SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 151
ASN A 195
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.1A)
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.71A 1fmoE-3q5iA:
28.2		 1fmoE-3q5iA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.85A 1iepA-3q5iA:
20.1		 1iepA-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
 0.77A 1iepB-3q5iA:
20.0		 1iepB-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
MG  A 529 (-2.2A)
 0.84A 1m17A-3q5iA:
23.8		 1m17A-3q5iA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
 0.87A 1opjB-3q5iA:
20.0		 1opjB-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 12 LEU A 197
LEU A 198
GLY A 149
THR A 144
ILE A 128
 ANP  A1634 (-4.4A)
None
None
ANP  A1634 (-4.6A)
None
 1.37A 1p93A-3q5iA:
undetectable		 1p93A-3q5iA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 5 ILE A 301
TRP A 290
LEU A 305
PRO A 265
 None
 1.24A 1s8fA-3q5iA:
undetectable
1s8fB-3q5iA:
undetectable		 1s8fA-3q5iA:
16.50
1s8fB-3q5iA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
LEU A 119
THR A 144
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
 0.86A 1t46A-3q5iA:
19.9		 1t46A-3q5iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
LEU A 119
THR A 144
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.75A 1t46A-3q5iA:
19.9		 1t46A-3q5iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 ALA A  84
GLU A 115
LEU A 119
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.6A)
None
None
 0.65A 1uwhA-3q5iA:
21.5		 1uwhA-3q5iA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 ALA A  84
LYS A  86
GLU A 115
LEU A 119
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
None
 0.72A 1uwhB-3q5iA:
21.4		 1uwhB-3q5iA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
None
None
 0.68A 1uwjA-3q5iA:
7.2		 1uwjA-3q5iA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
None
None
 0.67A 1uwjB-3q5iA:
7.2		 1uwjB-3q5iA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 9 LEU A  63
VAL A  71
LYS A  86
LEU A 130
LEU A 142
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
None
None
 0.68A 1xkkA-3q5iA:
21.2		 1xkkA-3q5iA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 9 LEU A 118
LEU A 119
LEU A 181
ILE A 186
TYR A 180
 None
 1.16A 2f78B-3q5iA:
undetectable		 2f78B-3q5iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 9 LEU A 118
LEU A 119
LEU A 181
ILE A 186
TYR A 180
 None
 1.22A 2f7aB-3q5iA:
undetectable		 2f7aB-3q5iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
ASP A 190
LYS A 192
ASN A 195
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
CA  A 528 ( 3.0A)
MG  A 529 (-2.2A)
 0.69A 2fumA-3q5iA:
24.9		 2fumA-3q5iA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.85A 2hyyA-3q5iA:
20.1		 2hyyA-3q5iA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.85A 2hyyB-3q5iA:
20.3		 2hyyB-3q5iA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.70A 2hyyC-3q5iA:
20.3		 2hyyC-3q5iA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
ANP  A1634 (-4.4A)
 0.79A 2hyyD-3q5iA:
20.1		 2hyyD-3q5iA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 LEU A  63
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.73A 2itoA-3q5iA:
23.1		 2itoA-3q5iA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
GLY A  64
VAL A  71
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.71A 2ityA-3q5iA:
23.0		 2ityA-3q5iA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		3 / 3 LEU A 204
ASN A 202
ARG A 159
 None
 0.86A 2qhfA-3q5iA:
undetectable		 2qhfA-3q5iA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 4 ARG A  47
PHE A 131
LEU A 462
PHE A 463
 None
 1.40A 3ag1P-3q5iA:
2.2
3ag1W-3q5iA:
0.0		 3ag1P-3q5iA:
17.23
3ag1W-3q5iA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
GLY A  64
ALA A  84
LYS A  86
VAL A 210
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 1.12A 3c7qA-3q5iA:
19.4		 3c7qA-3q5iA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 12 ALA A  84
GLU A 115
THR A 144
PHE A 146
HIS A 188
 ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
 0.78A 3cs9C-3q5iA:
19.9		 3cs9C-3q5iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 12 ALA A  84
LEU A 122
THR A 144
PHE A 146
HIS A 188
 ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
 0.89A 3cs9C-3q5iA:
19.9		 3cs9C-3q5iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 6 LEU A  63
VAL A  71
LYS A  86
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.4A)
 0.78A 3cs9D-3q5iA:
19.0		 3cs9D-3q5iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 11 LEU A  63
VAL A  71
ALA A  84
THR A 144
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.39A 3g0eA-3q5iA:
19.7		 3g0eA-3q5iA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 11 LEU A  63
VAL A  71
ALA A  84
THR A 144
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.34A 3g0fA-3q5iA:
20.0		 3g0fA-3q5iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 10 LEU A  63
VAL A  71
ALA A  84
THR A 144
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.41A 3g0fB-3q5iA:
20.1		 3g0fB-3q5iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 12 ALA A  84
LEU A 119
ILE A 128
THR A 144
HIS A 188
 ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.6A)
None
 0.93A 3gcsA-3q5iA:
22.0		 3gcsA-3q5iA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
GLU A 115
LEU A 119
ILE A 128
THR A 144
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.6A)
 0.99A 3gcsA-3q5iA:
22.0		 3gcsA-3q5iA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 ALA A  84
GLU A 115
LEU A 119
ILE A 128
THR A 144
HIS A 188
ASP A 211
 ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.6A)
None
MG  A 529 (-2.2A)
 1.19A 3gp0A-3q5iA:
22.5		 3gp0A-3q5iA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 VAL A  71
ALA A  84
GLU A 115
LEU A 118
LEU A 119
ILE A 128
THR A 144
HIS A 188
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
None
ANP  A1634 (-4.6A)
None
 0.65A 3gp0A-3q5iA:
22.5		 3gp0A-3q5iA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		3 / 3 GLY A 281
PRO A 265
LEU A 305
 None
 0.46A 3hcpB-3q5iA:
undetectable		 3hcpB-3q5iA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 ALA A  84
LYS A  86
GLU A 115
LEU A 118
LEU A 119
ILE A 128
THR A 144
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
None
None
ANP  A1634 (-4.6A)
 0.78A 3hecA-3q5iA:
22.4		 3hecA-3q5iA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
LYS A  86
GLU A 115
LEU A 119
ILE A 128
THR A 144
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
None
ANP  A1634 (-4.6A)
 0.94A 3hegA-3q5iA:
12.8		 3hegA-3q5iA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.85A 3k5vA-3q5iA:
17.2		 3k5vA-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.83A 3k5vB-3q5iA:
19.9		 3k5vB-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 8 ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.63A 3lfaA-3q5iA:
22.3		 3lfaA-3q5iA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
ANP  A1634 (-4.4A)
 0.79A 3ms9A-3q5iA:
19.8		 3ms9A-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.81A 3ms9B-3q5iA:
20.0		 3ms9B-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
ANP  A1634 (-4.4A)
 0.82A 3mssA-3q5iA:
20.0		 3mssA-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
ANP  A1634 (-4.4A)
 0.81A 3mssC-3q5iA:
19.9		 3mssC-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.88A 3mssD-3q5iA:
20.0		 3mssD-3q5iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 5 ILE A 441
THR A 369
GLU A 199
GLU A 371
 None
 1.29A 3ny4A-3q5iA:
undetectable		 3ny4A-3q5iA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
LYS A  86
LEU A 119
THR A 144
PHE A 212
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
 0.90A 3og7A-3q5iA:
21.6		 3og7A-3q5iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 GLY A  64
VAL A  71
ALA A  84
LEU A 119
ILE A 128
THR A 144
 ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.6A)
 0.48A 3ohtA-3q5iA:
17.9		 3ohtA-3q5iA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 GLY A  64
VAL A  71
ALA A  84
LYS A  86
LEU A 119
THR A 144
 ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
 0.74A 3ohtA-3q5iA:
17.9		 3ohtA-3q5iA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 GLY A  64
VAL A  71
ALA A  84
LEU A 119
ILE A 128
THR A 144
 ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.6A)
 0.46A 3ohtB-3q5iA:
3.9		 3ohtB-3q5iA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
ANP  A1634 (-4.4A)
 0.86A 3pyyA-3q5iA:
20.2		 3pyyA-3q5iA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.4A)
 0.74A 3pyyB-3q5iA:
20.1		 3pyyB-3q5iA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
GLU A 115
LEU A 119
ILE A 128
LEU A 181
HIS A 188
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
None
None
 0.63A 3rgfA-3q5iA:
21.8		 3rgfA-3q5iA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 11 LEU A 152
GLY A 177
ILE A 178
ILE A 170
ILE A 207
 None
 1.03A 3s53B-3q5iA:
undetectable		 3s53B-3q5iA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 9 LEU A 152
GLY A 177
ILE A 178
ILE A 170
ILE A 207
 None
 1.07A 3s56B-3q5iA:
undetectable		 3s56B-3q5iA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
ALA A  84
LYS A  86
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.98A 3ue4A-3q5iA:
22.7		 3ue4A-3q5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.90A 3ue4B-3q5iA:
22.7		 3ue4B-3q5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 8 VAL A  71
LYS A  86
ILE A 128
ASP A 211
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
None
MG  A 529 (-2.2A)
 0.68A 3warA-3q5iA:
25.7		 3warA-3q5iA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 12 LEU A  63
VAL A  71
ALA A  84
LEU A 119
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
 0.54A 3wzdA-3q5iA:
19.7		 3wzdA-3q5iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
LEU A 119
PHE A 146
LEU A 181
HIS A 188
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.8A)
None
None
 0.51A 3wzeA-3q5iA:
20.0		 3wzeA-3q5iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
LYS A  86
LEU A 119
PHE A 146
GLY A 150
LEU A 181
HIS A 188
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.8A)
None
None
None
 0.68A 3wzeA-3q5iA:
20.0		 3wzeA-3q5iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		9 / 12 LEU A  63
ALA A  84
LYS A  86
GLU A 115
THR A 144
LEU A 181
HIS A 188
ARG A 189
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
None
None
ANP  A1634 (-4.4A)
 0.75A 3zosA-3q5iA:
20.4		 3zosA-3q5iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		9 / 12 ALA A  84
LYS A  86
GLU A 115
ILE A 128
THR A 144
LEU A 181
HIS A 188
ARG A 189
LEU A 197
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
None
None
ANP  A1634 (-4.4A)
 0.79A 3zosB-3q5iA:
20.7		 3zosB-3q5iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		9 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
VAL A 210
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 1.35A 4ag8A-3q5iA:
19.9		 4ag8A-3q5iA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
LEU A 119
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
 0.55A 4agcA-3q5iA:
19.6		 4agcA-3q5iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 11 LEU A  63
ALA A  84
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.55A 4agdA-3q5iA:
19.2		 4agdA-3q5iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		10 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
LEU A 119
PHE A 146
GLY A 150
LEU A 181
HIS A 188
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.8A)
None
None
None
 0.72A 4asdA-3q5iA:
19.9		 4asdA-3q5iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 ALA A  84
LYS A  86
GLU A 115
ILE A 127
THR A 144
HIS A 188
LEU A 197
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.79A 4c8bB-3q5iA:
21.3		 4c8bB-3q5iA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 ALA A  84
LYS A  86
GLU A 115
LEU A 119
THR A 144
HIS A 188
LEU A 197
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.92A 4c8bB-3q5iA:
21.3		 4c8bB-3q5iA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
ASP A 190
LYS A 192
ASN A 195
LEU A 197
ASP A 211
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.45A 4i41A-3q5iA:
25.0		 4i41A-3q5iA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 11 VAL A  71
ALA A  84
LYS A  86
LEU A 197
ASP A 211
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.62A 4iaaA-3q5iA:
24.8		 4iaaA-3q5iA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 GLY A  64
VAL A  71
ALA A  84
LEU A 130
LEU A 142
GLY A 150
GLU A 151
LEU A 197
 ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.1A)
ANP  A1634 (-4.4A)
 0.42A 4ifgA-3q5iA:
26.2		 4ifgA-3q5iA:
50.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.69A 4mkcA-3q5iA:
22.0		 4mkcA-3q5iA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 11 LEU A  63
GLY A  64
VAL A  71
ALA A  84
LYS A  86
ASN A 195
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
CA  A 528 ( 3.0A)
MG  A 529 (-2.2A)
 0.84A 4o0sA-3q5iA:
27.3		 4o0sA-3q5iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 11 LEU A  63
GLY A  64
VAL A  71
ALA A  84
LYS A  86
ASN A 195
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
 0.62A 4o0sA-3q5iA:
27.3		 4o0sA-3q5iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 6 LEU A  63
GLY A  64
VAL A  71
ALA A  84
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.4A)
 0.50A 4o0wA-3q5iA:
26.2		 4o0wA-3q5iA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 8 VAL A  71
ALA A  84
ASN A 195
LEU A 197
ASP A 211
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.63A 4ogrA-3q5iA:
25.1		 4ogrA-3q5iA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
LYS A  86
THR A 144
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 1.09A 4otwA-3q5iA:
19.9		 4otwA-3q5iA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		3 / 3 ASP A 502
ASP A 498
ASN A 491
 CA  A 526 (-2.9A)
CA  A 526 (-3.1A)
None
 0.82A 4q5mA-3q5iA:
undetectable		 4q5mA-3q5iA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
LYS A  86
GLU A 115
THR A 144
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.4A)
 0.63A 4r7iA-3q5iA:
19.6		 4r7iA-3q5iA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 8 PHE A 463
ILE A 471
LEU A 476
MET A 513
 None
 0.68A 4rjdA-3q5iA:
8.4		 4rjdA-3q5iA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 7 PHE A 463
ALA A 497
MET A 513
MET A 514
 None
 0.87A 4rjdB-3q5iA:
8.3		 4rjdB-3q5iA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 7 PHE A 463
LEU A 476
MET A 513
MET A 514
 None
 0.75A 4rjdB-3q5iA:
8.3		 4rjdB-3q5iA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		9 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
PHE A 146
GLY A 150
ASN A 195
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.8A)
None
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.60A 4twpA-3q5iA:
23.0		 4twpA-3q5iA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
PHE A 146
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.68A 4twpB-3q5iA:
22.9		 4twpB-3q5iA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
PHE A 146
GLY A 150
ASN A 195
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.8A)
None
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.68A 4twpB-3q5iA:
22.9		 4twpB-3q5iA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 6 LEU A  63
VAL A  71
ILE A 127
ILE A 209
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
None
None
 0.43A 4tyjA-3q5iA:
20.2		 4tyjA-3q5iA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 ALA A  84
LYS A  86
LEU A 119
THR A 144
GLY A 150
HIS A 188
LEU A 197
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
None
ANP  A1634 (-4.4A)
 0.82A 4u0iA-3q5iA:
20.0		 4u0iA-3q5iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LYS A  86
LEU A 119
THR A 144
GLY A 150
HIS A 188
LEU A 197
ASP A 211
 ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 1.16A 4u0iA-3q5iA:
20.0		 4u0iA-3q5iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 7 VAL A  71
ILE A 128
ARG A 189
ILE A 209
 ANP  A1634 (-4.1A)
None
None
None
 0.64A 4uxqA-3q5iA:
20.0		 4uxqA-3q5iA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 11 LEU A  63
ALA A  84
THR A 144
GLY A 150
ASN A 195
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.6A)
None
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
 1.06A 4wa9A-3q5iA:
19.1		 4wa9A-3q5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
LYS A  86
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.68A 4wa9B-3q5iA:
22.2		 4wa9B-3q5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 VAL A  71
ALA A  84
THR A 144
PHE A 146
GLY A 150
ASN A 195
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
 0.69A 4wa9B-3q5iA:
22.2		 4wa9B-3q5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 6 ARG A  61
LEU A  63
ALA A  84
LEU A 197
 None
ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.4A)
 0.84A 4wboC-3q5iA:
23.8		 4wboC-3q5iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
THR A 144
PHE A 146
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.94A 4xeyA-3q5iA:
22.6		 4xeyA-3q5iA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
LYS A  86
THR A 144
ASP A 211
PHE A 212
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.6A)
MG  A 529 (-2.2A)
None
 0.68A 4xv2A-3q5iA:
21.7		 4xv2A-3q5iA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 ALA A  84
LYS A  86
LEU A 119
THR A 144
ASP A 211
PHE A 212
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
MG  A 529 (-2.2A)
None
 0.71A 4xv2B-3q5iA:
21.8		 4xv2B-3q5iA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 9 LEU A  63
VAL A  71
ALA A  84
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.82A 5aaaA-3q5iA:
21.8		 5aaaA-3q5iA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 10 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.94A 5aabA-3q5iA:
21.6		 5aabA-3q5iA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
ILE A 128
THR A 144
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.91A 5bvwA-3q5iA:
19.8		 5bvwA-3q5iA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
THR A 144
GLY A 150
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.91A 5bvwA-3q5iA:
19.8		 5bvwA-3q5iA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
LYS A  86
LEU A 119
THR A 144
PHE A 212
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
 0.70A 5cswA-3q5iA:
21.4		 5cswA-3q5iA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 VAL A  71
ALA A  84
LYS A  86
LEU A 119
THR A 144
PHE A 212
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
 0.71A 5cswB-3q5iA:
21.6		 5cswB-3q5iA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 ALA A  84
LYS A  86
GLU A 115
LEU A 119
THR A 144
LEU A 181
HIS A 188
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
None
 0.82A 5hi2A-3q5iA:
21.7		 5hi2A-3q5iA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 12 VAL A  71
ALA A  84
LYS A  86
THR A 144
ASP A 211
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.6A)
MG  A 529 (-2.2A)
 0.58A 5hieC-3q5iA:
20.6		 5hieC-3q5iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 6 PRO A 265
GLU A 296
ALA A 318
LEU A 175
 None
 1.08A 5igiA-3q5iA:
7.0		 5igiA-3q5iA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		5 / 12 GLY A 253
MET A 256
LEU A 260
ALA A 297
PHE A 285
 None
 1.37A 5kc4E-3q5iA:
undetectable		 5kc4E-3q5iA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 11 LEU A  63
GLY A  64
VAL A  71
ALA A  84
GLU A 151
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.1A)
ANP  A1634 (-4.4A)
 0.42A 5lvnA-3q5iA:
28.1		 5lvnA-3q5iA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 10 LEU A  63
VAL A  71
LYS A  86
GLU A 115
PHE A 146
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.8A)
None
 0.93A 5mo4A-3q5iA:
17.1		 5mo4A-3q5iA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 6 TYR A 437
THR A 377
ASP A 384
GLY A 389
 None
None
CA  A   1 (-3.1A)
None
 0.82A 5mraA-3q5iA:
undetectable
5mraB-3q5iA:
undetectable		 5mraA-3q5iA:
14.72
5mraB-3q5iA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 8 ALA A  84
GLU A 115
LEU A 197
ASP A 211
 ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.52A 5owrA-3q5iA:
22.6		 5owrA-3q5iA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 LEU A  73
ALA A  84
GLU A 115
PHE A 146
GLY A 150
LEU A 197
 None
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
 0.53A 5te0A-3q5iA:
25.1		 5te0A-3q5iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 LEU A  73
ALA A  84
GLU A 115
VAL A 210
PHE A 146
GLY A 150
 None
ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.8A)
None
 1.38A 5te0A-3q5iA:
25.1		 5te0A-3q5iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 8 LEU A 376
VAL A 443
LEU A 383
ILE A 435
 None
 0.89A 5v0vA-3q5iA:
undetectable		 5v0vA-3q5iA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 LEU A  63
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.76A 5vcvA-3q5iA:
24.1		 5vcvA-3q5iA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
LEU A 142
THR A 144
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
 0.76A 5vcyA-3q5iA:
23.9		 5vcyA-3q5iA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 ARG A  61
LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
GLY A 150
LEU A 197
 None
ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
 0.92A 5y7zA-3q5iA:
23.6		 5y7zA-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 ARG A  61
LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
GLY A 150
LEU A 197
 None
ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
 0.92A 5y7zA-3q5iA:
23.6		 5y7zA-3q5iA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
GLY A 150
GLU A 154
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.4A)
 1.03A 5y7zA-3q5iA:
23.6		 5y7zA-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
GLY A 150
GLU A 154
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.4A)
 1.03A 5y7zA-3q5iA:
23.6		 5y7zA-3q5iA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
ALA A  84
LYS A  86
GLU A 115
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.92A 5y7zB-3q5iA:
20.1		 5y7zB-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.69A 5y80A-3q5iA:
22.7		 5y80A-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		8 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.77A 5y80A-3q5iA:
22.7		 5y80A-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 8 LEU A  63
VAL A  71
LYS A  86
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
MG  A 529 (-2.2A)
 0.63A 5y9mA-3q5iA:
24.6		 5y9mA-3q5iA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 LEU A  63
GLY A  64
VAL A  71
ALA A  84
LYS A  86
LEU A 142
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
 0.58A 5yu9A-3q5iA:
21.7		 5yu9A-3q5iA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 7 VAL A  71
LYS A  86
ILE A 128
ASP A 211
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
None
MG  A 529 (-2.2A)
 0.59A 5ywmX-3q5iA:
24.8		 5ywmX-3q5iA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		6 / 12 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
 0.63A 5zv2B-3q5iA:
19.8		 5zv2B-3q5iA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		3 / 3 TYR A 180
ASP A 388
GLN A 390
 None
CA  A   1 (-2.8A)
None
 0.95A 6g1pA-3q5iA:
undetectable		 6g1pA-3q5iA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		7 / 12 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
ANP  A1634 (-4.4A)
 0.84A 6hd6B-3q5iA:
19.8		 6hd6B-3q5iA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3q5i PROTEIN KINASE
(Plasmodium
berghei) 		4 / 6 ARG A  47
PHE A 131
LEU A 462
PHE A 463
 None
 1.33A 6nmpC-3q5iA:
2.5
6nmpJ-3q5iA:
undetectable		 6nmpC-3q5iA:
17.23
6nmpJ-3q5iA:
9.16