SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		4 / 5 PHE A 268
VAL A 254
VAL A 271
ASP A 269
 None
 1.34A 1dz6B-3pzlA:
undetectable		 1dz6B-3pzlA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 9 PHE A 268
VAL A 254
VAL A 271
ASP A 269
ILE A 270
 None
 1.43A 1gebA-3pzlA:
undetectable		 1gebA-3pzlA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		4 / 7 SER A 147
GLU A 188
GLU A 187
GLU A 190
 None
 1.15A 1knyA-3pzlA:
undetectable
1knyB-3pzlA:
undetectable		 1knyA-3pzlA:
22.22
1knyB-3pzlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		4 / 8 SER A 147
ASP A 148
GLU A 188
GLU A 187
 None
MN  A 314 (-2.3A)
None
None
 1.00A 1knyA-3pzlA:
undetectable
1knyB-3pzlA:
undetectable		 1knyA-3pzlA:
22.22
1knyB-3pzlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		4 / 8 ARG A 223
SER A 221
ARG A 175
VAL A 224
 None
 1.15A 1u1jA-3pzlA:
undetectable		 1u1jA-3pzlA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		4 / 6 SER A 274
LEU A 276
SER A  54
ASP A  45
 None
 1.17A 2j2pE-3pzlA:
undetectable
2j2pF-3pzlA:
undetectable		 2j2pE-3pzlA:
21.15
2j2pF-3pzlA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 8 PHE A 268
VAL A 254
VAL A 271
ASP A 269
ILE A 270
 None
 1.44A 2qbmA-3pzlA:
undetectable		 2qbmA-3pzlA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 10 PHE A 268
VAL A 254
VAL A 271
ASP A 269
ILE A 270
 None
 1.43A 2qboA-3pzlA:
undetectable		 2qboA-3pzlA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 12 ASP A  86
ILE A  42
ASP A  89
ARG A  62
ALA A 286
 None
 1.28A 2qmjA-3pzlA:
undetectable		 2qmjA-3pzlA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 9 HIS A 146
ASP A 148
HIS A 160
GLU A 188
THR A 243
 MN  A 315 (-3.8A)
MN  A 314 (-2.3A)
None
None
None
 0.69A 3gn0A-3pzlA:
30.2		 3gn0A-3pzlA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 9 HIS A 146
ASP A 148
HIS A 160
GLU A 188
THR A 243
 MN  A 315 (-3.8A)
MN  A 314 (-2.3A)
None
None
None
 0.66A 3gn0B-3pzlA:
30.4		 3gn0B-3pzlA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		3 / 3 LYS A 288
ARG A 255
LYS A 302
 None
 1.31A 3okxA-3pzlA:
undetectable		 3okxA-3pzlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 11 SER A 151
THR A 127
ARG A 165
SER A 178
HIS A 124
 None
None
None
None
MN  A 314 (-3.3A)
 1.37A 4bb2A-3pzlA:
undetectable
4bb2B-3pzlA:
undetectable		 4bb2A-3pzlA:
20.97
4bb2B-3pzlA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		3 / 3 LEU A 290
ILE A  61
ARG A  62
 None
 0.61A 4mk4B-3pzlA:
2.3		 4mk4B-3pzlA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 9 ALA A 130
ILE A  42
GLY A 121
ILE A 270
VAL A 107
 None
 1.16A 4nptA-3pzlA:
undetectable		 4nptA-3pzlA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 12 TYR A 225
VAL A 103
ILE A 100
LEU A 171
LEU A 170
 None
 1.36A 4yvpB-3pzlA:
undetectable		 4yvpB-3pzlA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		4 / 6 ALA A 145
SER A 183
ASP A 234
PRO A 235
 MN  A 315 ( 4.9A)
None
None
None
 0.75A 5c6pA-3pzlA:
undetectable		 5c6pA-3pzlA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 7 VAL A 292
SER A 296
ALA A 295
GLY A  76
ARG A 255
 None
 1.30A 5fpdB-3pzlA:
undetectable		 5fpdB-3pzlA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		4 / 6 ILE A 181
GLY A 209
ASN A 208
ILE A 179
 None
 1.01A 5j4nB-3pzlA:
undetectable		 5j4nB-3pzlA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		3 / 3 VAL A  96
TYR A 158
GLU A 123
 None
 0.93A 5zmqD-3pzlA:
undetectable
5zmqE-3pzlA:
undetectable		 5zmqD-3pzlA:
21.91
5zmqE-3pzlA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		5 / 12 ILE A 294
TYR A  37
ALA A  57
ALA A 286
PHE A 273
 None
 0.98A 5zw4A-3pzlA:
4.1		 5zw4A-3pzlA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		3 / 3 ARG A 260
LYS A 264
TYR A 300
 None
 1.26A 6gnaA-3pzlA:
1.8		 6gnaA-3pzlA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3pzl AGMATINE
UREOHYDROLASE
(Thermoplasma
volcanium) 		3 / 3 ARG A 260
LYS A 264
TYR A 300
 None
 1.26A 6gnbA-3pzlA:
1.8		 6gnbA-3pzlA:
24.77