SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		5 / 12 HIS A  34
GLY A  36
GLY A 149
ASP A 152
VAL A 178
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-3.3A)
AMP  A 501 (-3.6A)
AMP  A 501 (-4.0A)
 0.92A 1ffyA-3q10A:
2.3		 1ffyA-3q10A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		3 / 3 ARG A 189
ARG A  73
ARG A 123
 CL  A 607 (-3.4A)
None
CL  A 607 (-3.1A)
 0.78A 1l7fA-3q10A:
undetectable		 1l7fA-3q10A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		3 / 3 ARG A 189
ARG A  73
ARG A 123
 CL  A 607 (-3.4A)
None
CL  A 607 (-3.1A)
 0.82A 1l7hA-3q10A:
undetectable		 1l7hA-3q10A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		6 / 11 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
VAL A 178
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.1A)
AMP  A 501 (-3.3A)
AMP  A 501 (-3.6A)
AMP  A 501 (-4.0A)
 0.93A 1pg2A-3q10A:
undetectable		 1pg2A-3q10A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		6 / 12 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
VAL A 178
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.1A)
AMP  A 501 (-3.3A)
AMP  A 501 (-3.6A)
AMP  A 501 (-4.0A)
 0.98A 1qu2A-3q10A:
2.2		 1qu2A-3q10A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		5 / 12 HIS A  34
GLY A  36
HIS A  37
ASP A 152
VAL A 178
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.1A)
AMP  A 501 (-3.6A)
AMP  A 501 (-4.0A)
 1.02A 1qu3A-3q10A:
undetectable		 1qu3A-3q10A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		5 / 10 ALA A 201
LEU A 193
LEU A 269
ALA A 272
LEU A 233
 None
 1.24A 2bxeA-3q10A:
undetectable		 2bxeA-3q10A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		4 / 6 ILE A 222
ARG A 246
LEU A 254
LEU A 226
 None
 0.95A 2rlfA-3q10A:
undetectable
2rlfD-3q10A:
undetectable		 2rlfA-3q10A:
8.13
2rlfD-3q10A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		4 / 7 ASN A 139
SER A 135
TYR A 168
VAL A 109
 None
 1.04A 2uz2A-3q10A:
undetectable		 2uz2A-3q10A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		5 / 11 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.1A)
AMP  A 501 (-3.3A)
AMP  A 501 (-3.6A)
 0.98A 2x1lA-3q10A:
6.7		 2x1lA-3q10A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		5 / 12 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.1A)
AMP  A 501 (-3.3A)
AMP  A 501 (-3.6A)
 0.91A 2x1lB-3q10A:
6.6		 2x1lB-3q10A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		5 / 11 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.1A)
AMP  A 501 (-3.3A)
AMP  A 501 (-3.6A)
 0.94A 2x1lC-3q10A:
6.6		 2x1lC-3q10A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		4 / 8 GLY A  86
ALA A  87
ASP A  88
THR A  29
 None
None
None
AMP  A 501 ( 4.7A)
 0.61A 3el0A-3q10A:
undetectable		 3el0A-3q10A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		5 / 10 ALA A 248
LEU A 282
VAL A 280
ILE A 222
ILE A 263
 IMD  A 606 ( 4.8A)
None
None
None
None
 1.13A 3jw3A-3q10A:
undetectable		 3jw3A-3q10A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		4 / 8 HIS A  37
TYR A 192
LEU A 274
SER A 188
 AMP  A 501 (-4.1A)
None
None
AMP  A 501 ( 4.9A)
 0.91A 3lm8B-3q10A:
undetectable
3lm8D-3q10A:
undetectable		 3lm8B-3q10A:
22.18
3lm8D-3q10A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		4 / 6 GLN A 155
HIS A  37
HIS A  34
ASP A 152
 GOL  A 601 (-3.0A)
AMP  A 501 (-4.1A)
AMP  A 501 (-4.4A)
AMP  A 501 (-3.6A)
 1.06A 3nvcA-3q10A:
undetectable		 3nvcA-3q10A:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		6 / 8 ARG A 123
HIS A 126
VAL A 130
VAL A 134
ASP A 152
ARG A 189
 CL  A 607 (-3.1A)
CL  A 607 (-4.3A)
GOL  A 601 (-4.0A)
None
AMP  A 501 (-3.6A)
CL  A 607 (-3.4A)
 1.46A 3uy4A-3q10A:
38.6		 3uy4A-3q10A:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		7 / 8 GLN A  61
ARG A 123
HIS A 126
VAL A 130
ASP A 152
GLN A 155
ARG A 189
 GOL  A 601 ( 2.9A)
CL  A 607 (-3.1A)
CL  A 607 (-4.3A)
GOL  A 601 (-4.0A)
AMP  A 501 (-3.6A)
GOL  A 601 (-3.0A)
CL  A 607 (-3.4A)
 0.36A 3uy4A-3q10A:
38.6		 3uy4A-3q10A:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		4 / 5 ASP A  49
VAL A  50
TRP A  17
GLU A  20
 None
 1.48A 4qzuA-3q10A:
0.0
4qzuD-3q10A:
0.0		 4qzuA-3q10A:
17.50
4qzuD-3q10A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		3 / 3 SER A 188
TYR A  71
ASP A  78
 AMP  A 501 ( 4.9A)
None
None
 0.84A 4rp8C-3q10A:
undetectable		 4rp8C-3q10A:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		10 / 12 HIS A  34
GLY A  36
LEU A  40
GLN A  61
TYR A  71
GLY A 149
LYS A 151
ASP A 152
THR A 177
LEU A 186
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.6A)
GOL  A 601 ( 2.9A)
None
AMP  A 501 (-3.3A)
None
AMP  A 501 (-3.6A)
AMP  A 501 (-4.2A)
AMP  A 501 (-4.4A)
 0.53A 5hg0A-3q10A:
34.0		 5hg0A-3q10A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		5 / 12 HIS A  34
GLY A  36
VAL A 134
ASP A 152
LEU A 186
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
None
AMP  A 501 (-3.6A)
AMP  A 501 (-4.4A)
 1.09A 5hg0A-3q10A:
34.0		 5hg0A-3q10A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		9 / 12 HIS A  34
GLY A  36
HIS A  37
LEU A  40
TYR A  71
GLY A 149
ASP A 152
THR A 177
LEU A 186
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.1A)
AMP  A 501 (-4.6A)
None
AMP  A 501 (-3.3A)
AMP  A 501 (-3.6A)
AMP  A 501 (-4.2A)
AMP  A 501 (-4.4A)
 0.27A 5hg0B-3q10A:
33.7		 5hg0B-3q10A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		5 / 12 HIS A  34
GLY A  36
HIS A  37
TYR A  71
VAL A 130
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.1A)
None
GOL  A 601 (-4.0A)
 1.08A 5hg0B-3q10A:
33.7		 5hg0B-3q10A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		6 / 12 HIS A  34
GLY A  36
HIS A  37
VAL A 134
ASP A 152
LEU A 186
 AMP  A 501 (-4.4A)
AMP  A 501 ( 3.9A)
AMP  A 501 (-4.1A)
None
AMP  A 501 (-3.6A)
AMP  A 501 (-4.4A)
 1.11A 5hg0B-3q10A:
33.7		 5hg0B-3q10A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		7 / 12 LEU A  40
TYR A  71
GLY A 149
LYS A 151
ASP A 152
THR A 177
LEU A 186
 AMP  A 501 (-4.6A)
None
AMP  A 501 (-3.3A)
None
AMP  A 501 (-3.6A)
AMP  A 501 (-4.2A)
AMP  A 501 (-4.4A)
 0.69A 5hg0B-3q10A:
33.7		 5hg0B-3q10A:
39.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		3 / 3 LEU A 254
LEU A 282
ARG A 220
 None
 0.54A 6fgcA-3q10A:
undetectable		 6fgcA-3q10A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3q10 PANTOATE--BETA-ALANI
NE LIGASE
(Yersinia
pestis) 		3 / 3 LEU A 254
LEU A 282
ARG A 220
 None
 0.51A 6fgdA-3q10A:
2.5		 6fgdA-3q10A:
23.53