SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3puf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO7_B_CHDB503_0 (FERROCHELATASE, MITOCHONDRIAL)	3puf	RIBONUCLEASE H2 SUBUNIT B (Homo sapiens)	3 / 3	LEU B 94 PRO B 93 LEU B 97	None	0.51A	2po7B-3pufB: undetectable	2po7B-3pufB: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RCT_A_RTLA140_0 (RETINOL-BINDING PROTEIN II, CELLULAR)	3puf	RIBONUCLEASE H2 SUBUNIT B (Homo sapiens)	5 / 12	ALA B 104 THR B 142 TYR B 156 LEU B 113 LEU B 94	None	1.22A	2rctA-3pufB: undetectable	2rctA-3pufB: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCR_A_CHDA4_0 (FERROCHELATASE, MITOCHONDRIAL)	3puf	RIBONUCLEASE H2 SUBUNIT B (Homo sapiens)	3 / 3	LEU B 94 PRO B 93 LEU B 97	None	0.48A	3hcrA-3pufB: undetectable	3hcrA-3pufB: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UM5_A_CP6A609_1 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	3puf	RIBONUCLEASE H2 SUBUNIT B (Homo sapiens)	5 / 10	ILE B 220 PHE B 95 THR B 174 ILE B 216 THR B 163	None	1.36A	3um5A-3pufB: undetectable	3um5A-3pufB: 16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UM5_B_CP6B709_1 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	3puf	RIBONUCLEASE H2 SUBUNIT B (Homo sapiens)	5 / 10	ILE B 220 PHE B 95 THR B 174 ILE B 216 THR B 163	None	1.34A	3um5B-3pufB: undetectable	3um5B-3pufB: 16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PEV_A_ADNA501_2 (MEMBRANE LIPOPROTEIN FAMILY PROTEIN)	3puf	RIBONUCLEASE H2 SUBUNIT B (Homo sapiens)	3 / 3	PRO B 93 LEU B 94 HIS B 139	None	0.70A	4pevA-3pufB: undetectable	4pevA-3pufB: 17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZU_B_RTLB201_0 (RETINOL-BINDING PROTEIN 2)	3puf	RIBONUCLEASE H2 SUBUNIT B (Homo sapiens)	5 / 12	ALA B 104 THR B 142 TYR B 156 LEU B 113 LEU B 94	None	1.35A	4qzuB-3pufB: undetectable	4qzuB-3pufB: 17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZU_C_RTLC201_0 (RETINOL-BINDING PROTEIN 2)	3puf	RIBONUCLEASE H2 SUBUNIT B (Homo sapiens)	5 / 12	ALA B 104 THR B 142 TYR B 156 LEU B 113 LEU B 94	None	1.08A	4qzuC-3pufB: undetectable	4qzuC-3pufB: 17.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2PO7_B_CHDB503_0","FERROCHELATASE, MITOCHONDRIAL","3puf","RIBONUCLEASE H2 SUBUNIT B","Homo sapiens",3,"LEU B  94;PRO B  93;LEU B  97","None","0.51A","2po7B-3pufB:undetectable","2po7B-3pufB:20.39"],["2RCT_A_RTLA140_0","RETINOL-BINDING PROTEIN II, CELLULAR","3puf","RIBONUCLEASE H2 SUBUNIT B","Homo sapiens",5,"ALA B 104;THR B 142;TYR B 156;LEU B 113;LEU B  94","None","1.22A","2rctA-3pufB:undetectable","2rctA-3pufB:18.97"],["3HCR_A_CHDA4_0","FERROCHELATASE, MITOCHONDRIAL","3puf","RIBONUCLEASE H2 SUBUNIT B","Homo sapiens",3,"LEU B  94;PRO B  93;LEU B  97","None","0.48A","3hcrA-3pufB:undetectable","3hcrA-3pufB:20.39"],["3UM5_A_CP6A609_1","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","3puf","RIBONUCLEASE H2 SUBUNIT B","Homo sapiens",5,"ILE B 220;PHE B  95;THR B 174;ILE B 216;THR B 163","None","1.36A","3um5A-3pufB:undetectable","3um5A-3pufB:16.20"],["3UM5_B_CP6B709_1","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","3puf","RIBONUCLEASE H2 SUBUNIT B","Homo sapiens",5,"ILE B 220;PHE B  95;THR B 174;ILE B 216;THR B 163","None","1.34A","3um5B-3pufB:undetectable","3um5B-3pufB:16.20"],["4PEV_A_ADNA501_2","MEMBRANE LIPOPROTEIN FAMILY PROTEIN","3puf","RIBONUCLEASE H2 SUBUNIT B","Homo sapiens",3,"PRO B  93;LEU B  94;HIS B 139","None","0.70A","4pevA-3pufB:undetectable","4pevA-3pufB:17.97"],["4QZU_B_RTLB201_0","RETINOL-BINDING PROTEIN 2","3puf","RIBONUCLEASE H2 SUBUNIT B","Homo sapiens",5,"ALA B 104;THR B 142;TYR B 156;LEU B 113;LEU B  94","None","1.35A","4qzuB-3pufB:undetectable","4qzuB-3pufB:17.83"],["4QZU_C_RTLC201_0","RETINOL-BINDING PROTEIN 2","3puf","RIBONUCLEASE H2 SUBUNIT B","Homo sapiens",5,"ALA B 104;THR B 142;TYR B 156;LEU B 113;LEU B  94","None","1.08A","4qzuC-3pufB:undetectable","4qzuC-3pufB:17.83"]]