SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3q46 TT-IPPASE
(Thermococcus
thioreducens) 		4 / 6 LEU A 130
LEU A 107
PRO A  53
VAL A  54
 None
 1.11A 2dqyC-3q46A:
undetectable		 2dqyC-3q46A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3q46 TT-IPPASE
(Thermococcus
thioreducens) 		4 / 5 GLY A  10
PRO A   9
ILE A 167
ILE A 163
 None
 0.87A 2q9rA-3q46A:
undetectable		 2q9rA-3q46A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 3q46 TT-IPPASE
(Thermococcus
thioreducens) 		4 / 8 ASP A  43
TYR A  52
GLY A  57
ILE A  23
 EPE  A 309 ( 4.3A)
None
None
None
 0.78A 3ihzB-3q46A:
undetectable		 3ihzB-3q46A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3q46 TT-IPPASE
(Thermococcus
thioreducens) 		4 / 8 TYR A  52
GLU A  32
PHE A 136
ILE A 150
 None
MG  A 308 ( 2.6A)
None
None
 1.07A 3jz0B-3q46A:
undetectable		 3jz0B-3q46A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q46 TT-IPPASE
(Thermococcus
thioreducens) 		4 / 7 ILE A  93
GLY A 154
PHE A 116
ASP A 121
 None
 0.89A 5hieA-3q46A:
undetectable		 5hieA-3q46A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q46 TT-IPPASE
(Thermococcus
thioreducens) 		4 / 7 ILE A  93
GLY A 154
PHE A 116
ASP A 121
 None
 0.90A 5hieB-3q46A:
undetectable		 5hieB-3q46A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q46 TT-IPPASE
(Thermococcus
thioreducens) 		4 / 8 ILE A  93
GLY A 154
PHE A 116
ASP A 121
 None
 0.89A 5hieD-3q46A:
undetectable		 5hieD-3q46A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 3q46 TT-IPPASE
(Thermococcus
thioreducens) 		4 / 5 TYR A  52
LYS A  30
GLU A  22
GLY A  57
 None
PO4  A 301 ( 2.9A)
MG  A 305 ( 4.6A)
None
 1.22A 5jhdJ-3q46A:
undetectable		 5jhdJ-3q46A:
20.16