SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pvd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 3pvd CAPSID
(Norwalk
virus) 		3 / 3 ASP A 247
PHE A 242
ASN A 443
 None
 0.83A 1sg9B-3pvdA:
undetectable		 1sg9B-3pvdA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3pvd CAPSID
(Norwalk
virus) 		5 / 12 LEU A 415
GLY A 321
LEU A 323
GLY A 324
PRO A 261
 None
 1.21A 1y4lA-3pvdA:
undetectable		 1y4lA-3pvdA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 3pvd CAPSID
(Norwalk
virus) 		4 / 6 ARG A 432
PHE A 431
ILE A 234
PHE A 512
 None
 1.25A 2qeiA-3pvdA:
undetectable		 2qeiA-3pvdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3pvd CAPSID
(Norwalk
virus) 		4 / 7 THR A 319
PRO A 320
GLY A 321
LEU A 272
 None
 0.98A 2vl2B-3pvdA:
undetectable		 2vl2B-3pvdA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3pvd CAPSID
(Norwalk
virus) 		5 / 11 THR A 275
GLY A 321
GLY A 324
PHE A 286
PRO A 403
 None
 1.43A 2y7kA-3pvdA:
undetectable		 2y7kA-3pvdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3pvd CAPSID
(Norwalk
virus) 		5 / 12 THR A 275
GLY A 321
GLY A 324
PHE A 286
PRO A 403
 None
 1.32A 2y7kC-3pvdA:
undetectable		 2y7kC-3pvdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3pvd CAPSID
(Norwalk
virus) 		5 / 12 THR A 442
ILE A 388
GLY A 437
GLY A 440
ARG A 351
 None
 1.18A 2y7kC-3pvdA:
undetectable		 2y7kC-3pvdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3pvd CAPSID
(Norwalk
virus) 		5 / 10 THR A 275
GLY A 321
GLY A 324
PHE A 286
PRO A 403
 None
 1.48A 2y7pA-3pvdA:
undetectable		 2y7pA-3pvdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3pvd CAPSID
(Norwalk
virus) 		5 / 9 THR A 442
ILE A 388
GLY A 437
GLY A 440
ARG A 351
 None
 1.27A 2y7wA-3pvdA:
undetectable		 2y7wA-3pvdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3pvd CAPSID
(Norwalk
virus) 		4 / 4 LEU A 449
ASP A 269
VAL A 455
THR A 276
 None
 1.21A 3cyxB-3pvdA:
undetectable		 3cyxB-3pvdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 3pvd CAPSID
(Norwalk
virus) 		5 / 12 GLY A 324
GLY A 364
GLN A 304
ASN A 285
LEU A 323
 None
 1.10A 3eeyH-3pvdA:
undetectable		 3eeyH-3pvdA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 3pvd CAPSID
(Norwalk
virus) 		4 / 7 PHE A 512
MET A 494
MET A 237
ILE A 234
 None
 0.98A 3rfmA-3pvdA:
undetectable		 3rfmA-3pvdA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3pvd CAPSID
(Norwalk
virus) 		4 / 7 ASN A 413
LEU A 415
GLY A 406
TYR A 405
 None
 0.67A 4cp3A-3pvdA:
undetectable
4cp3B-3pvdA:
undetectable		 4cp3A-3pvdA:
16.72
4cp3B-3pvdA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3pvd CAPSID
(Norwalk
virus) 		4 / 5 TYR A 389
THR A 381
LEU A 303
THR A 354
 None
 1.46A 4mbsB-3pvdA:
undetectable		 4mbsB-3pvdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3pvd CAPSID
(Norwalk
virus) 		4 / 5 TYR A 522
GLU A 485
GLU A 515
PHE A 514
 None
 1.44A 4twdA-3pvdA:
0.0
4twdB-3pvdA:
0.0		 4twdA-3pvdA:
22.70
4twdB-3pvdA:
22.70