SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 9 GLU A 148
ARG A 123
ILE A 101
ALA A  99
ILE A  70
 PEG  A 234 ( 4.4A)
PEG  A 234 (-3.9A)
None
None
None
 1.45A 1aj6A-3q58A:
undetectable		 1aj6A-3q58A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 GLY A  98
ALA A  99
ASP A 100
ILE A  70
THR A  85
 PEG  A 239 ( 4.2A)
None
PEG  A 241 ( 3.4A)
None
None
 0.94A 1c6yB-3q58A:
undetectable		 1c6yB-3q58A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		3 / 3 ARG A  51
GLY A 151
ASP A 132
 None
 0.45A 1kf6A-3q58A:
undetectable
1kf6B-3q58A:
undetectable		 1kf6A-3q58A:
16.15
1kf6B-3q58A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 LEU A  88
LEU A  94
ALA A  95
LEU A 127
LEU A 119
 None
 1.00A 1s9pB-3q58A:
undetectable		 1s9pB-3q58A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		4 / 7 SER A   2
ARG A 123
LEU A 128
GLU A 148
 PEG  A 241 ( 3.8A)
PEG  A 234 (-3.9A)
None
PEG  A 234 ( 4.4A)
 1.07A 2cdqB-3q58A:
undetectable		 2cdqB-3q58A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 11 GLY A  98
ALA A  99
GLY A  54
THR A  85
ILE A 102
 PEG  A 239 ( 4.2A)
None
None
None
None
 0.89A 3ekxA-3q58A:
undetectable		 3ekxA-3q58A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 9 GLY A  98
ALA A  99
ASP A 100
ILE A 101
LEU A  94
 PEG  A 239 ( 4.2A)
None
PEG  A 241 ( 3.4A)
None
None
 0.73A 3ogpA-3q58A:
undetectable		 3ogpA-3q58A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 9 GLY A  98
ALA A  99
ASP A 100
ILE A 101
LEU A  94
 PEG  A 239 ( 4.2A)
None
PEG  A 241 ( 3.4A)
None
None
 0.79A 3ogpB-3q58A:
undetectable		 3ogpB-3q58A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 GLY A  98
ALA A  99
ASP A 100
ILE A 101
LEU A  94
 PEG  A 239 ( 4.2A)
None
PEG  A 241 ( 3.4A)
None
None
 0.77A 3ogqB-3q58A:
undetectable		 3ogqB-3q58A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 THR A 153
GLY A 185
GLY A 207
MET A 170
GLU A 138
 None
PEG  A 231 ( 4.0A)
None
None
None
 1.17A 3tkaA-3q58A:
undetectable		 3tkaA-3q58A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 GLY A 151
ALA A 131
ILE A 182
LEU A 154
SER A 134
 None
None
None
PEG  A 230 (-4.9A)
None
 0.89A 4azvA-3q58A:
undetectable		 4azvA-3q58A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		3 / 3 GLY A 207
SER A 208
TRP A 219
 None
PEG  A 231 (-3.2A)
PEG  A 232 (-3.6A)
 0.98A 4e7cD-3q58A:
undetectable		 4e7cD-3q58A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 ARG A 121
GLY A  98
ALA A  99
GLY A  54
ILE A 102
 None
PEG  A 239 ( 4.2A)
None
None
None
 1.07A 4njvA-3q58A:
undetectable		 4njvA-3q58A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 ALA A 103
GLY A 151
ILE A  70
ILE A 182
ILE A 147
 None
 1.03A 4q5mA-3q58A:
undetectable		 4q5mA-3q58A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 LEU A 174
GLY A 200
ALA A 201
ILE A 182
ILE A 150
 None
 0.97A 4xdrA-3q58A:
undetectable		 4xdrA-3q58A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		4 / 6 ARG A  51
GLY A 207
THR A 153
GLU A 184
 None
 1.07A 5btaA-3q58A:
undetectable
5btaB-3q58A:
undetectable
5btaC-3q58A:
undetectable		 5btaA-3q58A:
21.00
5btaB-3q58A:
23.77
5btaC-3q58A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		4 / 6 ARG A  51
GLY A 207
THR A 153
GLU A 184
 None
 1.10A 5btcA-3q58A:
undetectable
5btcC-3q58A:
undetectable
5btcD-3q58A:
undetectable		 5btcA-3q58A:
21.00
5btcC-3q58A:
21.00
5btcD-3q58A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		4 / 6 ARG A  51
GLY A 207
THR A 153
GLU A 184
 None
 1.07A 5btcA-3q58A:
undetectable
5btcB-3q58A:
undetectable
5btcC-3q58A:
undetectable		 5btcA-3q58A:
21.00
5btcB-3q58A:
23.77
5btcC-3q58A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		4 / 7 ILE A 147
ILE A 182
ILE A  70
PHE A 104
 None
 0.83A 5fukA-3q58A:
undetectable
5fukB-3q58A:
undetectable		 5fukA-3q58A:
22.48
5fukB-3q58A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 ILE A 150
GLY A 151
THR A 153
ALA A 131
PHE A 108
 None
 1.22A 5hw4A-3q58A:
undetectable		 5hw4A-3q58A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 ILE A 150
GLY A 151
THR A 153
ALA A 131
PHE A 108
 None
 1.20A 5hw4C-3q58A:
undetectable		 5hw4C-3q58A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		4 / 6 PHE A 104
PRO A  86
ARG A 111
ILE A  84
 None
 1.35A 5ih0A-3q58A:
undetectable		 5ih0A-3q58A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		5 / 12 LEU A   3
ILE A 101
THR A 205
ALA A  47
GLY A  15
 PEG  A 241 (-4.2A)
None
None
None
None
 1.04A 5veuA-3q58A:
undetectable		 5veuA-3q58A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Salmonella
enterica) 		3 / 3 ASP A 132
LEU A 154
ARG A 186
 None
PEG  A 230 (-4.9A)
None
 0.67A 7dfrA-3q58A:
undetectable		 7dfrA-3q58A:
22.55