SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
3 / 3 SER A  69
GLU A  68
GLU A  66
None
0.67A 1eqbD-3q34A:
undetectable
1eqbD-3q34A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
3 / 3 SER A  69
GLU A  68
GLU A  66
None
0.67A 1eqbB-3q34A:
undetectable
1eqbB-3q34A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
5 / 10 PHE A  86
ARG A 125
LEU A 124
PHE A  34
ILE A 155
None
None
UQ8  A   1 ( 4.7A)
UQ8  A   1 (-3.8A)
UQ8  A   1 ( 4.8A)
1.26A 1g5yC-3q34A:
undetectable
1g5yC-3q34A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
4 / 7 VAL A 187
SER A  30
ASN A  27
ASP A  26
None
None
GOL  A   3 (-4.3A)
None
1.29A 1hwiC-3q34A:
undetectable
1hwiC-3q34A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
4 / 7 VAL A 187
SER A  30
ASN A  27
ASP A  26
None
None
GOL  A   3 (-4.3A)
None
1.29A 1hwiD-3q34A:
undetectable
1hwiD-3q34A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
5 / 12 VAL A 182
LEU A 188
ALA A 186
LEU A  32
ALA A 133
None
None
UQ8  A   1 ( 4.4A)
UQ8  A   1 (-4.3A)
UQ8  A   1 ( 3.9A)
0.99A 1sa1A-3q34A:
undetectable
1sa1B-3q34A:
undetectable
1sa1A-3q34A:
16.89
1sa1B-3q34A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
5 / 12 VAL A 182
LEU A 188
ALA A 186
LEU A  32
ALA A 133
None
None
UQ8  A   1 ( 4.4A)
UQ8  A   1 (-4.3A)
UQ8  A   1 ( 3.9A)
1.01A 1sa1C-3q34A:
undetectable
1sa1D-3q34A:
undetectable
1sa1C-3q34A:
16.89
1sa1D-3q34A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
5 / 12 ILE A  96
LEU A  32
LEU A 124
ILE A 155
THR A 149
UQ8  A   1 (-3.6A)
UQ8  A   1 (-4.3A)
UQ8  A   1 ( 4.7A)
UQ8  A   1 ( 4.8A)
None
1.08A 2w3vA-3q34A:
undetectable
2w3vA-3q34A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
5 / 12 LEU A 124
LEU A 120
LEU A 153
LEU A  32
ALA A  94
UQ8  A   1 ( 4.7A)
UQ8  A   1 (-4.4A)
None
UQ8  A   1 (-4.3A)
UQ8  A   1 ( 4.4A)
1.14A 3dfrA-3q34A:
undetectable
3dfrA-3q34A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
4 / 7 ASN A  27
HIS A  52
LEU A  25
VAL A  65
GOL  A   3 (-4.3A)
None
None
None
0.85A 5m8rA-3q34A:
undetectable
5m8rA-3q34A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
4 / 8 ASN A  27
HIS A  52
LEU A  25
VAL A  65
GOL  A   3 (-4.3A)
None
None
None
0.84A 5m8rB-3q34A:
undetectable
5m8rB-3q34A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi)
4 / 8 ASN A  27
HIS A  52
LEU A  25
VAL A  65
GOL  A   3 (-4.3A)
None
None
None
0.74A 5m8rD-3q34A:
undetectable
5m8rD-3q34A:
16.48