SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		4 / 6 HIS A 379
GLY A 389
ALA A 374
GLU A 371
 None
 0.92A 1dmaB-3pz6A:
undetectable		 1dmaB-3pz6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		5 / 10 ILE A 367
ALA A 373
ASN A 383
ILE A 361
THR A 431
 None
 1.23A 1j3jA-3pz6A:
undetectable		 1j3jA-3pz6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		4 / 7 LEU A 268
VAL A 407
VAL A 350
ILE A 433
 None
 0.98A 1t87B-3pz6A:
undetectable		 1t87B-3pz6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		5 / 11 ILE A 367
ALA A 373
ASN A 383
ILE A 361
THR A 431
 None
 1.16A 2blaA-3pz6A:
undetectable		 2blaA-3pz6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		4 / 5 ILE A 510
LEU A 507
ASP A 444
ALA A 489
 None
 0.86A 2opxA-3pz6A:
undetectable		 2opxA-3pz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		5 / 11 LEU A 320
GLY A 357
ILE A 361
VAL A 325
ILE A 394
 None
 0.97A 3el1A-3pz6A:
undetectable		 3el1A-3pz6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		4 / 8 ILE A 397
PHE A 393
ASN A 323
LEU A 320
 None
 0.96A 3hrdA-3pz6A:
undetectable
3hrdB-3pz6A:
undetectable		 3hrdA-3pz6A:
21.71
3hrdB-3pz6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		5 / 12 LEU A 320
GLY A 357
ILE A 361
VAL A 325
ILE A 394
 None
 0.97A 3nduB-3pz6A:
undetectable		 3nduB-3pz6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		5 / 7 LEU A 266
THR A 336
ALA A 334
LEU A 332
THR A 431
 None
 1.39A 4d7bA-3pz6A:
undetectable		 4d7bA-3pz6A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		4 / 8 HIS A 379
GLY A 389
ALA A 374
GLU A 371
 None
 0.92A 4hyfC-3pz6A:
undetectable		 4hyfC-3pz6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		4 / 7 LEU A 382
ASN A 383
LEU A 333
ILE A 394
 None
 1.04A 4okwA-3pz6A:
undetectable		 4okwA-3pz6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		5 / 12 ALA A 405
VAL A 419
LEU A 332
SER A 398
ILE A 397
 None
 1.07A 4pd9A-3pz6A:
undetectable		 4pd9A-3pz6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		4 / 7 GLY A 344
GLN A 345
TYR A 448
SER A 439
 None
 1.16A 4ws0A-3pz6A:
undetectable		 4ws0A-3pz6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		5 / 9 LEU A 404
LEU A 470
PRO A 421
ILE A 451
LEU A 452
 None
 1.34A 5g48B-3pz6A:
undetectable		 5g48B-3pz6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		5 / 12 ASP A 543
PRO A 339
THR A 435
GLY A 263
THR A 431
 None
 1.34A 5hfjH-3pz6A:
undetectable		 5hfjH-3pz6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 3pz6 LEUCYL-TRNA
SYNTHETASE
(Giardia
intestinalis) 		4 / 8 GLY A 522
ILE A 523
ASP A 440
PRO A 477
 None
 0.93A 6ag0A-3pz6A:
undetectable		 6ag0A-3pz6A:
13.50