SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3q60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3q60 ROP5B
(Toxoplasma
gondii) 		4 / 5 LEU A 373
LEU A 369
SER A 341
LEU A 185
 None
 1.03A 1a4lC-3q60A:
undetectable		 1a4lC-3q60A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.69A 1fm9A-3q60A:
undetectable		 1fm9A-3q60A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.68A 1k74A-3q60A:
undetectable		 1k74A-3q60A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3q60 ROP5B
(Toxoplasma
gondii) 		3 / 3 ARG A 430
GLY A 483
ASP A 485
 None
 0.53A 1kf6A-3q60A:
undetectable
1kf6B-3q60A:
undetectable		 1kf6A-3q60A:
19.41
1kf6B-3q60A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.68A 1xlsA-3q60A:
undetectable		 1xlsA-3q60A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.68A 1xlsB-3q60A:
undetectable		 1xlsB-3q60A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.68A 1xlsC-3q60A:
undetectable		 1xlsC-3q60A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.69A 1xlsD-3q60A:
undetectable		 1xlsD-3q60A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.67A 2aclG-3q60A:
undetectable		 2aclG-3q60A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3q60 ROP5B
(Toxoplasma
gondii) 		4 / 8 PHE A 265
PHE A 249
GLY A 243
MET A 206
 MLI  A 601 (-4.8A)
None
ATP  A 600 (-3.3A)
None
 0.90A 2qwxA-3q60A:
undetectable
2qwxB-3q60A:
undetectable		 2qwxA-3q60A:
20.59
2qwxB-3q60A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3q60 ROP5B
(Toxoplasma
gondii) 		4 / 8 PHE A 265
PHE A 249
GLY A 243
MET A 206
 MLI  A 601 (-4.8A)
None
ATP  A 600 (-3.3A)
None
 0.90A 2qx4A-3q60A:
undetectable
2qx4B-3q60A:
undetectable		 2qx4A-3q60A:
20.43
2qx4B-3q60A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 453
GLY A 450
TYR A 454
GLY A 504
PHE A 489
 None
 1.12A 2y7kC-3q60A:
undetectable		 2y7kC-3q60A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 453
GLY A 450
TYR A 454
GLY A 504
PHE A 489
 None
 1.23A 2y7kD-3q60A:
undetectable		 2y7kD-3q60A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 10 ILE A 453
GLY A 450
TYR A 454
GLY A 504
PHE A 489
 None
 1.07A 2y7pA-3q60A:
undetectable		 2y7pA-3q60A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 9 ILE A 453
GLY A 450
TYR A 454
GLY A 504
PHE A 489
 None
 1.23A 2y7wA-3q60A:
undetectable		 2y7wA-3q60A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 LEU A 376
GLN A 448
LEU A 411
GLY A 388
HIS A 389
 None
 1.29A 3g1uB-3q60A:
undetectable		 3g1uB-3q60A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3q60 ROP5B
(Toxoplasma
gondii) 		3 / 3 LEU A 461
PRO A 462
LEU A 465
 None
 0.52A 3hcrA-3q60A:
undetectable		 3hcrA-3q60A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3q60 ROP5B
(Toxoplasma
gondii) 		3 / 3 ALA A 378
ARG A 302
LYS A 302
 None
 0.95A 3kp5B-3q60A:
undetectable		 3kp5B-3q60A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
 0.61A 3og7A-3q60A:
18.6		 3og7A-3q60A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 3q60 ROP5B
(Toxoplasma
gondii) 		4 / 4 TRP A 215
LEU A 334
LEU A 321
THR A 213
 None
 1.39A 4bboD-3q60A:
undetectable		 4bboD-3q60A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.74A 4k6iA-3q60A:
undetectable		 4k6iA-3q60A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 9 PRO A 306
LEU A 335
VAL A 248
LEU A 279
TYR A 333
 MLI  A 601 ( 4.5A)
MLI  A 601 (-4.7A)
ATP  A 600 (-4.3A)
None
None
 1.50A 4puoA-3q60A:
0.0		 4puoA-3q60A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3q60 ROP5B
(Toxoplasma
gondii) 		4 / 8 PHE A 265
PHE A 249
GLY A 243
MET A 206
 MLI  A 601 (-4.8A)
None
ATP  A 600 (-3.3A)
None
 0.92A 4qogA-3q60A:
undetectable
4qogB-3q60A:
undetectable		 4qogA-3q60A:
20.59
4qogB-3q60A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ARG A 480
ALA A 435
LEU A 444
GLY A 388
GLN A 448
 None
 0.99A 4r3aB-3q60A:
undetectable		 4r3aB-3q60A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q60 ROP5B
(Toxoplasma
gondii) 		6 / 12 ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
ASP A 407
 ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
MG  A 602 ( 2.5A)
 1.39A 4xv2A-3q60A:
18.2		 4xv2A-3q60A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q60 ROP5B
(Toxoplasma
gondii) 		6 / 12 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
 0.90A 4xv2A-3q60A:
18.2		 4xv2A-3q60A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ALA A 261
LEU A 304
PHE A 396
GLY A 406
ASP A 407
 ATP  A 600 (-3.6A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
MG  A 602 ( 2.5A)
 0.96A 4xv2B-3q60A:
18.2		 4xv2B-3q60A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q60 ROP5B
(Toxoplasma
gondii) 		6 / 12 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
 0.87A 5cswA-3q60A:
18.2		 5cswA-3q60A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q60 ROP5B
(Toxoplasma
gondii) 		6 / 12 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
 0.89A 5cswB-3q60A:
18.2		 5cswB-3q60A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 LEU A 451
GLY A 450
GLU A 431
TYR A 427
LEU A 465
 None
 1.35A 5czyA-3q60A:
undetectable		 5czyA-3q60A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q60 ROP5B
(Toxoplasma
gondii) 		6 / 12 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
 0.87A 5hieA-3q60A:
7.4		 5hieA-3q60A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q60 ROP5B
(Toxoplasma
gondii) 		6 / 12 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
 0.87A 5hieB-3q60A:
7.3		 5hieB-3q60A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q60 ROP5B
(Toxoplasma
gondii) 		6 / 12 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
GLY A 406
 ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
None
 0.87A 5hieD-3q60A:
17.6		 5hieD-3q60A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 10 LEU A 236
PHE A 249
PRO A 216
ALA A 212
VAL A 264
 None
 1.33A 5m0oA-3q60A:
undetectable		 5m0oA-3q60A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3q60 ROP5B
(Toxoplasma
gondii) 		4 / 8 LEU A 515
ARG A 505
LEU A 449
ILE A 503
 None
 0.97A 5v0vA-3q60A:
1.2		 5v0vA-3q60A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3q60 ROP5B
(Toxoplasma
gondii) 		6 / 12 LEU A 240
ALA A 261
LYS A 263
LEU A 335
PHE A 396
GLY A 406
 None
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
MLI  A 601 (-4.7A)
ATP  A 600 (-4.4A)
None
 0.92A 5vcvA-3q60A:
19.0		 5vcvA-3q60A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3q60 ROP5B
(Toxoplasma
gondii) 		4 / 8 GLY A 504
ASN A 508
ALA A 446
PHE A 506
 None
 0.84A 5xu8A-3q60A:
undetectable		 5xu8A-3q60A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3q60 ROP5B
(Toxoplasma
gondii) 		5 / 12 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.79A 5z12B-3q60A:
undetectable		 5z12B-3q60A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3q60 ROP5B
(Toxoplasma
gondii) 		3 / 3 LYS A 263
LEU A 304
ASP A 407
 MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
MG  A 602 ( 2.5A)
 0.84A 5zv2A-3q60A:
18.9		 5zv2A-3q60A:
12.43