SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		5 / 12 ILE A 190
ALA A 222
THR A 196
ILE A 200
LEU A 174
 None
 1.12A 1dhfA-3pvsA:
undetectable		 1dhfA-3pvsA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		5 / 12 GLY A  60
ALA A  17
ALA A  18
THR A  65
THR A  64
 PO4  A 448 (-3.1A)
None
None
None
PO4  A 448 (-3.8A)
 1.04A 1gtnL-3pvsA:
undetectable
1gtnV-3pvsA:
undetectable		 1gtnL-3pvsA:
10.93
1gtnV-3pvsA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		5 / 12 GLU A 223
GLY A 329
ALA A 334
PHE A 321
LEU A 289
 None
 1.32A 1nw3A-3pvsA:
3.1		 1nw3A-3pvsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		5 / 11 ALA A  18
THR A  65
THR A  64
GLY A  60
ALA A  17
 None
None
PO4  A 448 (-3.8A)
PO4  A 448 (-3.1A)
None
 1.02A 1utdP-3pvsA:
undetectable
1utdQ-3pvsA:
undetectable		 1utdP-3pvsA:
10.93
1utdQ-3pvsA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		5 / 11 ARG A 280
ALA A 279
LEU A 262
ALA A 261
LEU A 275
 None
 1.09A 2bxeB-3pvsA:
2.0		 2bxeB-3pvsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		5 / 10 ALA A 140
ILE A 138
ILE A 135
ILE A  81
THR A 141
 None
 1.13A 3clbD-3pvsA:
undetectable		 3clbD-3pvsA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		5 / 10 ALA A 140
ILE A 138
ILE A 135
ILE A  81
THR A 141
 None
 1.11A 3hbbD-3pvsA:
undetectable		 3hbbD-3pvsA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		3 / 3 HIS A 116
PHE A 126
PHE A 137
 None
 0.79A 3lk0D-3pvsA:
1.6		 3lk0D-3pvsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		3 / 3 LYS A  39
PRO A  40
LEU A  41
 None
 0.81A 3tpxE-3pvsA:
undetectable		 3tpxE-3pvsA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		4 / 5 ASN A 305
PRO A 308
GLY A 304
ASP A 319
 None
 1.04A 4n48B-3pvsA:
undetectable		 4n48B-3pvsA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		3 / 3 ASP A 189
GLY A 228
ASP A 225
 None
 0.58A 4xdtA-3pvsA:
undetectable		 4xdtA-3pvsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		4 / 5 ALA A 352
TYR A 415
HIS A 371
PHE A 406
 None
 1.17A 4ze2A-3pvsA:
undetectable		 4ze2A-3pvsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A
(Escherichia
coli) 		4 / 6 ASP A 319
GLY A 325
PRO A 326
GLY A 329
 None
 0.75A 6ag0C-3pvsA:
undetectable		 6ag0C-3pvsA:
9.98