SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		4 / 6 VAL A 131
LEU A 221
ARG A 222
PHE A 225
 None
None
GOL  A 311 (-4.2A)
None
 0.94A 1s8fB-3pvtA:
undetectable		 1s8fB-3pvtA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		3 / 3 VAL A 125
TRP A 123
VAL A 120
 None
 0.92A 2izqA-3pvtA:
undetectable
2izqB-3pvtA:
undetectable		 2izqA-3pvtA:
7.10
2izqB-3pvtA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		4 / 7 GLU A 263
PHE A 264
TYR A 110
VAL A  44
 None
3HC  A 310 (-4.8A)
None
None
 1.07A 4a97D-3pvtA:
undetectable		 4a97D-3pvtA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		4 / 6 GLU A 263
PHE A 264
TYR A 110
VAL A  44
 None
3HC  A 310 (-4.8A)
None
None
 1.15A 4a97E-3pvtA:
undetectable		 4a97E-3pvtA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		4 / 7 GLY A 257
ILE A 259
ASN A 198
GLU A 258
 None
GOL  A 311 (-4.0A)
GOL  A 311 (-3.4A)
GOL  A 311 (-3.1A)
 1.09A 4g0vA-3pvtA:
undetectable		 4g0vA-3pvtA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		5 / 9 THR A  30
LEU A  31
LEU A  79
GLN A 133
THR A 139
 None
None
None
3HC  A 310 (-3.4A)
None
 1.45A 4ltwA-3pvtA:
2.1		 4ltwA-3pvtA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		4 / 4 VAL A 125
ALA A 129
ASN A 132
GLN A 133
 None
3HC  A 310 (-3.4A)
3HC  A 310 (-3.0A)
3HC  A 310 (-3.4A)
 1.45A 4zgfA-3pvtA:
undetectable		 4zgfA-3pvtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		5 / 12 ARG A 283
GLN A 276
TYR A 104
GLY A 270
GLY A 272
 None
 1.19A 5e3iA-3pvtA:
undetectable		 5e3iA-3pvtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		5 / 11 ARG A 283
GLN A 276
TYR A 104
GLY A 270
GLY A 272
 None
 1.19A 5e3iB-3pvtA:
undetectable		 5e3iB-3pvtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		4 / 8 ASN A 132
ALA A 135
GLN A 133
HIS A  38
 3HC  A 310 (-3.0A)
None
3HC  A 310 (-3.4A)
3HC  A 310 (-3.2A)
 1.10A 5km8A-3pvtA:
undetectable
5km8B-3pvtA:
undetectable		 5km8A-3pvtA:
17.80
5km8B-3pvtA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		5 / 12 LEU A  86
LEU A  31
LEU A 136
MET A 148
LEU A  79
 None
 1.20A 5mwyA-3pvtA:
2.0		 5mwyA-3pvtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		3 / 3 MET A 193
ASP A 260
ARG A 271
 None
 1.08A 5z6jA-3pvtA:
undetectable		 5z6jA-3pvtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		3 / 3 MET A 193
ASP A 260
ARG A 271
 None
 1.01A 5z6kA-3pvtA:
undetectable		 5z6kA-3pvtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA
(Escherichia
coli) 		4 / 6 GLU A  72
HIS A 158
ALA A  67
GLN A  70
 None
 1.48A 6f6jC-3pvtA:
undetectable
6f6jD-3pvtA:
undetectable		 6f6jC-3pvtA:
22.02
6f6jD-3pvtA:
22.02