SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 SER A 150
VAL A 151
GLY A 153
TYR A 174
MET A 217
 NAD  A 284 (-3.7A)
None
None
NAD  A 284 (-4.5A)
None
 1.20A 1a27A-3pxxA:
25.5		 1a27A-3pxxA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 6 HIS A 203
ILE A 202
ALA A 250
VAL A 257
 None
 1.05A 1hk1A-3pxxA:
undetectable		 1hk1A-3pxxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 11 SER A 150
VAL A 151
GLY A 153
TYR A 174
MET A 217
 NAD  A 284 (-3.7A)
None
None
NAD  A 284 (-4.5A)
None
 1.04A 1iolA-3pxxA:
24.6		 1iolA-3pxxA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 10 THR A 131
LEU A 139
VAL A  99
THR A 147
VAL A 128
 None
 1.38A 1o76A-3pxxA:
undetectable		 1o76A-3pxxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		7 / 11 GLY A  13
ALA A  15
ASP A  37
ARG A  16
VAL A  76
ALA A 103
VAL A 123
 NAD  A 284 (-3.4A)
NAD  A 284 ( 4.2A)
NAD  A 284 (-2.8A)
NAD  A 284 (-3.8A)
NAD  A 284 (-3.5A)
NAD  A 284 (-3.6A)
NAD  A 284 (-4.0A)
 1.29A 1uayA-3pxxA:
27.4		 1uayA-3pxxA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		7 / 11 GLY A  13
ALA A  15
ASP A  37
ASP A  75
VAL A  76
ALA A 103
VAL A 123
 NAD  A 284 (-3.4A)
NAD  A 284 ( 4.2A)
NAD  A 284 (-2.8A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
NAD  A 284 (-3.6A)
NAD  A 284 (-4.0A)
 0.28A 1uayA-3pxxA:
27.4		 1uayA-3pxxA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		7 / 10 GLY A  13
ALA A  15
ASP A  37
ASP A  75
VAL A  76
ALA A 103
VAL A 123
 NAD  A 284 (-3.4A)
NAD  A 284 ( 4.2A)
NAD  A 284 (-2.8A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
NAD  A 284 (-3.6A)
NAD  A 284 (-4.0A)
 0.26A 1uayB-3pxxA:
27.4		 1uayB-3pxxA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 5 PRO A 204
VAL A 275
VAL A 248
ILE A 253
 NAD  A 284 (-4.0A)
None
None
None
 1.10A 1z2bC-3pxxA:
6.5		 1z2bC-3pxxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 GLY A  13
ASP A  37
ASP A  75
ASN A 102
ALA A 103
 NAD  A 284 (-3.4A)
NAD  A 284 (-2.8A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.4A)
NAD  A 284 (-3.6A)
 0.94A 2bm9E-3pxxA:
4.7		 2bm9E-3pxxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 6 VAL A  82
SER A  83
ARG A  79
HIS A 133
 None
 1.27A 2f8dA-3pxxA:
undetectable		 2f8dA-3pxxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		6 / 12 ALA A  15
GLY A  14
ILE A  38
ASP A  75
VAL A  76
ARG A  77
 NAD  A 284 ( 4.2A)
None
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
None
 1.47A 2qe6A-3pxxA:
6.0		 2qe6A-3pxxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		6 / 12 ALA A  15
GLY A  14
ILE A  38
ASP A  75
VAL A  76
VAL A 100
 NAD  A 284 ( 4.2A)
None
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
None
 1.47A 2qe6A-3pxxA:
6.0		 2qe6A-3pxxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		6 / 12 ALA A  50
GLY A  13
ILE A  38
ASP A  75
VAL A  76
ARG A  77
 NAD  A 284 (-3.4A)
NAD  A 284 (-3.4A)
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
None
 1.11A 2qe6A-3pxxA:
6.0		 2qe6A-3pxxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		6 / 12 ALA A  15
GLY A  14
ILE A  38
ASP A  75
VAL A  76
VAL A 100
 NAD  A 284 ( 4.2A)
None
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
None
 1.39A 2qe6B-3pxxA:
5.7		 2qe6B-3pxxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 ALA A  50
ILE A  38
ASP A  75
VAL A  76
ARG A  77
 NAD  A 284 (-3.4A)
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
None
 0.84A 2qe6B-3pxxA:
5.7		 2qe6B-3pxxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 GLY A  14
ILE A  38
ASP A  75
VAL A  76
ARG A  77
 None
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
None
 0.79A 2qe6B-3pxxA:
5.7		 2qe6B-3pxxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 10 ASP A  37
ILE A  38
ALA A  15
ASP A  75
VAL A  76
 NAD  A 284 (-2.8A)
NAD  A 284 (-3.6A)
NAD  A 284 ( 4.2A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
 0.95A 3ay0A-3pxxA:
6.3		 3ay0A-3pxxA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 10 ASP A  37
ILE A  38
ALA A  50
ASP A  75
VAL A  76
 NAD  A 284 (-2.8A)
NAD  A 284 (-3.6A)
NAD  A 284 (-3.4A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
 1.32A 3ay0A-3pxxA:
6.3		 3ay0A-3pxxA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 10 GLY A  14
ASP A  37
ILE A  38
ASP A  75
VAL A  76
 None
NAD  A 284 (-2.8A)
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
 1.01A 3ay0B-3pxxA:
6.2		 3ay0B-3pxxA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 5 PRO A 107
THR A 131
VAL A 128
GLY A 127
 None
 1.11A 3elzA-3pxxA:
undetectable		 3elzA-3pxxA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		3 / 3 ARG A  53
GLU A  73
ASP A  75
 None
None
NAD  A 284 (-3.7A)
 0.91A 3g2oA-3pxxA:
2.1		 3g2oA-3pxxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 9 GLY A 127
ASP A  75
GLY A  13
LEU A  86
VAL A  82
 None
NAD  A 284 (-3.7A)
NAD  A 284 (-3.4A)
None
None
 0.89A 3u7sB-3pxxA:
undetectable		 3u7sB-3pxxA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 5 ASP A  75
GLY A 127
VAL A 123
THR A  12
 NAD  A 284 (-3.7A)
None
NAD  A 284 (-4.0A)
None
 1.09A 3vqrB-3pxxA:
4.1		 3vqrB-3pxxA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 7 ASN A  45
GLY A 171
TYR A 174
SER A 175
 None
None
NAD  A 284 (-4.5A)
None
 0.91A 4cp3A-3pxxA:
undetectable
4cp3B-3pxxA:
undetectable		 4cp3A-3pxxA:
19.86
4cp3B-3pxxA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 5 GLY A  14
THR A 131
VAL A  74
ASP A  37
 None
None
None
NAD  A 284 (-2.8A)
 1.15A 4eohA-3pxxA:
6.5		 4eohA-3pxxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 ILE A 145
VAL A  99
ALA A 134
LEU A 136
LEU A 139
 None
 1.15A 4m11C-3pxxA:
undetectable		 4m11C-3pxxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 6 LEU A 180
LEU A 186
THR A 147
VAL A 128
 None
 0.88A 4udaA-3pxxA:
undetectable		 4udaA-3pxxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 5 TYR A  47
GLY A 104
TYR A 174
GLY A 173
 None
NAD  A 284 (-3.7A)
NAD  A 284 (-4.5A)
None
 0.78A 5ayfA-3pxxA:
undetectable		 5ayfA-3pxxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		4 / 7 LEU A 108
GLY A 171
ALA A 172
SER A 175
 None
 0.80A 5f1aB-3pxxA:
undetectable		 5f1aB-3pxxA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 9 ASP A 124
ALA A 157
PHE A 117
GLY A 171
GLY A 153
 None
 1.27A 6awoA-3pxxA:
undetectable		 6awoA-3pxxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 9 ASP A 124
ALA A 157
PHE A 117
GLY A 171
GLY A 153
 None
 1.28A 6awqA-3pxxA:
undetectable		 6awqA-3pxxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3pxx CARVEOL
DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 GLY A  66
VAL A  11
ARG A  67
ILE A  33
ASP A  32
 None
 1.22A 6bxmA-3pxxA:
2.5		 6bxmA-3pxxA:
23.45