SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3py9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3py9 PROTEIN KINASE
(Staphylococcus
aureus) 		4 / 6 THR A 216
ASP A 241
ASN A 244
ASP A 245
 None
 1.09A 2okcA-3py9A:
undetectable		 2okcA-3py9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3py9 PROTEIN KINASE
(Staphylococcus
aureus) 		5 / 10 ILE A  13
SER A  16
LYS A  15
GLY A  14
LYS A  49
 None
 1.15A 3ik6B-3py9A:
undetectable
3ik6E-3py9A:
undetectable		 3ik6B-3py9A:
25.08
3ik6E-3py9A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3py9 PROTEIN KINASE
(Staphylococcus
aureus) 		5 / 10 LYS A  49
ILE A  13
SER A  16
LYS A  15
GLY A  14
 None
 1.19A 3ik6B-3py9A:
undetectable
3ik6E-3py9A:
undetectable		 3ik6B-3py9A:
25.08
3ik6E-3py9A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3py9 PROTEIN KINASE
(Staphylococcus
aureus) 		5 / 11 ILE A  13
SER A  16
LYS A  15
GLY A  14
LYS A  49
 None
 1.17A 3iluB-3py9A:
undetectable
3iluE-3py9A:
undetectable		 3iluB-3py9A:
25.08
3iluE-3py9A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3py9 PROTEIN KINASE
(Staphylococcus
aureus) 		4 / 5 ILE A  13
SER A  16
LYS A  15
GLY A  14
 None
 1.01A 3tkdB-3py9A:
undetectable		 3tkdB-3py9A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3py9 PROTEIN KINASE
(Staphylococcus
aureus) 		4 / 5 ILE A  13
SER A  16
LYS A  15
GLY A  14
 None
 1.02A 3tkdA-3py9A:
undetectable		 3tkdA-3py9A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3py9 PROTEIN KINASE
(Staphylococcus
aureus) 		3 / 3 GLU A 103
TYR A 136
SER A 119
 None
 0.96A 4at0A-3py9A:
undetectable		 4at0A-3py9A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3py9 PROTEIN KINASE
(Staphylococcus
aureus) 		4 / 7 LEU A  97
ASN A 132
ILE A 133
ASP A  99
 None
EU  A 305 (-3.6A)
None
EU  A 305 (-2.7A)
 0.63A 4rmjA-3py9A:
undetectable		 4rmjA-3py9A:
21.01