 None
AFO  A   1 ( 4.9A)
None
None
AFO  A   1 (-4.7A)
 1.16A 2qeiA-3ptyA:
undetectable		 2qeiA-3ptyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 PRO A1007
LEU A1063
LEU A 983
ILE A1011
ALA A1059
 None
 1.10A 3a50D-3ptyA:
undetectable		 3a50D-3ptyA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 960
GLY A 889
ALA A 888
GLY A 921
VAL A 885
 None
 0.89A 3em3A-3ptyA:
undetectable		 3em3A-3ptyA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 789
ALA A 792
PRO A 787
PHE A 785
ALA A 856
 None
 0.94A 3jb2A-3ptyA:
undetectable		 3jb2A-3ptyA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 976
TRP A1009
VAL A 981
 None
 0.72A 3n62B-3ptyA:
undetectable		 3n62B-3ptyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 976
TRP A1009
VAL A 981
 None
 0.72A 3n65B-3ptyA:
undetectable		 3n65B-3ptyA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 976
TRP A1009
VAL A 981
 None
 0.74A 3n66B-3ptyA:
undetectable		 3n66B-3ptyA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		4 / 7 SER A1047
VAL A1045
VAL A 757
LEU A 971
 None
 0.82A 3o14A-3ptyA:
1.5		 3o14A-3ptyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 839
PRO A 840
LEU A 843
 None
 0.40A 3w1wB-3ptyA:
undetectable		 3w1wB-3ptyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 960
GLY A 889
ALA A 888
GLY A 921
VAL A 885
 None
 0.92A 4dqbB-3ptyA:
undetectable		 4dqbB-3ptyA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 960
GLY A 889
ALA A 888
GLY A 921
VAL A 885
 None
 0.93A 4dqeB-3ptyA:
undetectable		 4dqeB-3ptyA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 960
GLY A 889
ALA A 888
GLY A 921
VAL A 885
 None
 0.90A 4dqhB-3ptyA:
undetectable		 4dqhB-3ptyA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 867
GLY A 778
LEU A 945
LEU A 864
ALA A 771
 None
 1.15A 4lg1C-3ptyA:
undetectable		 4lg1C-3ptyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 SER A 835
ALA A 959
GLY A 825
ALA A 837
THR A 827
 None
 1.07A 4qvnH-3ptyA:
undetectable
4qvnN-3ptyA:
undetectable		 4qvnH-3ptyA:
21.66
4qvnN-3ptyA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 947
VAL A 850
GLY A 889
SER A 853
GLY A 789
 None
None
None
CA  A1125 ( 4.7A)
None
 1.28A 4xp4A-3ptyA:
undetectable		 4xp4A-3ptyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 885
SER A 866
MET A 863
 None
 0.85A 5ikqA-3ptyA:
undetectable		 5ikqA-3ptyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 766
TYR A 869
MET A 765
LEU A 883
 None
 1.09A 5jq7B-3ptyA:
undetectable		 5jq7B-3ptyA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 976
TRP A1009
VAL A 981
 None
 0.72A 5vuoB-3ptyA:
undetectable		 5vuoB-3ptyA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 936
LEU A 933
ARG A 944
LEU A 766
 None
 0.96A 5xdqA-3ptyA:
undetectable
5xdqJ-3ptyA:
undetectable		 5xdqA-3ptyA:
22.01
5xdqJ-3ptyA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 936
LEU A 933
ARG A 944
LEU A 766
 None
 0.97A 5zcqA-3ptyA:
undetectable
5zcqJ-3ptyA:
undetectable		 5zcqA-3ptyA:
22.01
5zcqJ-3ptyA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 SER A 835
ALA A 959
GLY A 825
ALA A 837
THR A 827
 None
 1.07A 6hwdV-3ptyA:
undetectable
6hwdb-3ptyA:
undetectable		 6hwdV-3ptyA:
11.03
6hwdb-3ptyA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 3pty ARABINOSYLTRANSFERAS
E C
(Mycobacterium
tuberculosis) 		5 / 12 SER A 835
ALA A 959
GLY A 825
ALA A 837
THR A 827
 None
 1.07A 6hwdH-3ptyA:
undetectable
6hwdN-3ptyA:
undetectable		 6hwdH-3ptyA:
11.03
6hwdN-3ptyA:
13.27