SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3pxh RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F
(Mus
musculus) 		4 / 8 VAL A 124
ARG A  77
ALA A  50
GLU A 102
 None
SO4  A   1 (-3.8A)
None
None
 1.09A 1dmiA-3pxhA:
undetectable
1dmiB-3pxhA:
undetectable		 1dmiA-3pxhA:
19.78
1dmiB-3pxhA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3pxh RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F
(Mus
musculus) 		5 / 11 SER A 132
ASN A 161
GLY A 159
THR A 136
GLY A 214
 None
 1.48A 1jr1A-3pxhA:
undetectable		 1jr1A-3pxhA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3pxh RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F
(Mus
musculus) 		5 / 12 LEU A  96
LEU A 122
ALA A 213
PHE A 134
LEU A 130
 None
 1.07A 2h42C-3pxhA:
undetectable		 2h42C-3pxhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3pxh RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F
(Mus
musculus) 		5 / 12 GLY A  44
ALA A  50
ARG A  92
VAL A  98
LEU A  96
 None
None
None
SO4  A   2 (-4.0A)
None
 1.01A 2yqzA-3pxhA:
undetectable		 2yqzA-3pxhA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3pxh RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F
(Mus
musculus) 		5 / 12 GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
 None
 1.26A 4ffwA-3pxhA:
undetectable		 4ffwA-3pxhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3pxh RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F
(Mus
musculus) 		5 / 12 GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
 None
 1.26A 4ffwB-3pxhA:
undetectable		 4ffwB-3pxhA:
13.97