SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3pzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
 None
None
None
None
NAP  A 372 (-3.1A)
 0.96A 1d4sA-3pzrA:
undetectable		 1d4sA-3pzrA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 10 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
None
None
None
NAP  A 372 (-3.1A)
None
 1.08A 1d4yA-3pzrA:
undetectable		 1d4yA-3pzrA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 ARG A 361
ARG A 360
ILE A  94
 None
 0.70A 1uobA-3pzrA:
undetectable		 1uobA-3pzrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 5 LEU A 352
ASP A 349
GLY A 165
ALA A 356
 None
None
CYS  A 371 (-3.4A)
None
 0.95A 2aohA-3pzrA:
undetectable		 2aohA-3pzrA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 4 VAL A 302
LEU A 282
ILE A 286
LEU A 288
 None
 1.04A 2byoA-3pzrA:
1.3		 2byoA-3pzrA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 SER A  14
THR A  36
GLN A  72
 None
NAP  A 372 (-3.1A)
NAP  A 372 (-3.6A)
 0.74A 2fk8A-3pzrA:
undetectable		 2fk8A-3pzrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 THR A 135
GLN A 276
VAL A 152
ALA A 157
VAL A 259
 None
 1.00A 2g72B-3pzrA:
2.7		 2g72B-3pzrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
 None
None
None
None
NAP  A 372 (-3.1A)
 1.01A 2o4nA-3pzrA:
undetectable		 2o4nA-3pzrA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 11 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
None
None
None
NAP  A 372 (-3.1A)
None
 1.06A 2o4pA-3pzrA:
undetectable		 2o4pA-3pzrA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 SER A 275
TYR A 160
HIS A 274
 None
None
CYS  A 371 (-3.9A)
 0.71A 2r2vD-3pzrA:
undetectable		 2r2vD-3pzrA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 12 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
None
None
None
NAP  A 372 (-3.1A)
None
 1.09A 3k4vA-3pzrA:
undetectable		 3k4vA-3pzrA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 TYR A 147
GLU A 153
LEU A 252
ASN A 249
 None
 1.41A 3k8mA-3pzrA:
undetectable		 3k8mA-3pzrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 10 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
None
None
None
NAP  A 372 (-3.1A)
None
 1.22A 3lzvA-3pzrA:
undetectable		 3lzvA-3pzrA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 12 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
None
None
None
NAP  A 372 (-3.1A)
None
 1.10A 3ndtA-3pzrA:
undetectable		 3ndtA-3pzrA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 9 ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
None
None
NAP  A 372 (-3.1A)
None
 1.07A 3ndwB-3pzrA:
undetectable		 3ndwB-3pzrA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 LEU A 351
ALA A  96
ASP A  95
ILE A  69
VAL A  15
 None
 1.01A 3oxwC-3pzrA:
undetectable		 3oxwC-3pzrA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 11 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
None
None
None
NAP  A 372 (-3.1A)
None
 1.15A 3oxxD-3pzrA:
undetectable		 3oxxD-3pzrA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 12 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
None
None
None
NAP  A 372 (-3.1A)
None
 1.15A 3tl9A-3pzrA:
undetectable		 3tl9A-3pzrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 9 THR A 346
LEU A 143
GLY A 144
VAL A 304
VAL A 329
 None
 1.46A 4c9kB-3pzrA:
undetectable		 4c9kB-3pzrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 9 THR A 346
LEU A 146
LEU A 143
GLY A 144
VAL A 304
 None
 1.23A 4c9kB-3pzrA:
undetectable		 4c9kB-3pzrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 8 THR A 346
LEU A 146
LEU A 143
GLY A 144
VAL A 304
 None
 1.19A 4c9nA-3pzrA:
undetectable		 4c9nA-3pzrA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 10 THR A 346
LEU A 146
LEU A 143
GLY A 144
VAL A 304
 None
 1.20A 4c9nB-3pzrA:
undetectable		 4c9nB-3pzrA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 ILE A  94
TRP A 353
GLY A 132
ASN A 114
 None
 0.92A 4fgjA-3pzrA:
2.6
4fgjB-3pzrA:
3.1		 4fgjA-3pzrA:
22.22
4fgjB-3pzrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 8 HIS A 298
GLY A 145
ALA A 142
TYR A 147
 None
 0.92A 4hyfC-3pzrA:
undetectable		 4hyfC-3pzrA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 11 LEU A 367
VAL A   3
ILE A  69
MET A  20
LEU A  16
 None
 0.92A 4lhmA-3pzrA:
undetectable		 4lhmA-3pzrA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
 None
None
None
None
NAP  A 372 (-3.1A)
 1.01A 4njuA-3pzrA:
undetectable		 4njuA-3pzrA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
 None
None
None
None
NAP  A 372 (-3.1A)
 1.01A 4njuC-3pzrA:
undetectable		 4njuC-3pzrA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 5 GLN A 117
HIS A 124
ILE A 107
ILE A 122
 None
 1.06A 5dnvA-3pzrA:
2.3		 5dnvA-3pzrA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 6 GLU A 357
ARG A  19
LEU A  16
ARG A 360
 None
 1.19A 5l6eA-3pzrA:
undetectable
5l6eB-3pzrA:
undetectable		 5l6eA-3pzrA:
20.32
5l6eB-3pzrA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 ALA A  97
GLN A  72
THR A  77
 None
NAP  A 372 (-3.6A)
None
 0.64A 5n0oA-3pzrA:
undetectable		 5n0oA-3pzrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 6 ARG A 361
ARG A  19
ALA A 356
PRO A 358
 None
 1.24A 5odqA-3pzrA:
undetectable		 5odqA-3pzrA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 11 LEU A 252
LEU A 140
SER A 137
THR A 109
LEU A 110
VAL A 113
 None
 1.36A 5twjD-3pzrA:
undetectable		 5twjD-3pzrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A 143
GLY A 330
ALA A 142
PRO A 306
GLU A 308
 None
 1.24A 5x6yC-3pzrA:
4.0		 5x6yC-3pzrA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 MET A 141
ASP A 111
ARG A  19
 None
 1.12A 5z6jA-3pzrA:
undetectable		 5z6jA-3pzrA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		3 / 3 MET A 141
ASP A 111
ARG A  19
 None
 1.07A 5z6kA-3pzrA:
undetectable		 5z6kA-3pzrA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		5 / 12 LEU A 351
ALA A  96
ASP A  95
ILE A  69
VAL A  15
 None
 1.01A 6difA-3pzrA:
undetectable		 6difA-3pzrA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		6 / 12 LEU A 351
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
None
None
None
NAP  A 372 (-3.1A)
None
 1.05A 6dilA-3pzrA:
undetectable		 6dilA-3pzrA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 7 VAL A  15
LEU A 325
GLY A 323
GLY A 165
 None
None
None
CYS  A 371 (-3.4A)
 0.76A 6eu9D-3pzrA:
undetectable		 6eu9D-3pzrA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Vibrio
cholerae) 		4 / 6 LEU A  84
TYR A  81
VAL A  12
GLY A  91
 None
None
NAP  A 372 (-3.7A)
None
 1.04A 6hd4B-3pzrA:
undetectable		 6hd4B-3pzrA:
13.75