SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pxu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 11 LEU A  58
VAL A  35
TYR A   6
PRO A  12
LEU A  13
 None
None
COD  A 201 (-4.7A)
None
None
 1.23A 1klmA-3pxuA:
undetectable		 1klmA-3pxuA:
14.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Burkholderia
pseudomallei) 		3 / 3 SER A 127
GLY A 128
THR A 129
 SO4  A 205 (-3.0A)
SO4  A 205 (-3.8A)
SO4  A 205 (-4.3A)
 0.05A 3k9wA-3pxuA:
30.8		 3k9wA-3pxuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A  49
ASP A  11
PRO A  12
 None
 0.80A 6berA-3pxuA:
undetectable		 6berA-3pxuA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 4 LEU A 153
ASP A  11
PRO A  12
ARG A 132
 None
None
None
SO4  A 205 ( 4.9A)
 1.31A 6fgdA-3pxuA:
2.9		 6fgdA-3pxuA:
17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 5 GLY A   8
THR A   9
HIS A  17
SER A 127
 COD  A 201 (-3.1A)
COD  A 201 (-3.6A)
COD  A 201 (-4.3A)
SO4  A 205 (-3.0A)
 0.74A 6jmjA-3pxuA:
25.4		 6jmjA-3pxuA:
52.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Burkholderia
pseudomallei) 		5 / 7 GLY A   8
THR A   9
PHE A  10
HIS A  17
SER A 127
 COD  A 201 (-3.1A)
COD  A 201 (-3.6A)
COD  A 201 (-4.5A)
COD  A 201 (-4.3A)
SO4  A 205 (-3.0A)
 0.75A 6jnhA-3pxuA:
25.6		 6jnhA-3pxuA:
52.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE
(Burkholderia
pseudomallei) 		4 / 6 GLY A   8
THR A   9
HIS A  17
SER A 127
 COD  A 201 (-3.1A)
COD  A 201 (-3.6A)
COD  A 201 (-4.3A)
SO4  A 205 (-3.0A)
 0.79A 6jogA-3pxuA:
25.4		 6jogA-3pxuA:
52.98