SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		4 / 6 GLY A 252
SER A 275
LEU A 227
ILE A 144
 None
 0.94A 1yajF-3pxnA:
undetectable		 1yajF-3pxnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		4 / 7 MET A  97
LEU A 227
GLY A  87
THR A 310
 None
 1.09A 2bdmA-3pxnA:
undetectable		 2bdmA-3pxnA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		4 / 7 VAL A  72
TYR A 290
CYH A  81
ILE A  68
 None
 1.16A 2xz5B-3pxnA:
undetectable
2xz5E-3pxnA:
undetectable		 2xz5B-3pxnA:
17.66
2xz5E-3pxnA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 12 SER A 284
SER A 140
CYH A 169
LEU A 227
LEU A 251
 None
 1.39A 2zlcA-3pxnA:
undetectable		 2zlcA-3pxnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		4 / 5 SER A   7
LEU A  75
GLY A  78
CYH A  81
 None
 1.12A 3aiaA-3pxnA:
undetectable
3aiaB-3pxnA:
undetectable		 3aiaA-3pxnA:
21.11
3aiaB-3pxnA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 12 ILE A 144
LEU A 227
ASN A 223
VAL A 225
PRO A 149
 None
 1.28A 3dcjA-3pxnA:
undetectable
3dcjB-3pxnA:
undetectable		 3dcjA-3pxnA:
20.99
3dcjB-3pxnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		3 / 3 TYR A  64
ASP A  73
ASP A 119
 None
 0.58A 3r24A-3pxnA:
undetectable		 3r24A-3pxnA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 9 PHE A 293
VAL A 225
PHE A 313
ILE A 256
GLY A 252
 None
 1.31A 3t3rC-3pxnA:
undetectable		 3t3rC-3pxnA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 10 PHE A 293
VAL A 225
PHE A 313
ILE A 256
GLY A 252
 None
 1.34A 3t3rD-3pxnA:
undetectable		 3t3rD-3pxnA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 11 GLY A 232
GLN A  88
GLU A 306
THR A 307
THR A 310
 None
 1.47A 3wg7A-3pxnA:
undetectable
3wg7B-3pxnA:
undetectable
3wg7T-3pxnA:
undetectable		 3wg7A-3pxnA:
20.31
3wg7B-3pxnA:
22.22
3wg7T-3pxnA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 11 SER A 275
PHE A 141
LEU A 281
ALA A  85
ARG A 191
 None
 1.29A 4dx7A-3pxnA:
0.8		 4dx7A-3pxnA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 12 GLY A 252
SER A 255
ILE A 249
ASN A 248
GLY A 229
 None
 0.99A 4obwA-3pxnA:
undetectable		 4obwA-3pxnA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 12 LEU A  67
GLY A  98
LEU A 113
VAL A 209
THR A 210
 None
 1.21A 4wnwA-3pxnA:
undetectable		 4wnwA-3pxnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		4 / 8 GLU A 143
LEU A 152
ARG A 192
LEU A 184
 None
 1.15A 5dxeA-3pxnA:
undetectable		 5dxeA-3pxnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		4 / 8 GLY A 252
THR A 278
LEU A 254
ASN A 257
 None
 1.05A 5hwaA-3pxnA:
undetectable		 5hwaA-3pxnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 12 LEU A 113
ASP A 119
GLY A 118
LEU A 174
ALA A 139
 None
 1.27A 5kc4E-3pxnA:
undetectable		 5kc4E-3pxnA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 11 GLY A  92
GLY A 229
GLN A  88
THR A 307
THR A 310
 ADP  A 401 (-3.2A)
None
None
None
None
 1.23A 5x1bG-3pxnA:
undetectable
5x1bN-3pxnA:
0.0
5x1bO-3pxnA:
undetectable		 5x1bG-3pxnA:
15.44
5x1bN-3pxnA:
20.31
5x1bO-3pxnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		5 / 11 ILE A 256
LEU A 253
LEU A 294
ILE A 224
MET A  97
 None
 1.48A 6fgcA-3pxnA:
undetectable		 6fgcA-3pxnA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 3pxn KINESIN-LIKE PROTEIN
NOD
(Drosophila
melanogaster) 		4 / 5 THR A 286
THR A 210
HIS A 212
GLY A  78
 None
 1.13A 6gbnC-3pxnA:
undetectable		 6gbnC-3pxnA:
20.09