SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q0g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.43A 1a52A-3q0gA:
undetectable		 1a52A-3q0gA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.43A 1a52B-3q0gA:
undetectable		 1a52B-3q0gA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.36A 1ereA-3q0gA:
undetectable		 1ereA-3q0gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.36A 1ereB-3q0gA:
undetectable		 1ereB-3q0gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.37A 1ereC-3q0gA:
undetectable		 1ereC-3q0gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.36A 1ereD-3q0gA:
undetectable		 1ereD-3q0gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.35A 1ereE-3q0gA:
undetectable		 1ereE-3q0gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.37A 1ereF-3q0gA:
undetectable		 1ereF-3q0gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.33A 1pcgA-3q0gA:
undetectable		 1pcgA-3q0gA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.34A 1pcgB-3q0gA:
undetectable		 1pcgB-3q0gA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.30A 1qkuA-3q0gA:
undetectable		 1qkuA-3q0gA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.30A 1qkuB-3q0gA:
undetectable		 1qkuB-3q0gA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.30A 1qkuC-3q0gA:
undetectable		 1qkuC-3q0gA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 106
CYH A 110
LEU A 112
ALA A 113
PHE A 127
 None
 1.30A 1s9pB-3q0gA:
undetectable		 1s9pB-3q0gA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 12 THR A  18
LEU A  19
ILE A   6
ASN A  29
LEU A 112
 None
 1.27A 1wsvA-3q0gA:
undetectable		 1wsvA-3q0gA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		4 / 8 TRP A  87
LEU A  19
GLY A 109
ALA A  62
 None
 0.89A 2xfsA-3q0gA:
undetectable		 2xfsA-3q0gA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		4 / 8 TRP A  87
LEU A  19
GLY A 109
ALA A  62
 None
 0.92A 2xh9A-3q0gA:
undetectable		 2xh9A-3q0gA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 119
THR A  55
ALA A 125
ALA A 102
 None
 0.99A 3ax9B-3q0gA:
undetectable		 3ax9B-3q0gA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		4 / 4 ILE A  17
ARG A 145
ILE A  54
THR A   5
 None
 1.13A 3ia4C-3q0gA:
undetectable		 3ia4C-3q0gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.28A 3olsB-3q0gA:
undetectable		 3olsB-3q0gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.37A 3uudB-3q0gA:
undetectable		 3uudB-3q0gA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 121
PHE A 127
ALA A 105
ALA A  99
 None
 0.86A 4du2A-3q0gA:
undetectable		 4du2A-3q0gA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 121
PHE A 127
ALA A 105
ALA A  99
 None
 0.82A 4du2B-3q0gA:
undetectable		 4du2B-3q0gA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.38A 5dxeB-3q0gA:
undetectable		 5dxeB-3q0gA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.39A 5hyrA-3q0gA:
undetectable		 5hyrA-3q0gA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.43A 5hyrB-3q0gA:
undetectable		 5hyrB-3q0gA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.39A 5wgdA-3q0gA:
undetectable		 5wgdA-3q0gA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.33A 5wgqB-3q0gA:
undetectable		 5wgqB-3q0gA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 101
GLY A 109
ALA A 105
LEU A 175
LEU A 119
 None
 1.02A 5x23A-3q0gA:
undetectable		 5x23A-3q0gA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 101
GLY A 109
ALA A 105
LEU A 175
LEU A 119
 None
 1.03A 5xxiA-3q0gA:
undetectable		 5xxiA-3q0gA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3q0g ENOYL-COA HYDRATASE
ECHA8
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 205
LYS A 208
ARG A 178
 None
 1.20A 6c06D-3q0gA:
3.8		 6c06D-3q0gA:
undetectable