SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pz9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 VAL A 230
VAL A 232
TRP A 193
 None
 0.73A 1bdwA-3pz9A:
undetectable
1bdwB-3pz9A:
undetectable		 1bdwA-3pz9A:
3.37
1bdwB-3pz9A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 GLU A 317
ASN A  43
TRP A  73
 None
 1.18A 1r15C-3pz9A:
2.2		 1r15C-3pz9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 GLU A 317
ASN A  43
TRP A  73
 None
 1.23A 1r15D-3pz9A:
2.2		 1r15D-3pz9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 GLU A 317
ASN A  43
TRP A  73
 None
 1.19A 1r15E-3pz9A:
undetectable		 1r15E-3pz9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 GLU A 317
ASN A  43
TRP A  73
 None
 1.18A 1r15F-3pz9A:
undetectable		 1r15F-3pz9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		4 / 8 MET A  89
ASP A  77
TYR A 168
HIS A  48
 None
 1.16A 2bteA-3pz9A:
undetectable		 2bteA-3pz9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		4 / 5 TRP A 298
ALA A 251
LEU A 279
ALA A 254
 None
 1.24A 2jstA-3pz9A:
undetectable
2jstB-3pz9A:
undetectable		 2jstA-3pz9A:
10.47
2jstB-3pz9A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		6 / 12 ASN A 197
GLU A 198
HIS A 278
TYR A 280
GLU A 317
TRP A 350
 None
 0.85A 2v3dA-3pz9A:
7.9		 2v3dA-3pz9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		4 / 7 TYR A 318
TRP A 335
GLU A 388
TYR A 389
 None
 1.44A 2xytG-3pz9A:
0.0		 2xytG-3pz9A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		4 / 7 TYR A 318
TRP A 335
GLU A 388
TYR A 389
 None
 1.40A 2xytH-3pz9A:
0.0		 2xytH-3pz9A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 GLU A 357
ASP A  56
TYR A 114
 None
 0.60A 2yvlB-3pz9A:
1.7		 2yvlB-3pz9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 12 ALA A 306
ILE A 303
SER A 268
ALA A 231
ASP A 345
 None
 1.13A 3axtA-3pz9A:
2.0		 3axtA-3pz9A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 12 TYR A 184
HIS A 175
ASP A 113
PRO A 188
ILE A 190
 None
 1.42A 3b7pA-3pz9A:
undetectable		 3b7pA-3pz9A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 12 TYR A 184
HIS A 175
ASP A 113
PRO A 188
ILE A 190
 None
 1.40A 3b7pC-3pz9A:
undetectable		 3b7pC-3pz9A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 10 ARG A  53
ILE A 355
GLY A 354
ALA A 353
TYR A  46
 None
 1.45A 3boyA-3pz9A:
undetectable
3boyC-3pz9A:
undetectable		 3boyA-3pz9A:
17.23
3boyC-3pz9A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 10 TYR A  46
ARG A  53
ILE A 355
GLY A 354
ALA A 353
 None
 1.44A 3boyA-3pz9A:
undetectable
3boyB-3pz9A:
undetectable		 3boyA-3pz9A:
17.23
3boyB-3pz9A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 10 TYR A  46
ARG A  53
ILE A 355
GLY A 354
ALA A 353
 None
 1.44A 3boyB-3pz9A:
undetectable
3boyC-3pz9A:
undetectable		 3boyB-3pz9A:
17.23
3boyC-3pz9A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 9 VAL A 313
LEU A 342
TYR A 389
LEU A 338
ASP A 337
 None
 1.44A 3hthB-3pz9A:
1.1		 3hthB-3pz9A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		4 / 8 ASN A 133
HIS A 152
ASN A 141
MET A 140
 None
 1.27A 3kp6A-3pz9A:
undetectable
3kp6B-3pz9A:
undetectable		 3kp6A-3pz9A:
16.84
3kp6B-3pz9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		4 / 8 ARG A 387
GLU A 384
GLU A 382
ARG A 328
 None
 1.05A 4bqfB-3pz9A:
undetectable		 4bqfB-3pz9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 TYR A 318
MET A 348
ILE A  72
 None
 0.89A 4c8bB-3pz9A:
undetectable		 4c8bB-3pz9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 12 GLU A 316
ILE A 127
LEU A 195
ASP A 273
LEU A 229
 None
 1.18A 4foxA-3pz9A:
undetectable		 4foxA-3pz9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 12 GLU A 316
ILE A 127
LEU A 195
ASP A 273
LEU A 229
 None
 1.18A 4foxB-3pz9A:
undetectable		 4foxB-3pz9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 12 GLU A 316
ILE A 127
LEU A 195
ASP A 273
LEU A 229
 None
 1.11A 4foxG-3pz9A:
undetectable		 4foxG-3pz9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 ASP A 113
LEU A 112
PHE A 109
 None
 0.49A 4pthA-3pz9A:
undetectable		 4pthA-3pz9A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		4 / 8 GLY A 108
ILE A 102
GLY A  97
PHE A 109
 None
 0.86A 5alcL-3pz9A:
undetectable		 5alcL-3pz9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 THR A 189
MET A 191
HIS A 228
 None
 0.82A 5uunA-3pz9A:
undetectable		 5uunA-3pz9A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 12 GLY A 344
GLY A 346
ASN A 336
ALA A 347
ASP A 341
 None
 1.09A 6b3aA-3pz9A:
undetectable		 6b3aA-3pz9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		5 / 12 GLY A 344
GLY A 346
ASN A 336
ALA A 347
ASP A 341
 None
 1.10A 6b3bA-3pz9A:
2.7		 6b3bA-3pz9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5
(Thermotoga
petrophila) 		3 / 3 ASP A 362
ASP A 371
ASN A 197
 None
 0.85A 6gngB-3pz9A:
undetectable		 6gngB-3pz9A:
21.97