SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		4 / 8 LEU A 169
HIS A 166
LEU A 137
LEU A 140
 None
 1.07A 1e7cA-3pwzA:
undetectable		 1e7cA-3pwzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		4 / 7 SER A  77
PHE A  91
ALA A  88
PHE A 101
 None
 1.17A 1fxvA-3pwzA:
undetectable
1fxvB-3pwzA:
undetectable		 1fxvA-3pwzA:
23.31
1fxvB-3pwzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 ASN A 113
GLY A 115
LEU A 118
THR A 260
ILE A 264
 None
 1.38A 1p93B-3pwzA:
undetectable		 1p93B-3pwzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		6 / 11 LEU A 205
ALA A 236
ALA A 211
VAL A 204
LEU A 177
LEU A 124
 None
 1.47A 1rlbF-3pwzA:
undetectable		 1rlbF-3pwzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 LEU A 160
LEU A 164
GLY A 134
ALA A  83
ALA A  85
 None
 1.10A 2br4E-3pwzA:
4.9		 2br4E-3pwzA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 11 LEU A  23
ILE A  20
VAL A 239
GLY A 240
LEU A 267
 None
 1.37A 2bxeA-3pwzA:
undetectable		 2bxeA-3pwzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 ALA A 131
LEU A 214
LEU A 125
ILE A 110
LEU A 118
 None
 1.16A 2oipD-3pwzA:
undetectable		 2oipD-3pwzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 11 LEU A 136
ARG A 133
ILE A 149
ALA A 159
ASP A 153
 None
 1.18A 2q72A-3pwzA:
undetectable		 2q72A-3pwzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 11 LEU A 136
ARG A 133
ILE A 149
ALA A 159
ASP A 153
 None
 1.12A 2qjuA-3pwzA:
undetectable		 2qjuA-3pwzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		3 / 3 TRP A 252
VAL A 256
TRP A 253
 None
 1.29A 2xdcC-3pwzA:
undetectable
2xdcD-3pwzA:
undetectable		 2xdcC-3pwzA:
3.01
2xdcD-3pwzA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		3 / 3 TRP A 252
VAL A 256
TRP A 253
 None
 1.32A 2xdcE-3pwzA:
undetectable
2xdcF-3pwzA:
undetectable		 2xdcE-3pwzA:
3.01
2xdcF-3pwzA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		3 / 3 TRP A 252
VAL A 256
TRP A 253
 None
 1.28A 2y5mE-3pwzA:
undetectable
2y5mF-3pwzA:
undetectable		 2y5mE-3pwzA:
3.01
2y5mF-3pwzA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		3 / 3 TRP A 252
VAL A 256
TRP A 253
 None
 1.30A 2y6nC-3pwzA:
undetectable
2y6nD-3pwzA:
undetectable		 2y6nC-3pwzA:
3.01
2y6nD-3pwzA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		3 / 3 TRP A 252
VAL A 256
TRP A 253
 None
 1.30A 2y6nE-3pwzA:
undetectable
2y6nF-3pwzA:
undetectable		 2y6nE-3pwzA:
3.01
2y6nF-3pwzA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 ALA A 131
LEU A 214
LEU A 125
ILE A 110
LEU A 118
 None
 1.14A 3datA-3pwzA:
undetectable		 3datA-3pwzA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 VAL A 186
ALA A 227
GLN A 230
LEU A 200
ALA A 202
 None
 0.99A 3fc6C-3pwzA:
undetectable		 3fc6C-3pwzA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 PHE A 223
LEU A 226
ALA A 227
LEU A 210
ILE A 184
 None
 0.90A 4dm8B-3pwzA:
undetectable		 4dm8B-3pwzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		4 / 8 LEU A 106
GLY A 103
GLU A 248
ALA A 249
 None
 0.89A 4rjdA-3pwzA:
undetectable
4rjdB-3pwzA:
undetectable		 4rjdA-3pwzA:
13.24
4rjdB-3pwzA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 TYR A 212
VAL A 186
LEU A 214
GLY A 103
ALA A 135
 None
 1.05A 4rrxA-3pwzA:
undetectable		 4rrxA-3pwzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 TYR A 212
VAL A 186
LEU A 214
GLY A 103
ALA A 135
 None
 1.06A 4rrxB-3pwzA:
undetectable		 4rrxB-3pwzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		4 / 5 ILE A  12
VAL A   7
PHE A 101
HIS A  14
 None
 1.09A 4rzvA-3pwzA:
undetectable		 4rzvA-3pwzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		4 / 7 LEU A 214
LEU A 125
LEU A 126
ILE A 184
 None
 0.80A 4ubsA-3pwzA:
undetectable		 4ubsA-3pwzA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		6 / 11 GLU A 175
ALA A 176
LEU A 177
LEU A 200
LEU A 126
LEU A 124
 None
 1.41A 4wg0C-3pwzA:
undetectable
4wg0D-3pwzA:
undetectable
4wg0E-3pwzA:
undetectable		 4wg0C-3pwzA:
4.62
4wg0D-3pwzA:
4.62
4wg0E-3pwzA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		6 / 11 GLU A 175
ALA A 176
LEU A 177
LEU A 200
LEU A 126
LEU A 124
 None
 1.40A 4wg0E-3pwzA:
undetectable
4wg0F-3pwzA:
undetectable
4wg0G-3pwzA:
undetectable		 4wg0E-3pwzA:
4.62
4wg0F-3pwzA:
4.62
4wg0G-3pwzA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		3 / 4 ARG A  10
GLY A   9
GLU A  38
 None
 0.66A 4z2dB-3pwzA:
undetectable
4z2dC-3pwzA:
2.5		 4z2dB-3pwzA:
22.09
4z2dC-3pwzA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 11 ALA A 249
GLU A 244
LEU A 242
PHE A  24
THR A 260
 None
 1.10A 4zmeA-3pwzA:
undetectable		 4zmeA-3pwzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 10 ALA A 249
GLU A 244
LEU A 242
PHE A  24
THR A 260
 None
 1.10A 4zmeB-3pwzA:
undetectable		 4zmeB-3pwzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 LEU A 210
ALA A 233
LEU A 224
LEU A 235
LEU A 205
 None
 1.13A 4zn7A-3pwzA:
undetectable		 4zn7A-3pwzA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 ILE A  61
ALA A  88
ALA A  80
ARG A  79
PHE A  44
 None
 1.47A 4zo1X-3pwzA:
undetectable		 4zo1X-3pwzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 LEU A 205
LEU A 147
LEU A 118
ALA A 188
LEU A 106
 None
 1.13A 5iepA-3pwzA:
undetectable		 5iepA-3pwzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		4 / 8 TRP A 253
ASN A  60
ALA A  88
HIS A  21
 None
 1.13A 5km8A-3pwzA:
undetectable
5km8B-3pwzA:
undetectable		 5km8A-3pwzA:
20.22
5km8B-3pwzA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		5 / 12 LEU A 125
GLY A 129
ALA A 128
ILE A 171
ILE A 149
 None
 0.79A 5t8hB-3pwzA:
undetectable		 5t8hB-3pwzA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3pwz SHIKIMATE
DEHYDROGENASE 3
(Pseudomonas
putida) 		4 / 5 ARG A  68
ALA A  69
GLN A  47
ILE A   8
 None
 1.15A 6g9bA-3pwzA:
undetectable
6g9bB-3pwzA:
undetectable		 6g9bA-3pwzA:
16.98
6g9bB-3pwzA:
14.50