SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		5 / 12 ILE A 107
THR A 111
PHE A 149
LEU A 147
ILE A 134
 None
None
SO4  A 203 (-4.5A)
None
None
 1.00A 2cd2A-3q3fA:
undetectable		 2cd2A-3q3fA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		5 / 10 TYR A  13
TYR A  24
ILE A  96
ILE A  88
TYR A  90
 None
 1.38A 2dm6A-3q3fA:
undetectable
2dm6B-3q3fA:
undetectable		 2dm6A-3q3fA:
18.90
2dm6B-3q3fA:
18.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_A_DVAA35_0
(UBIQUITIN)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 4 GLN A 135
GLU A 138
ILE A 140
PRO A 141
 None
 0.84A 2fcnA-3q3fA:
14.0		 2fcnA-3q3fA:
44.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 6 GLN A 135
GLU A 138
ILE A 140
PRO A 141
 None
 0.78A 2fcnA-3q3fA:
14.0
2fcnB-3q3fA:
14.4		 2fcnA-3q3fA:
44.91
2fcnB-3q3fA:
44.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 7 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.75A 4w5oA-3q3fA:
undetectable		 4w5oA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 6 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.72A 4w5qA-3q3fA:
undetectable		 4w5qA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 6 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.86A 4w5tA-3q3fA:
undetectable		 4w5tA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 6 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.79A 4z4cA-3q3fA:
undetectable		 4z4cA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 6 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.75A 4z4dA-3q3fA:
undetectable		 4z4dA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 7 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.74A 4z4eA-3q3fA:
undetectable		 4z4eA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 7 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.73A 4z4gA-3q3fA:
undetectable		 4z4gA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN
(Bacillus
amyloliquefacien
s;
Homo
sapiens) 		4 / 6 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.81A 6cbdA-3q3fA:
undetectable		 6cbdA-3q3fA:
13.78