SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		4 / 4 LEU A 311
VAL A 304
ILE A 312
TRP A 403
 None
 1.36A 1s9qB-3pyzA:
undetectable		 1s9qB-3pyzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		4 / 7 TYR A  89
HIS A 105
LEU A 134
TYR A  81
 None
 1.17A 1tuvA-3pyzA:
undetectable		 1tuvA-3pyzA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 12 LEU A  32
GLY A 190
GLY A 151
LEU A 149
GLY A 148
 None
 1.01A 1y4lA-3pyzA:
undetectable		 1y4lA-3pyzA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 11 LEU A  42
LEU A  44
VAL A 159
ILE A 112
LEU A 121
 None
 1.26A 2q6hA-3pyzA:
1.6		 2q6hA-3pyzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 11 ALA A 273
ILE A  70
ALA A  69
ALA A 296
VAL A 265
 None
 1.12A 2qhfA-3pyzA:
undetectable		 2qhfA-3pyzA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 9 VAL A 200
VAL A 191
GLY A 190
ILE A 169
ALA A  55
 None
 0.88A 2z0yB-3pyzA:
2.3		 2z0yB-3pyzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 12 LEU A 129
ALA A 131
LEU A 145
LEU A  32
ALA A  39
 None
 1.14A 3dfrA-3pyzA:
undetectable		 3dfrA-3pyzA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 9 PHE A 192
ILE A 166
ALA A 165
THR A 272
ALA A 275
 None
 1.32A 3mdtA-3pyzA:
undetectable		 3mdtA-3pyzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		4 / 7 PRO A  84
LEU A  17
GLU A  91
PHE A 422
 ANP  A 601 (-4.5A)
None
None
ANP  A 601 (-4.4A)
 1.00A 3tehB-3pyzA:
undetectable		 3tehB-3pyzA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		4 / 5 TYR A 123
THR A  62
LEU A 298
THR A  90
 None
ANP  A 601 (-2.8A)
None
None
 1.44A 4mbsB-3pyzA:
undetectable		 4mbsB-3pyzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 12 SER A 183
GLU A 182
ASP A 180
ILE A 169
ILE A 166
 None
 1.24A 4uroA-3pyzA:
undetectable		 4uroA-3pyzA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 12 SER A 183
GLU A 182
ASP A 180
ILE A 169
ILE A 166
 None
 1.25A 4uroB-3pyzA:
undetectable		 4uroB-3pyzA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 10 PHE A 192
ILE A 166
ALA A 165
THR A 272
ALA A 275
 None
 1.23A 6h1lA-3pyzA:
undetectable		 6h1lA-3pyzA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Yersinia
pestis) 		5 / 11 PHE A 192
ILE A 166
ALA A 165
THR A 272
ALA A 275
 None
 1.25A 6h1lB-3pyzA:
undetectable		 6h1lB-3pyzA:
23.39