SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 TYR A 192
SER A 289
TRP A 286
ILE A 121
ALA A 284
 None
 1.02A 2a58A-3pxpA:
undetectable
2a58E-3pxpA:
undetectable		 2a58A-3pxpA:
19.01
2a58E-3pxpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 121
ALA A 284
TYR A 192
SER A 289
TRP A 286
 None
 1.05A 2a58A-3pxpA:
undetectable
2a58B-3pxpA:
undetectable		 2a58A-3pxpA:
19.01
2a58B-3pxpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 121
ALA A 284
TYR A 192
SER A 289
TRP A 286
 None
 1.03A 2a58B-3pxpA:
undetectable
2a58C-3pxpA:
undetectable		 2a58B-3pxpA:
19.01
2a58C-3pxpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 11 ILE A 121
ALA A 284
TYR A 192
SER A 289
TRP A 286
 None
 1.02A 2a58C-3pxpA:
undetectable
2a58D-3pxpA:
undetectable		 2a58C-3pxpA:
19.01
2a58D-3pxpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 ILE A 121
ALA A 284
TYR A 192
SER A 289
TRP A 286
 None
 1.05A 2a58D-3pxpA:
undetectable
2a58E-3pxpA:
undetectable		 2a58D-3pxpA:
19.01
2a58E-3pxpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 LEU A  36
ILE A  41
VAL A  10
GLY A   7
LEU A  60
 None
 1.20A 2bxeB-3pxpA:
undetectable		 2bxeB-3pxpA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 5 ILE A 281
TYR A 148
ARG A 152
THR A 140
 None
 1.36A 3abkN-3pxpA:
undetectable
3abkW-3pxpA:
undetectable		 3abkN-3pxpA:
19.44
3abkW-3pxpA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		5 / 12 PHE A 161
VAL A 164
PHE A 269
LEU A 272
TYR A 239
 MYR  A 301 (-4.6A)
None
None
None
None
 1.44A 3apvB-3pxpA:
undetectable		 3apvB-3pxpA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 8 TYR A 258
TYR A 239
PHE A 130
ILE A 126
 MYR  A 301 (-4.5A)
None
None
None
 1.02A 3jz0B-3pxpA:
undetectable		 3jz0B-3pxpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 8 MET A 151
PHE A 155
ALA A 173
THR A 220
 None
 0.97A 3l4dD-3pxpA:
undetectable		 3l4dD-3pxpA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 8 PHE A 155
PHE A 206
ALA A 213
THR A  67
 None
 0.92A 3t3sD-3pxpA:
undetectable		 3t3sD-3pxpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 5 TYR A 239
PHE A 269
PRO A 110
LEU A 268
 None
 1.45A 3tgvC-3pxpA:
undetectable		 3tgvC-3pxpA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN
(Chloroflexus
aurantiacus) 		4 / 7 ASN A 176
ALA A 173
GLU A 216
LEU A 179
 MYR  A 301 (-3.1A)
None
None
None
 1.02A 6ci6A-3pxpA:
undetectable		 6ci6A-3pxpA:
13.89