SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 231
VAL A 225
TRP A 222
 None
 0.88A 1bdwA-3q3cA:
undetectable
1bdwB-3q3cA:
undetectable		 1bdwA-3q3cA:
4.44
1bdwB-3q3cA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 TRP A 214
ASN A 175
LEU A 178
PHE A 285
 None
 1.16A 1ru9H-3q3cA:
undetectable
1ru9L-3q3cA:
undetectable		 1ru9H-3q3cA:
20.93
1ru9L-3q3cA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A 134
GLY A 123
GLY A 124
GLY A 127
PHE A 159
 None
None
NAD  A 299 ( 4.1A)
None
None
 1.02A 1wg8A-3q3cA:
5.9		 1wg8A-3q3cA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 233
GLY A 124
THR A 125
ALA A 126
 None
NAD  A 299 ( 4.1A)
None
None
 0.79A 2a1hA-3q3cA:
undetectable
2a1hB-3q3cA:
undetectable		 2a1hA-3q3cA:
20.65
2a1hB-3q3cA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 233
GLY A 124
THR A 125
ALA A 126
 None
NAD  A 299 ( 4.1A)
None
None
 0.77A 2a1hA-3q3cA:
undetectable
2a1hB-3q3cA:
undetectable		 2a1hA-3q3cA:
20.65
2a1hB-3q3cA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 167
GLY A 165
ASP A 118
ALA A 119
HIS A 160
 None
 0.90A 2gluA-3q3cA:
5.8		 2gluA-3q3cA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 167
GLY A 165
ALA A 119
ALA A 161
HIS A 160
 None
 0.72A 2gluB-3q3cA:
4.8		 2gluB-3q3cA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 202
MET A 206
LEU A 216
MET A 189
 None
 1.20A 2kuhA-3q3cA:
undetectable		 2kuhA-3q3cA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  71
ILE A  97
PHE A 151
GLN A 168
SER A  63
 None
 1.39A 3apwB-3q3cA:
undetectable		 3apwB-3q3cA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 165
GLY A 138
GLY A 162
GLY A 167
 None
 0.49A 3bogC-3q3cA:
undetectable		 3bogC-3q3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 165
GLY A 138
GLY A 162
GLY A 167
 None
 0.48A 3bogD-3q3cA:
undetectable		 3bogD-3q3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  92
MET A  16
ALA A  17
LEU A  20
 None
 0.94A 3cldB-3q3cA:
undetectable		 3cldB-3q3cA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 143
LEU A  90
VAL A 137
ILE A  62
PHE A 151
 None
 1.38A 3fl9D-3q3cA:
undetectable		 3fl9D-3q3cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 151
GLY A 139
GLY A 162
ALA A 143
ARG A 103
 None
 0.80A 4krhA-3q3cA:
5.2		 4krhA-3q3cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 151
GLY A 139
GLY A 162
ALA A 143
ARG A 103
 None
 0.78A 4krhB-3q3cA:
5.1		 4krhB-3q3cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  40
LEU A  20
ASN A  19
MET A 154
ILE A  62
 None
 0.99A 4o2bB-3q3cA:
3.8		 4o2bB-3q3cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 247
ASN A 174
SER A  95
 NAD  A 299 (-3.8A)
None
None
 0.81A 4obwA-3q3cA:
5.1		 4obwA-3q3cA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  40
LEU A  20
ASN A  19
MET A 154
ILE A  62
 None
 0.97A 5mioB-3q3cA:
3.8		 5mioB-3q3cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 100
ARG A 103
ASP A 118
GLY A 167
 None
 1.26A 5mraA-3q3cA:
undetectable
5mraB-3q3cA:
undetectable		 5mraA-3q3cA:
18.79
5mraB-3q3cA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A  60
LYS A   2
ILE A  62
TYR A  25
 None
 1.42A 5q1sA-3q3cA:
undetectable		 5q1sA-3q3cA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A  37
ALA A  47
GLN A  34
 None
 0.65A 6gb9A-3q3cA:
undetectable		 6gb9A-3q3cA:
23.06