SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pyc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3pyc E3 UBIQUITIN-PROTEIN
LIGASE SMURF1
(Homo
sapiens) 		5 / 12 ILE A 105
LEU A 100
VAL A  98
LEU A  17
ALA A  38
 None
 1.00A 3ozuA-3pycA:
undetectable		 3ozuA-3pycA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3pyc E3 UBIQUITIN-PROTEIN
LIGASE SMURF1
(Homo
sapiens) 		4 / 7 VAL A  41
ILE A  40
LEU A 108
LEU A 137
 None
 0.83A 4l1wA-3pycA:
undetectable		 4l1wA-3pycA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3pyc E3 UBIQUITIN-PROTEIN
LIGASE SMURF1
(Homo
sapiens) 		5 / 12 ILE A 133
LEU A 108
SER A  75
ILE A  76
LEU A  17
 None
 1.16A 4qi9B-3pycA:
undetectable		 4qi9B-3pycA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3pyc E3 UBIQUITIN-PROTEIN
LIGASE SMURF1
(Homo
sapiens) 		4 / 6 THR A  77
ARG A  99
ASP A  74
GLY A  44
 None
 1.15A 5mraA-3pycA:
undetectable
5mraB-3pycA:
undetectable		 5mraA-3pycA:
22.54
5mraB-3pycA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 3pyc E3 UBIQUITIN-PROTEIN
LIGASE SMURF1
(Homo
sapiens) 		5 / 12 VAL A  80
TRP A  62
LEU A  17
ALA A  22
LEU A 116
 None
 1.03A 5og9B-3pycA:
undetectable		 5og9B-3pycA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 3pyc E3 UBIQUITIN-PROTEIN
LIGASE SMURF1
(Homo
sapiens) 		5 / 12 VAL A  98
ILE A  40
ILE A 133
LEU A  68
LEU A 137
 None
 0.95A 6ajiA-3pycA:
undetectable		 6ajiA-3pycA:
9.76