SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		5 / 10 LEU A  56
LEU A  59
ALA A  60
GLU A  63
LEU A 164
 None
 1.29A 1gwrA-3q4gA:
undetectable		 1gwrA-3q4gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		4 / 6 LEU A  40
GLN A  58
ILE A  98
PRO A 100
 None
CA  A 277 (-4.2A)
None
None
 0.95A 2fcnA-3q4gA:
undetectable
2fcnB-3q4gA:
undetectable		 2fcnA-3q4gA:
16.22
2fcnB-3q4gA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		6 / 12 LEU A  42
GLY A  47
ASP A  87
PRO A 100
ALA A  77
ILE A  44
 None
CA  A 279 (-3.6A)
None
None
None
None
 1.49A 2nmzA-3q4gA:
undetectable		 2nmzA-3q4gA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		4 / 6 ARG A 199
ASP A 241
ILE A 240
GLU A 171
 None
 1.44A 2ya7C-3q4gA:
undetectable		 2ya7C-3q4gA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		4 / 8 GLY A 160
ILE A 155
VAL A  41
GLN A  74
 None
 0.74A 3fi0B-3q4gA:
2.0		 3fi0B-3q4gA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		4 / 7 GLY A 160
ILE A 155
VAL A  41
GLN A  74
 None
 0.86A 3fi0E-3q4gA:
2.2		 3fi0E-3q4gA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		4 / 8 GLY A 160
ILE A 155
VAL A  41
GLN A  74
 None
 0.68A 3fi0G-3q4gA:
2.6		 3fi0G-3q4gA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		4 / 7 LYS A 203
ALA A 202
THR A  52
VAL A  48
 None
 0.96A 3ozkB-3q4gA:
undetectable		 3ozkB-3q4gA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		4 / 7 LEU A 244
LYS A 247
VAL A 249
LEU A 257
 None
 1.11A 4b3qA-3q4gA:
undetectable		 4b3qA-3q4gA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		3 / 3 ARG A  24
ASP A  49
ASP A 182
 None
CA  A 279 (-4.9A)
None
 0.87A 4kicB-3q4gA:
undetectable		 4kicB-3q4gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Vibrio
cholerae) 		5 / 12 ASP A 167
ASP A 241
LEU A 244
ILE A 240
ASP A  49
 None
None
None
None
CA  A 279 (-4.9A)
 1.25A 5nn8A-3q4gA:
undetectable		 5nn8A-3q4gA:
16.88