SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 10 LEU A  14
VAL A  13
ILE A  34
GLU A  94
VAL A 103
 None
 0.88A 1cqpA-3pxgA:
undetectable
1cqpB-3pxgA:
undetectable		 1cqpA-3pxgA:
18.68
1cqpB-3pxgA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3pxg ADAPTER PROTEIN MECA
1
(Bacillus
subtilis) 		5 / 12 ILE a 140
ASP a 135
PHE a 136
ILE a 203
ILE a 212
 None
 1.20A 1re7B-3pxga:
undetectable		 1re7B-3pxga:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 LEU A 131
GLU A 117
GLY A 118
ASN A 125
ALA A  84
 None
 1.06A 2br4B-3pxgA:
undetectable		 2br4B-3pxgA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 ALA A 314
PRO A 210
GLY A 208
ILE A 183
ALA A 216
 None
 0.91A 2plwA-3pxgA:
undetectable		 2plwA-3pxgA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		3 / 3 SER A 101
TYR A 102
HIS A 100
 None
 0.56A 2r2vD-3pxgA:
undetectable		 2r2vD-3pxgA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		4 / 7 LYS A 214
ILE A 217
GLY A 220
LEU A 179
 None
 0.90A 3bjwB-3pxgA:
undetectable		 3bjwB-3pxgA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 GLY A 116
GLY A 118
VAL A 123
LEU A 124
LEU A  90
 None
 0.97A 3cjtO-3pxgA:
undetectable		 3cjtO-3pxgA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		3 / 3 ARG A 235
VAL A 239
THR A 171
 None
 0.83A 3cyxA-3pxgA:
undetectable		 3cyxA-3pxgA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 10 VAL A 192
PHE A 277
ILE A 312
ALA A 216
VAL A 339
 None
 0.91A 3me6A-3pxgA:
undetectable		 3me6A-3pxgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		4 / 8 PHE A 277
ILE A 312
ALA A 216
VAL A 339
 None
 0.90A 3me6B-3pxgA:
undetectable		 3me6B-3pxgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 9 VAL A 192
PHE A 277
ILE A 312
ALA A 216
VAL A 339
 None
 0.97A 3me6C-3pxgA:
undetectable		 3me6C-3pxgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 9 VAL A 192
PHE A 277
ILE A 312
ALA A 216
VAL A 339
 None
 0.88A 3me6D-3pxgA:
undetectable		 3me6D-3pxgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		4 / 8 LEU A  50
LEU A  55
GLY A  56
VAL A  64
 None
 0.86A 4c9nA-3pxgA:
undetectable		 4c9nA-3pxgA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pxg ADAPTER PROTEIN MECA
1
(Bacillus
subtilis) 		5 / 11 ILE a 140
ASP a 135
PHE a 136
ILE a 203
ILE a 212
 None
 1.28A 4p68A-3pxga:
undetectable		 4p68A-3pxga:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		4 / 5 GLN A 352
LEU A 351
ASP A 180
ASP A 177
 None
 1.25A 4qtuD-3pxgA:
undetectable		 4qtuD-3pxgA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 9 ALA A 222
THR A 171
ALA A 174
VAL A 192
ALA A 218
 None
 1.17A 4qvnK-3pxgA:
undetectable
4qvnL-3pxgA:
undetectable		 4qvnK-3pxgA:
19.19
4qvnL-3pxgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 9 ALA A 222
THR A 171
ALA A 174
VAL A 192
ALA A 218
 None
 1.17A 4qvnY-3pxgA:
undetectable
4qvnZ-3pxgA:
undetectable		 4qvnY-3pxgA:
19.19
4qvnZ-3pxgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		4 / 7 GLU A 106
ARG A   9
THR A   7
GLY A 104
 None
 0.70A 4qwpB-3pxgA:
undetectable		 4qwpB-3pxgA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 3pxg ADAPTER PROTEIN MECA
1
NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		4 / 5 ASP A 428
VAL a 139
ASP a 138
GLY a 134
 None
 1.19A 4xp6A-3pxgA:
undetectable		 4xp6A-3pxgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
ADAPTER PROTEIN MECA
1
(Bacillus
subtilis;
Bacillus
subtilis) 		3 / 3 ASP A 428
SER a 156
TYR a 161
 None
 0.58A 5glmA-3pxgA:
undetectable		 5glmA-3pxgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 VAL A  64
GLU A  65
GLN A  76
GLY A  25
LEU A  22
 None
 1.49A 5m50B-3pxgA:
undetectable		 5m50B-3pxgA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 VAL A  64
ALA A 120
THR A 105
GLY A  56
LEU A  50
 None
 1.16A 5m54E-3pxgA:
undetectable		 5m54E-3pxgA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 ALA A  49
GLY A  44
GLU A  41
GLY A  42
GLU A  20
 None
 1.20A 5ul4A-3pxgA:
undetectable		 5ul4A-3pxgA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 10 VAL A 119
GLY A 118
GLY A 116
LEU A  35
THR A  31
 None
 0.95A 5vm8B-3pxgA:
undetectable		 5vm8B-3pxgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 ILE A 476
VAL A 479
TRP A 483
SER A 378
VAL A 375
 None
 1.30A 6ap6A-3pxgA:
undetectable		 6ap6A-3pxgA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB
(Bacillus
subtilis) 		5 / 12 ILE A 476
VAL A 479
TRP A 483
SER A 378
VAL A 375
 None
 1.31A 6ap6B-3pxgA:
undetectable		 6ap6B-3pxgA:
21.89