SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 TYR B  26
THR B 291
VAL B 239
ASP B 238
GLY B  53
 None
None
None
ZN  B   1 ( 2.1A)
None
 1.30A 1xvaA-3pz2B:
undetectable		 1xvaA-3pz2B:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 TYR B  26
THR B 291
VAL B 239
ASP B 238
TYR B  30
 None
None
None
ZN  B   1 ( 2.1A)
None
 1.36A 1xvaA-3pz2B:
undetectable		 1xvaA-3pz2B:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		3 / 3 VAL B 239
TRP B 243
TRP B 244
 None
GRG  B 334 ( 4.8A)
GRG  B 334 ( 3.8A)
 1.45A 2xdcC-3pz2B:
undetectable
2xdcD-3pz2B:
undetectable		 2xdcC-3pz2B:
4.01
2xdcD-3pz2B:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 LEU B 298
VAL B  56
ILE B  27
GLY B 276
ILE B 295
 None
 0.86A 3bvbA-3pz2B:
undetectable		 3bvbA-3pz2B:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 9 LEU B 298
VAL B  56
ILE B  27
GLY B 276
ILE B 295
 None
 1.00A 3el0B-3pz2B:
undetectable		 3el0B-3pz2B:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 LEU B 298
VAL B  56
ILE B  27
GLY B 276
ILE B 295
 None
 0.98A 3em6B-3pz2B:
undetectable		 3em6B-3pz2B:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 11 GLU B 140
LEU B  96
ARG B 144
GLY B  84
HIS B  80
 None
 1.35A 3hm1B-3pz2B:
undetectable		 3hm1B-3pz2B:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 LEU B 298
VAL B  56
ILE B  27
GLY B 276
ILE B 295
 None
 0.89A 3nu5A-3pz2B:
undetectable		 3nu5A-3pz2B:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 GLY B 294
ALA B 296
PHE B 289
ASP B 287
VAL B 239
 None
None
3PZ  B 333 (-4.0A)
3PZ  B 333 (-3.6A)
None
 1.23A 3nvkF-3pz2B:
undetectable
3nvkJ-3pz2B:
undetectable		 3nvkF-3pz2B:
22.25
3nvkJ-3pz2B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 LEU B 298
LEU B 263
ARG B 264
GLY B 228
LEU B 268
 None
 1.26A 3okxB-3pz2B:
undetectable		 3okxB-3pz2B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 4 LEU B 292
GLY B  53
MET B  60
PHE B 278
 None
 1.48A 3vaqB-3pz2B:
undetectable		 3vaqB-3pz2B:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		3 / 3 VAL B 239
TRP B 243
TRP B 244
 None
GRG  B 334 ( 4.8A)
GRG  B 334 ( 3.8A)
 1.37A 3zq8A-3pz2B:
undetectable
3zq8B-3pz2B:
undetectable		 3zq8A-3pz2B:
4.01
3zq8B-3pz2B:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 6 GLU B 188
ASP B 178
SER B 189
PRO B 233
 None
 1.29A 4apjA-3pz2B:
undetectable
4apjP-3pz2B:
undetectable		 4apjA-3pz2B:
19.43
4apjP-3pz2B:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 8 THR B 198
LEU B 215
GLY B 216
VAL B 330
 None
 0.82A 4c9nA-3pz2B:
undetectable		 4c9nA-3pz2B:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 LEU B 298
VAL B  56
ILE B  27
GLY B 276
ILE B 295
 None
 0.90A 4dqbA-3pz2B:
undetectable		 4dqbA-3pz2B:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 LEU B 298
VAL B  56
ILE B  27
GLY B 276
ILE B 295
 None
 0.88A 4dqfA-3pz2B:
undetectable		 4dqfA-3pz2B:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 8 TYR B  51
THR B  55
LEU B  59
VAL B 309
GLN B 103
 None
None
None
None
GRG  B 334 (-3.6A)
 1.45A 4em2A-3pz2B:
undetectable		 4em2A-3pz2B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 11 LEU B 298
VAL B  56
ILE B  27
GLY B 276
ILE B 295
 None
 0.94A 4njtA-3pz2B:
undetectable		 4njtA-3pz2B:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 11 LEU B 229
SER B 242
SER B 226
ASP B   7
LEU B 263
 None
 1.35A 4or0A-3pz2B:
undetectable		 4or0A-3pz2B:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 11 LEU B 298
VAL B  56
ILE B  27
GLY B 276
ILE B 295
 None
 0.87A 4rvjA-3pz2B:
undetectable		 4rvjA-3pz2B:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 11 LEU B 298
VAL B  56
ILE B  27
GLY B 276
ILE B 295
 None
 0.87A 4rvjC-3pz2B:
undetectable		 4rvjC-3pz2B:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 11 LEU B  59
VAL B  56
LEU B  18
GLY B 277
SER B 299
 None
 1.35A 4zbqA-3pz2B:
undetectable		 4zbqA-3pz2B:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 7 ILE B 194
CYH B 197
GLY B 179
GLY B 180
 None
 0.70A 5a06A-3pz2B:
undetectable		 5a06A-3pz2B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 7 ILE B 194
CYH B 197
GLY B 179
GLY B 180
 None
 0.67A 5a06B-3pz2B:
undetectable		 5a06B-3pz2B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 7 ILE B 194
CYH B 197
GLY B 179
GLY B 180
 None
 0.71A 5a06C-3pz2B:
undetectable		 5a06C-3pz2B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 7 ILE B 194
CYH B 197
GLY B 179
GLY B 180
 None
 0.69A 5a06E-3pz2B:
undetectable		 5a06E-3pz2B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 7 ILE B 194
CYH B 197
GLY B 179
GLY B 180
 None
 0.72A 5a06F-3pz2B:
undetectable		 5a06F-3pz2B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 12 GLN B 271
ILE B 295
GLY B 297
PHE B 293
PRO B 282
 None
None
None
GRG  B 334 (-4.7A)
None
 1.13A 5ergB-3pz2B:
undetectable		 5ergB-3pz2B:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 5 HIS B 290
VAL B  56
GLY B 297
ALA B 296
 ZN  B   1 ( 3.2A)
None
None
None
 1.02A 5hwaA-3pz2B:
undetectable		 5hwaA-3pz2B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		5 / 9 ASP B  92
ILE B 137
GLY B 139
ILE B 141
VAL B 123
 None
 1.16A 5kr0A-3pz2B:
undetectable		 5kr0A-3pz2B:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 6 LEU B 215
SER B 212
ASP B 213
HIS B 256
 None
 1.20A 5om3A-3pz2B:
undetectable
5om3B-3pz2B:
undetectable		 5om3A-3pz2B:
12.65
5om3B-3pz2B:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 6 ILE B 252
ILE B 168
LEU B 172
PHE B 181
 None
 1.01A 5vkqB-3pz2B:
undetectable
5vkqC-3pz2B:
undetectable		 5vkqB-3pz2B:
11.28
5vkqC-3pz2B:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 6 ILE B 252
ILE B 168
LEU B 172
PHE B 181
 None
 1.01A 5vkqC-3pz2B:
undetectable
5vkqD-3pz2B:
undetectable		 5vkqC-3pz2B:
11.28
5vkqD-3pz2B:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA
(Rattus
norvegicus) 		4 / 6 LEU B 300
ALA B 247
SER B 310
THR B  55
 None
 0.98A 6f88A-3pz2B:
undetectable		 6f88A-3pz2B:
12.25