SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3px2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
GLY A  60
SER A  81
MET A  84
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.72A 1kiaA-3px2A:
22.7		 1kiaA-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 GLY A  60
SER A  81
MET A  84
SER A 120
LEU A 124
 SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
None
 0.89A 1kiaD-3px2A:
19.8		 1kiaD-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
GLY A  60
SER A  81
SER A 120
LEU A 124
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-3.3A)
None
 0.89A 1kiaD-3px2A:
19.8		 1kiaD-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
GLY A  60
SER A  81
MET A  84
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.68A 1nbhA-3px2A:
19.9		 1nbhA-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
GLY A  60
SER A  81
MET A  84
LEU A 124
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
None
 0.93A 1nbhB-3px2A:
22.4		 1nbhB-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
GLY A  60
SER A  81
MET A  84
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.68A 1nbhC-3px2A:
22.3		 1nbhC-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
GLY A  60
SER A  81
MET A  84
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.69A 1nbhD-3px2A:
22.4		 1nbhD-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		6 / 12 TYR A  14
GLY A  60
THR A  61
SER A  81
MET A  84
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
None
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.73A 1nbiC-3px2A:
22.2		 1nbiC-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		6 / 12 TYR A  14
GLY A  60
THR A  61
SER A  81
MET A  84
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
None
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.74A 1nbiD-3px2A:
22.3		 1nbiD-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		3 / 3 GLU A 207
HIS A 205
HIS A 193
 None
 0.60A 1oe2A-3px2A:
undetectable		 1oe2A-3px2A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 LEU A 130
GLY A 126
GLN A 127
THR A 188
ILE A 212
 None
None
None
T3Q  A 301 ( 4.2A)
None
 1.45A 1p93A-3px2A:
undetectable		 1p93A-3px2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 ALA A  58
GLY A  60
SER A  81
ARG A 103
SER A 120
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 ( 4.7A)
SAH  A 263 (-3.3A)
 0.39A 1ve3A-3px2A:
19.7		 1ve3A-3px2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 ALA A  58
GLY A  60
SER A  81
ARG A 103
SER A 120
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 ( 4.7A)
SAH  A 263 (-3.3A)
 0.82A 1ve3B-3px2A:
19.7		 1ve3B-3px2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		3 / 3 HIS A 180
GLU A 191
HIS A 193
 None
 0.89A 3ba0A-3px2A:
undetectable		 3ba0A-3px2A:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		11 / 12 ALA A  58
GLY A  60
HIS A  64
LEU A  80
SER A  81
MET A  84
MET A 102
ARG A 103
PHE A 118
SER A 120
LEU A 124
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.3A)
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-4.5A)
SAH  A 263 ( 4.7A)
T3Q  A 301 ( 3.2A)
SAH  A 263 (-3.3A)
None
 0.41A 3bxoA-3px2A:
37.0		 3bxoA-3px2A:
59.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		3 / 3 TYR A  33
GLU A  79
ASP A 101
 SAH  A 263 (-4.6A)
SAH  A 263 (-2.7A)
SAH  A 263 (-3.5A)
 0.24A 3bxoA-3px2A:
37.0		 3bxoA-3px2A:
59.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		11 / 12 ALA A  58
GLY A  60
HIS A  64
LEU A  80
SER A  81
MET A  84
MET A 102
ARG A 103
MET A 117
PHE A 118
SER A 120
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.3A)
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-4.5A)
SAH  A 263 ( 4.7A)
None
T3Q  A 301 ( 3.2A)
SAH  A 263 (-3.3A)
 0.55A 3bxoB-3px2A:
36.9		 3bxoB-3px2A:
59.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		3 / 3 TYR A  33
GLU A  79
ASP A 101
 SAH  A 263 (-4.6A)
SAH  A 263 (-2.7A)
SAH  A 263 (-3.5A)
 0.34A 3bxoB-3px2A:
36.9		 3bxoB-3px2A:
59.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		7 / 12 ALA A  58
GLY A  60
LEU A  78
LEU A  80
SER A  81
MET A 102
SER A 120
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
None
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.56A 3g2oA-3px2A:
18.5		 3g2oA-3px2A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		7 / 12 ALA A  58
GLY A  60
LEU A  78
LEU A  80
ASP A 101
MET A 102
SER A 120
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
None
SAH  A 263 (-3.8A)
SAH  A 263 (-3.5A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.56A 3g2oB-3px2A:
19.9		 3g2oB-3px2A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 10 PHE A 137
GLU A 135
LEU A 130
LEU A 124
ILE A 121
 None
 1.29A 3kvrA-3px2A:
undetectable		 3kvrA-3px2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 10 PHE A 137
GLU A 135
LEU A 130
LEU A 124
ILE A 121
 None
 1.25A 3kvrB-3px2A:
undetectable		 3kvrB-3px2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		6 / 12 TYR A  14
ALA A  58
GLY A  60
SER A  81
MET A  84
ASP A 101
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
 0.95A 3ou6A-3px2A:
17.3		 3ou6A-3px2A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
ALA A  58
GLY A  60
SER A  81
MET A  84
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
 0.75A 3ou6B-3px2A:
17.4		 3ou6B-3px2A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
ALA A  58
SER A  81
MET A  84
ASP A 101
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.5A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
 0.92A 3ou6C-3px2A:
17.2		 3ou6C-3px2A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		6 / 12 TYR A  14
TYR A  22
ALA A  58
SER A  81
MET A  84
ASP A 101
 SAH  A 263 ( 3.9A)
SAH  A 263 (-4.6A)
SAH  A 263 (-3.5A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
 0.99A 3ou6D-3px2A:
17.1		 3ou6D-3px2A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		7 / 12 TYR A  14
TYR A  22
ALA A  58
GLY A  60
SER A  81
MET A  84
ASP A 101
 SAH  A 263 ( 3.9A)
SAH  A 263 (-4.6A)
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
 0.93A 3ou7A-3px2A:
17.1		 3ou7A-3px2A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  22
ALA A  58
GLY A  60
SER A  81
MET A  84
 SAH  A 263 (-4.6A)
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
 0.43A 3ou7B-3px2A:
17.3		 3ou7B-3px2A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
TYR A  22
ALA A  58
SER A  81
MET A  84
 SAH  A 263 ( 3.9A)
SAH  A 263 (-4.6A)
SAH  A 263 (-3.5A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
 0.75A 3ou7C-3px2A:
17.2		 3ou7C-3px2A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		7 / 12 TYR A  14
TYR A  22
ALA A  58
GLY A  60
SER A  81
MET A  84
ASP A 101
 SAH  A 263 ( 3.9A)
SAH  A 263 (-4.6A)
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
 0.95A 3ou7D-3px2A:
17.1		 3ou7D-3px2A:
28.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		11 / 12 TYR A  14
ALA A  58
GLY A  60
HIS A  64
LEU A  80
SER A  81
MET A  84
ASP A 101
MET A 102
PHE A 118
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.3A)
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
SAH  A 263 (-4.5A)
T3Q  A 301 ( 3.2A)
SAH  A 263 (-3.3A)
 0.15A 3pfgA-3px2A:
42.3		 3pfgA-3px2A:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		6 / 12 TYR A  14
GLY A  60
SER A  81
MET A  84
PHE A 118
HIS A 210
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
T3Q  A 301 ( 3.2A)
T3Q  A 301 ( 4.5A)
 1.46A 3pfgA-3px2A:
42.3		 3pfgA-3px2A:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		3 / 3 TYR A  22
TYR A  33
GLU A  79
 SAH  A 263 (-4.6A)
SAH  A 263 (-4.6A)
SAH  A 263 (-2.7A)
 0.07A 3pfgA-3px2A:
42.3		 3pfgA-3px2A:
99.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		4 / 6 GLY A  60
THR A  61
GLU A  79
ASP A  56
 SAH  A 263 (-3.3A)
None
SAH  A 263 (-2.7A)
None
 1.01A 3ps9A-3px2A:
9.7		 3ps9A-3px2A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 LEU A  43
HIS A  47
SER A 239
LEU A  40
HIS A  64
 None
None
None
None
SAH  A 263 (-4.3A)
 1.44A 3thrA-3px2A:
19.9
3thrB-3px2A:
20.7
3thrC-3px2A:
20.8
3thrD-3px2A:
20.2		 3thrA-3px2A:
25.75
3thrB-3px2A:
25.75
3thrC-3px2A:
25.75
3thrD-3px2A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		4 / 6 GLY A  60
GLU A  79
ASP A 101
ASP A  56
 SAH  A 263 (-3.3A)
SAH  A 263 (-2.7A)
SAH  A 263 (-3.5A)
None
 1.01A 3vywC-3px2A:
9.5		 3vywC-3px2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		3 / 3 ASP A  23
GLY A  62
TYR A  22
 None
None
SAH  A 263 (-4.6A)
 0.53A 3w9tC-3px2A:
undetectable		 3w9tC-3px2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		3 / 3 ASP A  23
GLY A  62
TYR A  22
 None
None
SAH  A 263 (-4.6A)
 0.54A 3w9tG-3px2A:
undetectable		 3w9tG-3px2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  14
GLY A  60
LEU A  80
SER A  81
ASP A 101
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-3.5A)
 0.58A 4krhA-3px2A:
17.4		 4krhA-3px2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		3 / 3 GLU A  20
THR A 204
HIS A 206
 None
 0.83A 4q15A-3px2A:
undetectable		 4q15A-3px2A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		3 / 3 GLU A  20
THR A 204
HIS A 206
 None
 0.80A 4q15B-3px2A:
undetectable		 4q15B-3px2A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 TYR A  22
GLY A  60
SER A  81
MET A  84
MET A 102
 SAH  A 263 (-4.6A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-4.5A)
 0.49A 4qtuD-3px2A:
18.9		 4qtuD-3px2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		6 / 12 ALA A 113
THR A 115
LEU A  54
PRO A  49
SER A  48
ALA A  51
 None
 1.48A 4ypmA-3px2A:
undetectable		 4ypmA-3px2A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		6 / 12 ALA A  58
GLY A  60
SER A  81
MET A  84
SER A 120
LEU A 124
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
None
 0.91A 5gwxA-3px2A:
22.7		 5gwxA-3px2A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		5 / 12 GLY A  60
SER A  81
MET A  84
ARG A 103
LEU A 124
 SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 ( 4.7A)
None
 0.70A 5gwxA-3px2A:
22.7		 5gwxA-3px2A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		6 / 12 GLY A  60
SER A  81
MET A  84
ASP A 101
ARG A 103
SER A 120
 SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
SAH  A 263 ( 4.7A)
SAH  A 263 (-3.3A)
 0.81A 5hikA-3px2A:
22.9		 5hikA-3px2A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		4 / 4 CYH A  59
LEU A  97
LEU A  65
ALA A  95
 None
 1.13A 5hpuA-3px2A:
undetectable
5hpuB-3px2A:
undetectable		 5hpuA-3px2A:
15.79
5hpuB-3px2A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		4 / 7 ALA A  58
GLY A  60
GLY A  62
GLU A  79
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
None
SAH  A 263 (-2.7A)
 0.68A 5ybbB-3px2A:
9.4		 5ybbB-3px2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		4 / 6 GLN A 219
GLU A 221
ALA A 223
GLN A 127
 None
 1.38A 6f6jC-3px2A:
undetectable
6f6jD-3px2A:
undetectable		 6f6jC-3px2A:
23.40
6f6jD-3px2A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3px2 N-METHYLTRANSFERASE
(Streptomyces
fradiae) 		4 / 7 TYR A  22
HIS A  26
TYR A  14
VAL A 192
 SAH  A 263 (-4.6A)
T3Q  A 301 (-4.1A)
SAH  A 263 ( 3.9A)
None
 1.00A 6g2pA-3px2A:
undetectable		 6g2pA-3px2A:
20.53