SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 8 LEU A  93
ALA A   9
LEU A  96
THR A 102
 None
 0.92A 1dvtA-3q1xA:
undetectable
1dvtB-3q1xA:
undetectable		 1dvtA-3q1xA:
16.46
1dvtB-3q1xA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 ASP A 114
PHE A 177
GLY A 129
LEU A 122
ALA A 116
 None
 1.45A 1e3vA-3q1xA:
undetectable		 1e3vA-3q1xA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 11 ASP A 114
PHE A 177
GLY A 129
LEU A 122
ALA A 116
 None
 1.48A 1e3vB-3q1xA:
undetectable		 1e3vB-3q1xA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 10 ALA A 109
SER A 121
ALA A 117
PHE A 130
PHE A 176
 None
 1.26A 1g5yC-3q1xA:
2.9		 1g5yC-3q1xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 ALA A 236
GLY A 205
ILE A 242
VAL A 230
ILE A 232
 None
SER  A 314 ( 4.7A)
None
None
None
 0.84A 2fxeA-3q1xA:
undetectable		 2fxeA-3q1xA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 6 ILE A 164
TYR A 136
ILE A 198
HIS A 180
 None
 1.20A 3eteA-3q1xA:
undetectable
3eteE-3q1xA:
undetectable		 3eteA-3q1xA:
20.87
3eteE-3q1xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 5 ILE A 164
TYR A 136
ILE A 198
HIS A 180
 None
 1.21A 3eteB-3q1xA:
undetectable
3eteC-3q1xA:
undetectable		 3eteB-3q1xA:
20.87
3eteC-3q1xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 6 LEU A 103
VAL A 185
VAL A 158
ILE A 178
 None
 1.19A 3k5vA-3q1xA:
undetectable		 3k5vA-3q1xA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		4 / 6 LEU A 103
VAL A 185
VAL A 158
ILE A 178
 None
 1.22A 3k5vB-3q1xA:
undetectable		 3k5vB-3q1xA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 GLU A 153
LEU A 142
VAL A  89
ILE A  92
LEU A  65
 None
 1.41A 4k39A-3q1xA:
undetectable		 4k39A-3q1xA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		5 / 12 TYR A 199
THR A 231
ALA A 109
LEU A 107
GLY A 113
 None
 1.29A 5jglB-3q1xA:
undetectable		 5jglB-3q1xA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3q1x SERINE
ACETYLTRANSFERASE
(Entamoeba
histolytica) 		3 / 3 ILE A  56
THR A  57
PRO A  47
 None
 0.60A 6ncsA-3q1xA:
undetectable		 6ncsA-3q1xA:
21.74