SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
(Homo
sapiens) 		3 / 3 ALA A  88
VAL A  78
TRP A  65
 None
 0.82A 1tkqA-3pv6A:
undetectable		 1tkqA-3pv6A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
(Homo
sapiens) 		4 / 6 LEU A  56
GLY A 103
ASN A  49
PHE A  51
 None
 0.70A 1xf1B-3pv6A:
3.0		 1xf1B-3pv6A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
(Homo
sapiens) 		5 / 12 GLY A  92
ALA A  93
ILE A  46
VAL A  76
VAL A  78
 None
 0.98A 2nnkA-3pv6A:
undetectable		 2nnkA-3pv6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3
(Homo
sapiens) 		5 / 12 SER A  60
TYR A  52
LEU A  56
ILE A  63
LEU B  86
 None
 1.50A 2xkwA-3pv6A:
undetectable		 2xkwA-3pv6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
(Homo
sapiens) 		3 / 3 LEU A  40
TRP A  67
TYR A 169
 None
 1.01A 3aicA-3pv6A:
undetectable		 3aicA-3pv6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
(Homo
sapiens) 		3 / 3 LEU A  40
TRP A  67
TYR A 169
 None
 0.98A 3aicB-3pv6A:
undetectable		 3aicB-3pv6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
(Homo
sapiens) 		3 / 3 LEU A  40
TRP A  67
TYR A 169
 None
 0.99A 3aicE-3pv6A:
undetectable		 3aicE-3pv6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
(Homo
sapiens) 		3 / 3 LEU A  40
TRP A  67
TYR A 169
 None
 0.97A 3aicF-3pv6A:
undetectable		 3aicF-3pv6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
(Homo
sapiens) 		3 / 3 LEU A  40
TRP A  67
TYR A 169
 None
 0.98A 3aicG-3pv6A:
undetectable		 3aicG-3pv6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3pv6 NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3
(Homo
sapiens) 		5 / 12 ALA B  91
ALA B  49
GLY B 116
GLU B 111
VAL B 107
 None
 1.06A 3c6gB-3pv6B:
undetectable		 3c6gB-3pv6B:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
(Homo
sapiens) 		5 / 12 LEU A 147
THR A 224
THR A 181
LEU A 215
ILE A 190
 None
 1.12A 3sp9A-3pv6A:
undetectable		 3sp9A-3pv6A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3
(Homo
sapiens;
Homo
sapiens) 		4 / 7 VAL A 125
ILE A  58
SER B  82
THR A 127
 None
 0.88A 5vkqA-3pv6A:
undetectable
5vkqD-3pv6A:
undetectable		 5vkqA-3pv6A:
9.80
5vkqD-3pv6A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3
(Homo
sapiens;
Homo
sapiens) 		5 / 12 SER A  60
TYR A  52
LEU A  56
ILE A  63
LEU B  86
 None
 1.39A 5ycpA-3pv6A:
undetectable		 5ycpA-3pv6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3pv6 NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3
(Homo
sapiens) 		4 / 6 PHE B  41
ARG B 109
LEU B  19
ALA B  43
 None
 1.01A 6b89B-3pv6B:
undetectable		 6b89B-3pv6B:
17.95