SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pu9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		4 / 5 LEU A 118
GLY A 181
ILE A 193
ILE A 157
 None
 0.80A 2q9rA-3pu9A:
undetectable		 2q9rA-3pu9A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		4 / 5 LEU A 174
ASP A 205
ALA A 204
ILE A 164
 None
 1.13A 2qhfA-3pu9A:
undetectable		 2qhfA-3pu9A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		5 / 12 ASP A  96
VAL A 115
SER A 113
LEU A 158
GLN A 127
 None
 1.37A 3mbhB-3pu9A:
undetectable		 3mbhB-3pu9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		5 / 12 ASP A  96
VAL A 115
SER A 113
LEU A 158
GLN A 127
 None
 1.32A 3mbhC-3pu9A:
2.1		 3mbhC-3pu9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		5 / 12 ASP A  96
VAL A 115
SER A 113
LEU A 158
GLN A 127
 None
 1.34A 3mbhD-3pu9A:
2.0		 3mbhD-3pu9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		5 / 12 ASP A  96
VAL A 115
SER A 113
LEU A 158
GLN A 127
 None
 1.32A 3mbhE-3pu9A:
2.2		 3mbhE-3pu9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		4 / 5 ASP A 211
SER A  47
GLY A  46
ASP A 161
 MG  A 301 (-2.8A)
None
MG  A 302 (-4.1A)
MG  A 301 (-2.5A)
 1.01A 3w9tB-3pu9A:
undetectable		 3w9tB-3pu9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		4 / 5 ASP A 211
SER A  47
GLY A  46
ASP A 161
 MG  A 301 (-2.8A)
None
MG  A 302 (-4.1A)
MG  A 301 (-2.5A)
 1.02A 3w9tC-3pu9A:
undetectable		 3w9tC-3pu9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		4 / 5 ASP A 211
SER A  47
GLY A  46
ASP A 161
 MG  A 301 (-2.8A)
None
MG  A 302 (-4.1A)
MG  A 301 (-2.5A)
 1.02A 3w9tD-3pu9A:
undetectable		 3w9tD-3pu9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		5 / 11 ILE A 157
ALA A 200
ALA A 201
ILE A 164
VAL A 159
 None
 1.14A 4h1nA-3pu9A:
undetectable		 4h1nA-3pu9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		5 / 12 ALA A  94
GLY A  44
ASP A 212
ILE A 135
GLY A 133
 None
MG  A 302 (-4.3A)
None
None
None
 0.89A 4obwB-3pu9A:
undetectable		 4obwB-3pu9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		4 / 6 MET A 213
GLU A 199
GLY A 167
GLY A 168
 None
 0.86A 5x7pB-3pu9A:
undetectable		 5x7pB-3pu9A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		5 / 9 GLN A 127
LEU A 197
PHE A 176
LEU A 177
VAL A 159
 None
 1.46A 6ftpA-3pu9A:
undetectable
6ftpB-3pu9A:
undetectable		 6ftpA-3pu9A:
14.89
6ftpB-3pu9A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE
(Sphaerobacter
thermophilus) 		5 / 10 SER A 131
GLY A 132
ALA A  76
LEU A  95
LEU A 234
 None
 1.37A 6hqbA-3pu9A:
undetectable
6hqbJ-3pu9A:
undetectable		 6hqbA-3pu9A:
16.39
6hqbJ-3pu9A:
10.97