SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		4 / 6 PHE A 356
GLU A 334
LYS A 362
VAL A 360
 None
 1.37A 1l2iB-3q15A:
undetectable		 1l2iB-3q15A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		4 / 6 LYS A 316
LEU A 320
ALA A 306
SER A 339
 None
 1.03A 1tz8C-3q15A:
undetectable
1tz8D-3q15A:
undetectable		 1tz8C-3q15A:
15.68
1tz8D-3q15A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		6 / 12 ALA A 246
ALA A 247
LEU A 258
LEU A 224
ALA A 220
LEU A 269
 None
 1.29A 2aclA-3q15A:
undetectable
2aclE-3q15A:
undetectable		 2aclA-3q15A:
21.41
2aclE-3q15A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		3 / 3 TYR A 297
GLY A 285
PHE A 263
 None
 0.60A 2m2pB-3q15A:
undetectable		 2m2pB-3q15A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		5 / 12 VAL A 240
ALA A 246
ALA A 247
LEU A 258
ALA A 220
 None
 0.84A 3fc6C-3q15A:
undetectable		 3fc6C-3q15A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		3 / 3 ARG A 232
LYS A 194
ARG A 338
 None
 0.83A 3w1wA-3q15A:
undetectable
3w1wB-3q15A:
undetectable		 3w1wA-3q15A:
21.88
3w1wB-3q15A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		3 / 3 ARG A 338
ARG A 232
LYS A 194
 None
 0.85A 3w1wA-3q15A:
undetectable
3w1wB-3q15A:
undetectable		 3w1wA-3q15A:
21.88
3w1wB-3q15A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		5 / 12 ALA A 246
ALA A 247
LEU A 258
LEU A 224
ALA A 220
 None
 1.04A 4k6iA-3q15A:
undetectable		 4k6iA-3q15A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		5 / 12 ALA A 246
ALA A 247
LEU A 224
ALA A 220
ILE A 282
 None
 1.08A 4nqaH-3q15A:
undetectable		 4nqaH-3q15A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		3 / 3 LEU A  62
ASP A  65
TYR A  66
 None
 0.35A 4qc6B-3q15A:
undetectable		 4qc6B-3q15A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H
(Bacillus
subtilis) 		3 / 3 GLU A 109
ARG A 105
TYR A 121
 None
 0.49A 5trqB-3q15A:
undetectable		 5trqB-3q15A:
22.72