SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3pve AGRIN, AGRIN PROTEIN
(Mus
musculus) 		4 / 6 PHE A1461
LEU A1469
ALA A1628
ALA A1459
 None
 0.91A 2vcvB-3pveA:
undetectable		 2vcvB-3pveA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3pve AGRIN, AGRIN PROTEIN
(Mus
musculus) 		4 / 6 PHE A1461
LEU A1469
ALA A1628
ALA A1459
 None
 0.91A 2vcvK-3pveA:
undetectable		 2vcvK-3pveA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3pve AGRIN, AGRIN PROTEIN
(Mus
musculus) 		4 / 7 TYR A1500
GLY A1604
VAL A1601
ASP A1606
 None
 0.94A 2y05A-3pveA:
undetectable
2y05B-3pveA:
undetectable		 2y05A-3pveA:
21.94
2y05B-3pveA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3pve AGRIN, AGRIN PROTEIN
(Mus
musculus) 		4 / 7 ALA A1531
PHE A1511
ALA A1596
ALA A1600
 None
 0.92A 4du2A-3pveA:
undetectable		 4du2A-3pveA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3pve AGRIN, AGRIN PROTEIN
(Mus
musculus) 		4 / 7 ALA A1531
PHE A1511
ALA A1596
ALA A1600
 None
 0.88A 4du2B-3pveA:
undetectable		 4du2B-3pveA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 3pve AGRIN, AGRIN PROTEIN
(Mus
musculus) 		5 / 11 LEU A1497
PHE A1523
GLY A1502
LEU A1580
ALA A1599
 None
 1.30A 4wnuC-3pveA:
undetectable		 4wnuC-3pveA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3pve AGRIN, AGRIN PROTEIN
(Mus
musculus) 		4 / 6 GLU A1486
GLY A1493
ASP A1606
ARG A1492
 None
 0.88A 5cdnA-3pveA:
undetectable
5cdnB-3pveA:
undetectable		 5cdnA-3pveA:
17.76
5cdnB-3pveA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3pve AGRIN, AGRIN PROTEIN
(Mus
musculus) 		4 / 6 GLU A1486
GLY A1493
ASP A1606
ARG A1492
 None
 0.89A 5cdnT-3pveA:
undetectable
5cdnU-3pveA:
undetectable		 5cdnT-3pveA:
17.76
5cdnU-3pveA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3pve AGRIN, AGRIN PROTEIN
(Mus
musculus) 		4 / 6 TYR A1525
LEU A1580
GLY A1502
PHE A1511
 None
 0.97A 5nooC-3pveA:
undetectable		 5nooC-3pveA:
20.92