SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 314
TYR A 318
ASN A 153
TYR A 312
 NAD  A 333 (-3.7A)
NAD  A 333 (-3.6A)
None
None
 0.95A 1dssG-3pymA:
52.0		 1dssG-3pymA:
65.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		7 / 7 SER A 149
THR A 151
ASN A 153
CYH A 154
TYR A 312
ASN A 314
TYR A 318
 None
None
None
None
None
NAD  A 333 (-3.7A)
NAD  A 333 (-3.6A)
 0.16A 1dssG-3pymA:
52.0		 1dssG-3pymA:
65.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 314
TYR A 318
ASN A 153
TYR A 312
 NAD  A 333 (-3.7A)
NAD  A 333 (-3.6A)
None
None
 0.94A 1dssR-3pymA:
51.8		 1dssR-3pymA:
65.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		8 / 8 SER A 149
THR A 151
ASN A 153
CYH A 154
HIS A 177
TYR A 312
ASN A 314
TYR A 318
 None
None
None
None
None
None
NAD  A 333 (-3.7A)
NAD  A 333 (-3.6A)
 0.33A 1dssR-3pymA:
51.8		 1dssR-3pymA:
65.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  77
ASP A  33
GLY A   8
ALA A  93
PHE A  35
 None
NAD  A 333 (-2.9A)
NAD  A 333 (-3.4A)
None
NAD  A 333 ( 4.7A)
 1.34A 1nw3A-3pymA:
undetectable		 1nw3A-3pymA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 293
SER A 291
LEU A 243
VAL A 245
ALA A 165
 None
 1.23A 1q23A-3pymA:
undetectable
1q23B-3pymA:
undetectable		 1q23A-3pymA:
18.45
1q23B-3pymA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 215
GLY A 210
LEU A 243
THR A 175
THR A 152
 None
 1.09A 2egvA-3pymA:
3.3		 2egvA-3pymA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 314
TYR A 318
ASN A 153
TYR A 312
 NAD  A 333 (-3.7A)
NAD  A 333 (-3.6A)
None
None
 0.97A 3dmtC-3pymA:
48.8		 3dmtC-3pymA:
51.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		8 / 8 SER A 149
THR A 151
ASN A 153
CYH A 154
HIS A 177
TYR A 312
ASN A 314
TYR A 318
 None
None
None
None
None
None
NAD  A 333 (-3.7A)
NAD  A 333 (-3.6A)
 0.29A 3dmtC-3pymA:
48.8		 3dmtC-3pymA:
51.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 9 VAL A   4
ALA A 114
ILE A 144
PHE A 129
ILE A  94
 None
 1.32A 3hbbB-3pymA:
undetectable		 3hbbB-3pymA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 162
LEU A 158
ALA A 263
ALA A 264
 None
 0.82A 3r9tB-3pymA:
undetectable		 3r9tB-3pymA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 6 THR A  97
ASN A   7
ASP A  33
ILE A  36
 NAD  A 333 (-4.2A)
NAD  A 333 (-3.6A)
NAD  A 333 (-2.9A)
None
 1.26A 3w9tB-3pymA:
undetectable		 3w9tB-3pymA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 159
GLY A 171
LEU A 243
VAL A 245
 None
 0.95A 4dubB-3pymA:
undetectable		 4dubB-3pymA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 260
ALA A 263
PHE A 293
SER A 291
GLY A 273
 None
 1.38A 4mm4A-3pymA:
undetectable		 4mm4A-3pymA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  72
HIS A 109
ILE A  92
VAL A   2
 None
 1.01A 4zj8A-3pymA:
7.3		 4zj8A-3pymA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 152
ALA A 148
ASN A 153
 None
 0.57A 5ersA-3pymA:
2.2		 5ersA-3pymA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  43
ILE A  36
TYR A  40
GLY A  10
 None
None
None
NAD  A 333 (-2.9A)
 0.92A 5esfA-3pymA:
undetectable		 5esfA-3pymA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 231
VAL A 176
ALA A 230
THR A 151
 None
 1.04A 5t7bA-3pymA:
3.7		 5t7bA-3pymA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  13
ILE A  12
ASP A  48
HIS A  51
 None
NAD  A 333 (-4.0A)
None
None
 1.00A 6ag0C-3pymA:
undetectable		 6ag0C-3pymA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  18
HIS A  51
ARG A  11
 None
 1.16A 6dwdD-3pymA:
undetectable		 6dwdD-3pymA:
22.10