SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pxj TYROSINE-PROTEIN
PHOSPHATASE LAR
(Drosophila
melanogaster) 		4 / 7 TRP A  69
VAL A  85
TYR A  56
ILE A  67
 None
 1.22A 2xz5B-3pxjA:
undetectable
2xz5E-3pxjA:
undetectable		 2xz5B-3pxjA:
21.76
2xz5E-3pxjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pxj TYROSINE-PROTEIN
PHOSPHATASE LAR
(Drosophila
melanogaster) 		4 / 8 ILE A  67
TRP A  69
VAL A  85
TYR A  56
 None
 1.25A 2xz5A-3pxjA:
undetectable
2xz5C-3pxjA:
undetectable		 2xz5A-3pxjA:
21.76
2xz5C-3pxjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pxj TYROSINE-PROTEIN
PHOSPHATASE LAR
(Drosophila
melanogaster) 		4 / 8 ILE A  67
TRP A  69
VAL A  85
TYR A  56
 None
 1.27A 2xz5C-3pxjA:
undetectable
2xz5D-3pxjA:
undetectable		 2xz5C-3pxjA:
21.76
2xz5D-3pxjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pxj TYROSINE-PROTEIN
PHOSPHATASE LAR
(Drosophila
melanogaster) 		4 / 7 ILE A  67
TRP A  69
VAL A  85
TYR A  56
 None
 1.26A 2xz5D-3pxjA:
undetectable
2xz5E-3pxjA:
undetectable		 2xz5D-3pxjA:
21.76
2xz5E-3pxjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3pxj TYROSINE-PROTEIN
PHOSPHATASE LAR
(Drosophila
melanogaster) 		5 / 10 THR A 156
GLY A 154
VAL A 153
GLU A 152
ASN A 198
 None
 1.43A 3uayA-3pxjA:
undetectable		 3uayA-3pxjA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3pxj TYROSINE-PROTEIN
PHOSPHATASE LAR
(Drosophila
melanogaster) 		4 / 8 THR A  84
TYR A 109
TRP A  69
ARG A  96
 None
 1.45A 3wipB-3pxjA:
undetectable
3wipC-3pxjA:
undetectable		 3wipB-3pxjA:
20.68
3wipC-3pxjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3pxj TYROSINE-PROTEIN
PHOSPHATASE LAR
(Drosophila
melanogaster) 		5 / 11 VAL A 210
PHE A 139
GLY A  51
GLY A  50
ILE A  97
 None
 1.41A 4zvmA-3pxjA:
undetectable
4zvmB-3pxjA:
undetectable		 4zvmA-3pxjA:
22.40
4zvmB-3pxjA:
22.40