SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 7 LEU A 174
LEU A 163
GLY A 166
LEU A 190
 None
 0.92A 1gtiA-3q1tA:
undetectable		 1gtiA-3q1tA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 8 ASP A 155
ASP A 144
LEU A 174
HIS A 146
 None
 1.12A 2q0iA-3q1tA:
undetectable		 2q0iA-3q1tA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_A_BEZA500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 10 ASP A 155
ASP A 144
LEU A 174
HIS A 146
SER A 240
 None
 1.26A 2q0jA-3q1tA:
undetectable		 2q0jA-3q1tA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 11 ASP A 155
ASP A 144
LEU A 174
HIS A 146
SER A 240
 None
 1.26A 2q0jB-3q1tA:
undetectable		 2q0jB-3q1tA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 6 LEU A  80
ALA A 123
LEU A  47
ALA A  48
 None
 0.99A 2vcvB-3q1tA:
undetectable		 2vcvB-3q1tA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 6 LEU A  80
ALA A 123
LEU A  47
ALA A  48
 None
 0.98A 2vcvK-3q1tA:
undetectable		 2vcvK-3q1tA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 10 VAL A  26
GLY A 206
ALA A 208
ALA A 204
THR A  28
 None
 1.16A 3ucjB-3q1tA:
undetectable		 3ucjB-3q1tA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 10 VAL A  65
PHE A  72
LEU A  31
VAL A  29
LEU A  47
 None
 1.07A 4e3hA-3q1tA:
undetectable		 4e3hA-3q1tA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 12 GLY A 122
ALA A  98
VAL A  39
VAL A  65
PHE A  72
 None
 1.06A 4wnwB-3q1tA:
undetectable		 4wnwB-3q1tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		3 / 3 LYS A 223
ARG A  61
VAL A  60
 None
 1.02A 4x3uA-3q1tA:
undetectable
4x3uB-3q1tA:
undetectable		 4x3uA-3q1tA:
13.01
4x3uB-3q1tA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 6 SER A 114
ARG A 138
GLY A 182
GLU A 183
 None
 1.04A 5btaA-3q1tA:
undetectable
5btaB-3q1tA:
undetectable
5btaC-3q1tA:
undetectable		 5btaA-3q1tA:
21.07
5btaB-3q1tA:
24.92
5btaC-3q1tA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 6 SER A 114
ARG A 138
GLY A 182
GLU A 183
 None
 1.08A 5btcA-3q1tA:
undetectable
5btcC-3q1tA:
undetectable
5btcD-3q1tA:
undetectable		 5btcA-3q1tA:
21.07
5btcC-3q1tA:
21.07
5btcD-3q1tA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 6 SER A 114
ARG A 138
GLY A 182
GLU A 183
 None
 1.09A 5btcA-3q1tA:
undetectable
5btcB-3q1tA:
undetectable
5btcC-3q1tA:
undetectable		 5btcA-3q1tA:
21.07
5btcB-3q1tA:
24.92
5btcC-3q1tA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 12 LEU A 211
ILE A 207
GLY A 206
THR A  28
VAL A 113
 None
 0.92A 5twjA-3q1tA:
undetectable		 5twjA-3q1tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 11 LEU A 211
ILE A 207
GLY A 206
THR A  28
VAL A 113
 None
 0.91A 5twjD-3q1tA:
undetectable		 5twjD-3q1tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3q1t ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 10 SER A 134
LEU A 180
LEU A 125
ILE A 188
GLY A 189
 None
 1.16A 6dm0B-3q1tA:
2.0
6dm0C-3q1tA:
undetectable		 6dm0B-3q1tA:
13.87
6dm0C-3q1tA:
13.87