SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.70A 1iepA-3q4tA:
23.9		 1iepA-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.73A 1iepB-3q4tA:
24.0		 1iepB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 11 LEU A 394
ALA A 301
ALA A 297
MET A 296
LEU A 275
 None
 1.13A 1iiuA-3q4tA:
undetectable		 1iiuA-3q4tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.78A 1opjB-3q4tA:
23.7		 1opjB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.82A 1uwhA-3q4tA:
25.3		 1uwhA-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 VAL A 206
VAL A 235
ILE A 246
ILE A 318
 TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
None
None
 0.55A 1uwhA-3q4tA:
25.3		 1uwhA-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
LYS A 219
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.93A 1uwhB-3q4tA:
25.2		 1uwhB-3q4tA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.86A 1uwjA-3q4tA:
6.9		 1uwjA-3q4tA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.85A 1uwjB-3q4tA:
24.3		 1uwjB-3q4tA:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
GLY A 273
LEU A 329
ASP A 340
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
None
 0.88A 1xkkA-3q4tA:
24.6		 1xkkA-3q4tA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 5 ARG A 379
PHE A 347
LEU A 303
ALA A 317
 None
 1.35A 2e1qD-3q4tA:
undetectable		 2e1qD-3q4tA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.54A 2gqgA-3q4tA:
26.4		 2gqgA-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.56A 2hyyA-3q4tA:
24.5		 2hyyA-3q4tA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.69A 2hyyB-3q4tA:
24.4		 2hyyB-3q4tA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.61A 2hyyC-3q4tA:
24.4		 2hyyC-3q4tA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
GLU A 232
LEU A 265
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.73A 2itoA-3q4tA:
25.6		 2itoA-3q4tA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 VAL A 206
ALA A 217
LYS A 219
GLU A 232
GLY A 273
ASP A 277
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.0A)
TAK  A   2 (-4.6A)
None
 1.01A 2itzA-3q4tA:
25.4		 2itzA-3q4tA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
LYS A 219
GLU A 232
THR A 267
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.59A 2zvaA-3q4tA:
26.7		 2zvaA-3q4tA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 VAL A 206
ALA A 217
LEU A 265
THR A 267
GLY A 273
LEU A 329
ASP A 340
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
None
 1.00A 3bbtD-3q4tA:
24.0		 3bbtD-3q4tA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		3 / 3 MET A 482
VAL A 475
GLU A 456
 None
 0.88A 3c6gA-3q4tA:
undetectable		 3c6gA-3q4tA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
GLY A 273
HIS A 320
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.44A 3cs9A-3q4tA:
24.1		 3cs9A-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
VAL A 235
THR A 267
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.62A 3cs9A-3q4tA:
24.1		 3cs9A-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
THR A 267
GLY A 273
HIS A 320
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 ( 4.2A)
 0.52A 3cs9B-3q4tA:
24.2		 3cs9B-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
VAL A 235
THR A 267
GLY A 273
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.53A 3cs9B-3q4tA:
24.2		 3cs9B-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
GLU A 232
VAL A 235
THR A 267
PHE A 269
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
 0.74A 3cs9C-3q4tA:
23.9		 3cs9C-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
THR A 267
PHE A 269
HIS A 320
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
None
TAK  A   2 ( 4.2A)
 0.49A 3cs9C-3q4tA:
23.9		 3cs9C-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
VAL A 235
THR A 267
PHE A 269
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 ( 4.2A)
 0.60A 3cs9C-3q4tA:
23.9		 3cs9C-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
GLU A 232
VAL A 235
THR A 267
PHE A 269
GLY A 273
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
 0.68A 3cs9D-3q4tA:
23.2		 3cs9D-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
HIS A 320
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
None
TAK  A   2 ( 4.2A)
 0.49A 3cs9D-3q4tA:
23.2		 3cs9D-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
VAL A 235
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 (-3.5A)
EDO  A 489 ( 4.8A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.62A 3cs9D-3q4tA:
23.2		 3cs9D-3q4tA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 GLY A 201
GLY A 204
VAL A 206
ALA A 217
SER A 274
ASN A 327
LEU A 329
ASP A 340
 None
None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
None
TAK  A   2 (-4.6A)
None
 0.68A 3eygA-3q4tA:
27.8		 3eygA-3q4tA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
THR A 267
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.56A 3g5dA-3q4tA:
25.8		 3g5dA-3q4tA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 MET A 241
ILE A 318
HIS A 320
ILE A 338
 None
 0.58A 3hegA-3q4tA:
17.7		 3hegA-3q4tA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.84A 3k5vA-3q4tA:
23.7		 3k5vA-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.67A 3k5vA-3q4tA:
23.7		 3k5vA-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.87A 3k5vB-3q4tA:
23.7		 3k5vB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.67A 3k5vB-3q4tA:
23.7		 3k5vB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 9 ALA A 217
LYS A 219
PHE A 269
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.71A 3miyB-3q4tA:
25.1		 3miyB-3q4tA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.73A 3ms9A-3q4tA:
23.9		 3ms9A-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.69A 3ms9B-3q4tA:
23.9		 3ms9B-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.73A 3mssA-3q4tA:
24.0		 3mssA-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.35A 3mssB-3q4tA:
23.9		 3mssB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.72A 3mssC-3q4tA:
24.0		 3mssC-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.36A 3mssD-3q4tA:
23.9		 3mssD-3q4tA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.82A 3og7A-3q4tA:
25.1		 3og7A-3q4tA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.40A 3pyyA-3q4tA:
23.7		 3pyyA-3q4tA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 ALA A 217
LYS A 219
THR A 267
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.02A 3zosA-3q4tA:
22.9		 3zosA-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 ALA A 217
LYS A 219
GLU A 232
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.20A 3zosB-3q4tA:
23.1		 3zosB-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		8 / 12 ALA A 217
LYS A 219
THR A 267
LEU A 303
HIS A 320
ARG A 321
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
None
None
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 1.02A 3zosB-3q4tA:
23.1		 3zosB-3q4tA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 11 ALA A 217
LYS A 219
PHE A 269
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.53A 4agdA-3q4tA:
23.4		 4agdA-3q4tA:
24.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
LYS A 219
GLU A 232
LEU A 247
THR A 267
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.71A 4c8bA-3q4tA:
24.0		 4c8bA-3q4tA:
32.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
LYS A 219
LEU A 247
THR A 267
HIS A 320
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.57A 4c8bA-3q4tA:
24.0		 4c8bA-3q4tA:
32.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
ILE A 246
LEU A 247
THR A 267
HIS A 320
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
None
None
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.52A 4c8bB-3q4tA:
24.6		 4c8bB-3q4tA:
32.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 11 GLY A 201
VAL A 206
ALA A 217
GLY A 273
SER A 274
LEU A 329
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
 0.48A 4ckiA-3q4tA:
28.0		 4ckiA-3q4tA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 11 ALA A 472
LEU A 383
PHE A 341
VAL A 235
ILE A 246
 None
None
None
EDO  A 489 ( 4.8A)
None
 1.40A 4claA-3q4tA:
undetectable		 4claA-3q4tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 VAL A 370
ARG A 321
PHE A 382
GLU A 369
 None
 1.43A 4d33A-3q4tA:
undetectable
4d33B-3q4tA:
undetectable		 4d33A-3q4tA:
23.32
4d33B-3q4tA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 PHE A 382
GLU A 369
VAL A 370
ARG A 321
 None
 1.43A 4d33A-3q4tA:
undetectable
4d33B-3q4tA:
undetectable		 4d33A-3q4tA:
23.32
4d33B-3q4tA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 PHE A 382
GLU A 369
VAL A 370
ARG A 321
 None
 1.45A 4d35A-3q4tA:
undetectable
4d35B-3q4tA:
undetectable		 4d35A-3q4tA:
23.32
4d35B-3q4tA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 PHE A 377
ALA A 381
ALA A 367
PRO A 368
 None
 1.00A 4dtzA-3q4tA:
undetectable		 4dtzA-3q4tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 PHE A 377
ALA A 381
ALA A 367
PRO A 368
 None
 1.01A 4dtzB-3q4tA:
undetectable		 4dtzB-3q4tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ASP A 322
ASP A 340
ARG A 202
GLU A 396
SER A 276
 None
None
SO4  A   4 (-3.8A)
None
None
 1.49A 4feuA-3q4tA:
10.0
4feuB-3q4tA:
8.0		 4feuA-3q4tA:
22.48
4feuB-3q4tA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
THR A 267
GLY A 273
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.57A 4hjoA-3q4tA:
24.5		 4hjoA-3q4tA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
ASP A 322
LYS A 324
ASN A 327
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
EDO  A  18 (-3.0A)
None
TAK  A   2 (-4.6A)
None
 0.71A 4i41A-3q4tA:
23.4		 4i41A-3q4tA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 5 GLN A 248
THR A 267
HIS A 320
LEU A 303
 None
TAK  A   2 (-3.5A)
None
None
 1.34A 4lvcC-3q4tA:
undetectable		 4lvcC-3q4tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 GLY A 201
VAL A 206
ALA A 217
LYS A 219
GLY A 273
LEU A 329
ASP A 340
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.80A 4mkcA-3q4tA:
25.3		 4mkcA-3q4tA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 6 VAL A 206
ALA A 217
LYS A 219
LEU A 247
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-4.6A)
 0.71A 4o0uA-3q4tA:
7.2		 4o0uA-3q4tA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 8 GLY A 201
VAL A 206
ALA A 217
ASN A 327
LEU A 329
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
 0.61A 4ogrA-3q4tA:
26.0		 4ogrA-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 8 VAL A 206
ALA A 217
ASN A 327
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
None
 0.41A 4ogrA-3q4tA:
26.0		 4ogrA-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 7 ALA A 217
ASN A 327
LEU A 329
ASP A 340
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
None
 0.26A 4ogrE-3q4tA:
24.9		 4ogrE-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 9 GLY A 201
VAL A 206
ALA A 217
ASN A 327
LEU A 329
ASP A 340
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
None
 0.67A 4ogrI-3q4tA:
26.4		 4ogrI-3q4tA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
GLU A 232
LEU A 303
ARG A 321
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
None
TAK  A   2 ( 4.2A)
 1.12A 4qrcA-3q4tA:
24.7		 4qrcA-3q4tA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
GLU A 232
THR A 267
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.6A)
 0.67A 4r7iA-3q4tA:
23.9		 4r7iA-3q4tA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
LEU A 247
THR A 267
SER A 274
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.96A 4rzvA-3q4tA:
25.4		 4rzvA-3q4tA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
SER A 274
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.97A 4rzvB-3q4tA:
25.4		 4rzvB-3q4tA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
THR A 267
GLY A 273
HIS A 320
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
 0.60A 4u0iA-3q4tA:
24.1		 4u0iA-3q4tA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
GLU A 232
LEU A 303
HIS A 320
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
None
TAK  A   2 ( 4.2A)
 1.01A 4v04A-3q4tA:
23.6		 4v04A-3q4tA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 11 ALA A 217
THR A 267
GLY A 273
ASN A 327
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.57A 4wa9A-3q4tA:
23.4		 4wa9A-3q4tA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 ALA A 217
THR A 267
PHE A 269
GLY A 273
ASN A 327
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.65A 4wa9B-3q4tA:
25.5		 4wa9B-3q4tA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
GLY A 273
ASN A 327
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.70A 4wa9B-3q4tA:
25.5		 4wa9B-3q4tA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 LEU A 275
ALA A 336
LYS A 331
LEU A 334
ASN A 333
 None
None
None
None
EDO  A  19 (-3.5A)
 1.26A 4x1kA-3q4tA:
undetectable
4x1kB-3q4tA:
undetectable		 4x1kA-3q4tA:
21.00
4x1kB-3q4tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LYS A 219
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.68A 4xeyA-3q4tA:
26.2		 4xeyA-3q4tA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.55A 4xeyA-3q4tA:
26.2		 4xeyA-3q4tA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
THR A 267
PHE A 269
GLY A 273
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.55A 4xeyB-3q4tA:
26.1		 4xeyB-3q4tA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		3 / 3 ASP A 225
LEU A 343
GLY A 342
 None
 0.55A 4xmfA-3q4tA:
undetectable		 4xmfA-3q4tA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
ASP A 340
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.86A 4xv2A-3q4tA:
25.2		 4xv2A-3q4tA:
30.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
LEU A 247
THR A 267
ASP A 340
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.79A 4xv2B-3q4tA:
25.5		 4xv2B-3q4tA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
PHE A 269
GLY A 273
LEU A 329
ALA A 339
ASP A 340
 TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
None
 0.69A 5ajqA-3q4tA:
22.2		 5ajqA-3q4tA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.63A 5cswA-3q4tA:
25.3		 5cswA-3q4tA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.64A 5cswB-3q4tA:
24.8		 5cswB-3q4tA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		3 / 3 MET A 482
GLN A 481
ARG A 484
 None
 1.02A 5ewzB-3q4tA:
undetectable		 5ewzB-3q4tA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.63A 5h2uA-3q4tA:
24.9		 5h2uA-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.69A 5h2uB-3q4tA:
25.1		 5h2uB-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
LEU A 247
THR A 267
GLY A 273
ASP A 340
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
 0.56A 5h2uC-3q4tA:
24.9		 5h2uC-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.56A 5h2uC-3q4tA:
24.9		 5h2uC-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LEU A 247
THR A 267
GLY A 273
LEU A 329
ASP A 340
 TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
 0.54A 5h2uD-3q4tA:
25.1		 5h2uD-3q4tA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 LYS A 219
PHE A 249
SER A 274
ASP A 340
 TAK  A   2 (-2.9A)
None
None
None
 0.95A 5hesA-3q4tA:
8.6		 5hesA-3q4tA:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
LEU A 247
THR A 267
LEU A 303
HIS A 320
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.86A 5hi2A-3q4tA:
25.1		 5hi2A-3q4tA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.57A 5hieA-3q4tA:
25.7		 5hieA-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 0.55A 5hieA-3q4tA:
25.7		 5hieA-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.58A 5hieB-3q4tA:
25.7		 5hieB-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 0.56A 5hieB-3q4tA:
25.7		 5hieB-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.57A 5hieC-3q4tA:
25.9		 5hieC-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 GLY A 201
VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 1.49A 5hieC-3q4tA:
25.9		 5hieC-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
ASP A 340
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
 0.82A 5hieC-3q4tA:
25.9		 5hieC-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 GLY A 201
VAL A 206
ALA A 217
LEU A 247
THR A 267
 None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
 0.59A 5hieD-3q4tA:
25.7		 5hieD-3q4tA:
30.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		5 / 12 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
 0.55A 5hieD-3q4tA:
25.7		 5hieD-3q4tA:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		6 / 12 ALA A 217
LYS A 219
GLU A 232
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.60A 5i9yA-3q4tA:
24.4		 5i9yA-3q4tA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		3 / 3 MET A 482
GLN A 481
ARG A 484
 None
 1.03A 5m35B-3q4tA:
undetectable		 5m35B-3q4tA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		3 / 3 MET A 482
GLN A 481
ARG A 484
 None
 1.05A 5m36A-3q4tA:
undetectable		 5m36A-3q4tA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 7 ARG A 363
ARG A 202
ASP A 322
SER A 276
 SO4  A   4 (-4.1A)
SO4  A   4 (-3.8A)
None
None
 1.29A 5uxcA-3q4tA:
3.9		 5uxcA-3q4tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 7 VAL A 370
ARG A 321
PHE A 382
GLU A 369
 None
 1.40A 5vvaA-3q4tA:
undetectable
5vvaB-3q4tA:
undetectable		 5vvaA-3q4tA:
23.32
5vvaB-3q4tA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 GLN A 227
PHE A 203
PHE A 221
LEU A 265
 None
 1.11A 5zcoP-3q4tA:
2.9
5zcoW-3q4tA:
undetectable		 5zcoP-3q4tA:
19.57
5zcoW-3q4tA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 GLN A 227
PHE A 203
PHE A 221
LEU A 265
 None
 1.11A 5zcpC-3q4tA:
2.5
5zcpJ-3q4tA:
undetectable		 5zcpC-3q4tA:
19.57
5zcpJ-3q4tA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 7 PHE A 382
GLU A 369
VAL A 370
ARG A 321
 None
 1.45A 6cieA-3q4tA:
undetectable
6cieB-3q4tA:
undetectable		 6cieA-3q4tA:
10.29
6cieB-3q4tA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 6 VAL A 370
ARG A 321
PHE A 382
GLU A 369
 None
 1.47A 6cieC-3q4tA:
undetectable
6cieD-3q4tA:
0.0		 6cieC-3q4tA:
10.29
6cieD-3q4tA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		4 / 7 VAL A 370
ARG A 321
PHE A 382
GLU A 369
 None
 1.36A 6cifC-3q4tA:
undetectable
6cifD-3q4tA:
0.0		 6cifC-3q4tA:
10.29
6cifD-3q4tA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		3 / 3 MET A 482
GLN A 481
ARG A 484
 None
 1.06A 6fn9A-3q4tA:
undetectable		 6fn9A-3q4tA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		3 / 3 MET A 482
GLN A 481
ARG A 484
 None
 1.06A 6fnaB-3q4tA:
undetectable		 6fnaB-3q4tA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		3 / 3 MET A 482
GLN A 481
ARG A 484
 None
 1.05A 6fnbA-3q4tA:
undetectable		 6fnbA-3q4tA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
LYS A 219
GLU A 232
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.76A 6fnmA-3q4tA:
25.5		 6fnmA-3q4tA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens) 		7 / 12 VAL A 206
ALA A 217
GLU A 232
THR A 267
PHE A 269
LEU A 329
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.88A 6hd6A-3q4tA:
23.7		 6hd6A-3q4tA:
15.41