SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		4 / 7 SER A  61
PHE A  64
LEU A  65
ALA A 114
 None
 0.77A 1j8uA-3pw3A:
undetectable		 1j8uA-3pw3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		5 / 11 LEU A 123
PHE A 206
LEU A  65
SER A  61
VAL A 388
 None
 1.38A 2po5B-3pw3A:
undetectable		 2po5B-3pw3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		4 / 7 VAL A 389
ALA A 259
PHE A 111
THR A 384
 None
None
EDO  A 434 ( 3.8A)
None
 0.95A 2q6oA-3pw3A:
undetectable		 2q6oA-3pw3A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		5 / 11 ALA A 259
LEU A 394
LEU A 247
TYR A 357
THR A 262
 None
 1.33A 2zzaB-3pw3A:
undetectable		 2zzaB-3pw3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		4 / 7 GLN A  50
GLY A  54
HIS A 340
TRP A 363
 ZN  A 406 ( 4.1A)
None
ZN  A 406 (-2.9A)
None
 0.35A 3ai8A-3pw3A:
15.6		 3ai8A-3pw3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		4 / 4 LEU A 186
ASP A  91
VAL A 178
THR A 149
 None
 1.26A 3cyxB-3pw3A:
undetectable		 3cyxB-3pw3A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		5 / 12 ALA A 259
LEU A 394
LEU A 247
TYR A 357
THR A 262
 None
 1.14A 3fl9G-3pw3A:
undetectable		 3fl9G-3pw3A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		5 / 11 THR A  45
LEU A  70
LEU A  69
GLY A  75
ASP A  78
 None
None
None
None
K  A 408 (-3.3A)
 1.13A 3lxiB-3pw3A:
undetectable		 3lxiB-3pw3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		3 / 3 VAL A 359
VAL A 272
SER A 270
 None
 0.60A 3n8xB-3pw3A:
undetectable		 3n8xB-3pw3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		4 / 8 ALA A  53
GLY A  54
THR A  55
GLN A 107
 None
 0.94A 3rglA-3pw3A:
undetectable		 3rglA-3pw3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		4 / 5 SER A 104
ARG A  92
TYR A  89
VAL A 153
 None
 1.39A 3sufC-3pw3A:
undetectable		 3sufC-3pw3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		4 / 8 ASN A 354
GLN A 317
ASN A 313
THR A 314
 None
 1.17A 4d1yA-3pw3A:
undetectable
4d1yB-3pw3A:
undetectable		 4d1yA-3pw3A:
18.86
4d1yB-3pw3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		5 / 10 ILE A 266
ALA A 393
PHE A 256
PRO A 248
ILE A 387
 None
 1.19A 4g8zX-3pw3A:
undetectable		 4g8zX-3pw3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		5 / 9 VAL A 284
ALA A 283
GLY A  33
PHE A  34
GLY A 281
 EDO  A 431 (-3.9A)
None
None
EDO  A 431 (-4.9A)
None
 1.02A 4mm5A-3pw3A:
undetectable		 4mm5A-3pw3A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		5 / 12 VAL A 284
ALA A 283
GLY A  33
PHE A  34
GLY A 281
 EDO  A 431 (-3.9A)
None
None
EDO  A 431 (-4.9A)
None
 1.09A 4mm8A-3pw3A:
undetectable		 4mm8A-3pw3A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		3 / 3 LEU A 219
MET A 253
TYR A 264
 None
 0.75A 4p6xG-3pw3A:
undetectable		 4p6xG-3pw3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3pw3 AMINOPEPTIDASE C
(Parabacteroides
distasonis) 		3 / 3 MET A 133
GLN A 183
TYR A  86
 None
 1.04A 4udcA-3pw3A:
undetectable		 4udcA-3pw3A:
22.08