SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pxv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3pxv NITROREDUCTASE
(Desulfitobacteri
um
hafniense) 		4 / 7 SER A 142
GLU A  64
GLU A  60
GLU A 148
 None
 1.18A 1knyA-3pxvA:
undetectable
1knyB-3pxvA:
undetectable		 1knyA-3pxvA:
21.35
1knyB-3pxvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3pxv NITROREDUCTASE
(Desulfitobacteri
um
hafniense) 		4 / 8 GLU A 148
SER A 142
GLU A  64
GLU A  60
 None
 1.18A 1knyA-3pxvA:
undetectable
1knyB-3pxvA:
undetectable		 1knyA-3pxvA:
21.35
1knyB-3pxvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 3pxv NITROREDUCTASE
(Desulfitobacteri
um
hafniense) 		4 / 6 PHE A 140
ALA A 139
THR A 136
LEU A  57
 None
 0.97A 3t3zA-3pxvA:
undetectable		 3t3zA-3pxvA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 3pxv NITROREDUCTASE
(Desulfitobacteri
um
hafniense) 		4 / 6 PHE A 140
ALA A 139
THR A 136
LEU A  57
 None
 0.98A 3t3zB-3pxvA:
undetectable		 3t3zB-3pxvA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 3pxv NITROREDUCTASE
(Desulfitobacteri
um
hafniense) 		4 / 5 PHE A 140
ALA A 139
THR A 136
LEU A  57
 None
 1.01A 3t3zC-3pxvA:
undetectable		 3t3zC-3pxvA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3pxv NITROREDUCTASE
(Desulfitobacteri
um
hafniense) 		5 / 9 THR A 124
LEU A 126
ILE A  31
PRO A  23
LEU A  27
 None
 1.34A 5g48B-3pxvA:
undetectable		 5g48B-3pxvA:
20.90